- Efficient topical delivery of plasmid DNA to lung in vivo mediated by putative triggered, PEGylated pDNA nanoparticles
[作者：Aissaoui, A; Chami, M; Hussein, M; Miller, AD,期刊：Journal of controlled release, 页码：275-284 , 文章类型： Article，,卷期：2011年154-3]
- Non-viral vectors are considered safer than viral vectors and show clinical potential, but remain less efficient in terms of DNA delivery. Here we report how cationic liposomes, prepared from new cationic lipid, N',N',-d...
- Development of an adenovirus vector lacking the expression of virus-associated RNAs
[作者：Machitani, M; Katayama, K; Sakurai, F; Matsui, H; Yamaguchi, T; Suzuki, T; Miyoshi, H; Kawabata, K; Mizuguchi, H,期刊：Journal of controlled release, 页码：285-289 , 文章类型： Article，,卷期：2011年154-3]
- A major limitation of the use of adenovirus (Ad) vectors is the innate immune response, which causes inflammatory cytokine production and tissue damages. To overcome this limitation, it is necessary to develop safer Ad v...
- Immunophilin-loaded erythrocytes as a new delivery strategy for immunosuppressive drugs
[作者：Biagiotti, S; Rossi, L; Bianchi, M; Giacomini, E; Pierige, F; Serafini, G; Conaldi, PG; Magnani, M,期刊：Journal of controlled release, 页码：306-313 , 文章类型： Article，,卷期：2011年154-3]
- Cyclosporine A (CsA) and tacrolimus (also known as FK506) are natural compounds with immunosuppressive activity that have improved the outcome of organ transplantation. Unfortunately, both drugs are characterised by high...
- In situ dose amplification by apoptosis-targeted drug delivery
[作者：Wang, K; Na, MH; Hoffman, AS; Shim, G; Han, SE; Oh, YK; Kwon, IC; Kim, IS; Lee, BH,期刊：Journal of controlled release, 页码：214-217 , 文章类型： Article，,卷期：2011年154-3]
- When tumor cells undergo apoptosis in response to chemotherapy, the levels of apoptotic biomarkers such as histone H1 are increased at the tumor. This would amplify in situ homing signals and thus drug delivery by apopto...
- How to screen non-viral gene delivery systems in vitro?
[作者：van Gaal, EVB; van Eijk, R; Oosting, RS; Kok, RJ; Hennink, WE; Crommelin, DJA; Mastrobattista, E,期刊：Journal of controlled release, 页码：218-232 , 文章类型： Review，,卷期：2011年154-3]
- Screening of new gene delivery candidates regarding transfection efficiency and toxicity is usually performed by reading out transgene expression levels relative to a reference formulation after in vitro transfection. Ho...
- PEGylation improves pharmacokinetic profile, liver uptake and efficacy of Interferon gamma in liver fibrosis
[作者：Bansal, R; Post, E; Proost, JH; de Jager-Krikken, A; Poelstra, K; Prakash, J,期刊：Journal of controlled release, 页码：233-240 , 文章类型： Article，,卷期：2011年154-3]
- Interferon gamma (IFN gamma) is a potent cytokine that displays a variety of anti-viral, anti-proliferative, immunomodulatory, apoptotic and anti-fibrotic functions. However, its clinical use is limited to the treatment ...
- Biodegradable star HPMA polymer-drug conjugates: Biodegradability, distribution and anti-tumor efficacy
[作者：Etrych, T; Kovar, L; Strohalm, J; Chytil, P; Rihova, B; Ulbrich, K,期刊：Journal of controlled release, 页码：241-248 , 文章类型： Article，,卷期：2011年154-3]
- Herein, new biodegradable star polymer-doxorubicin conjugates designed for passive tumor targeting were investigated, and their synthesis, physico-chemical characterization, drug release, biodegradation, biodistribution ...
- The efficacy of intracranial PLG-based vaccines is dependent on direct implantation into brain tissue
[作者：Ali, OA; Doherty, E; Bell, WJ; Fradet, T; Hudak, J; Laliberte, MT; Mooney, DJ; Emerich, DF,期刊：Journal of controlled release, 页码：249-257 , 文章类型： Article，,卷期：2011年154-3]
- We previously engineered a macroporous, polymer-based vaccine that initially produces GM-CSF gradients to recruit local dendritic cells and subsequently presents CpG oligonucleotides, and tumor lysate to cell infiltrates...
- Affinity-based growth factor delivery using biodegradable, photocrosslinked heparin-alginate hydrogels
[作者：Jeon, O; Powell, C; Solorio, LD; Krebs, MD; Alsberg, E,期刊：Journal of controlled release, 页码：258-266 , 文章类型： Article，,卷期：2011年154-3]
- Photocrosslinkable biomaterials are promising for tissue engineering applications due to their capacity to be injected and form hydrogels in situ in a minimally invasive manner. Our group recently reported on the develop...
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