- Cell surface glycoproteomic analysis of prostate cancer-derived PC-3 cells
[作者:Hubbard, SC; Boyce, M; McVaugh, CT; Peehl, DM; Bertozzi, CR,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:4945-4950 , 文章类型: Article,,卷期:2011年21-17]
- Most clinically approved biomarkers of cancer are glycoproteins, and those residing on the cell surface are of particular interest in biotherapeutics. We report a method for selective labeling, affinity enrichment, and i...
- The Mycobacterium tuberculosis CysQ phosphatase modulates the biosynthesis of sulfated glycolipids and bacterial growth
[作者:Hatzios, SK; Schelle, MW; Newton, GL; Sogi, KM; Holsclaw, CM; Fahey, RC; Bertozzi, CR,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:4956-4959 , 文章类型: Article,,卷期:2011年21-17]
- CysQ is a 3'-phosphoadenosine-5'-phosphatase that dephosphorylates intermediates from the sulfate assimilation pathway of Mycobacterium tuberculosis (Mtb). Here, we demonstrate that cysQ disruption attenuates Mtb growth ...
- Profiling base excision repair glycosylases with synthesized transition state analogs
[作者:Chu, AM; Fettinger, JC; David, SS,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:4969-4972 , 文章类型: Article,,卷期:2011年21-17]
- Two base excision repair glycosylase (BER) transition state (TS) mimics, (3R,4R)-1-benzyl (hydroxymethyl) pyrrolidin-3-ol (1NBn) and (3R,4R)-(hydroxymethyl) pyrrolidin-3-ol (1N), were synthesized using an improved method...
- Deciphering glycan linkages involved in Jurkat cell interactions with gold-coated nanofibers via sugar-displayed thiols
[作者:Du, J; Che, PL; Aich, U; Tan, E; Kim, HJ; Sampathkumar, SG; Yarema, KJ,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:4980-4984 , 文章类型: Article,,卷期:2011年21-17]
- Metabolic oligosaccharide engineering (MOE) provides a method to install novel chemical functional groups into the glycocalyx of living cells. In this Letter we use this technology to compare the impact of replacing natu...
- Metabolic labeling of fucosylated glycoproteins in Bacteroidales species
[作者:Besanceney-Webler, C; Jiang, H; Wang, W; Baughn, AD; Wu, P,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:4989-4992 , 文章类型: Article,,卷期:2011年21-17]
- Members of the Bacteroidales order are among the most abundant gram-negative bacteria of the human colonic microbiota. These species decorate their cell-surface glycoproteins with fucosylated glycans, which are believed ...
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