- Cancer and Virus Leads by HTS, Chemical Design and SEA Data Mining
[作者：Thepchatri, P; Min, J; Ganesh, T; Du, YH; Lewis, I; Kurtkaya, S; Prussia, A; Li, LA; Sneed, B; Plemper, RK; Fu, HA; Liotta, DC; Snyder, JP; Dingledine, R; Sun, AM,期刊：Current Topics in Medicinal Chemistry, 页码：1159-1171 , 文章类型： Review，,卷期：2009年9-13]
- A variety of medicinal chemistry approaches can be used for the identification of hits, generation of leads and to accelerate the development of drug candidates. The Emory Chemical and Biology Discovery Center (ECBDC) ha...
- Small-Molecule Modulators of the NF-kappa B Pathway Newly Identified by a Translocation-Based Cellular Assay
[作者：Xie, YL; Rinderspacher, A; Liu, YD; Gong, GL; Smith, DH; Wyler, M; Branden, L; Deng, SX,期刊：Current Topics in Medicinal Chemistry, 页码：1172-1180 , 文章类型： Review，,卷期：2009年9-13]
- Nuclear factor kappa B (NF-kappa B) is an important transcription factor. Aberrant regulation of the NF-kappa B pathway is frequently observed in a number of major ailments such as cancer and inflammatory diseases. Hence...
- The Pilot Phase of the NIH Chemical Genomics Center
[作者：Thomas, CJ; Auld, DS; Huang, RL; Huang, WW; Jadhav, A; Johnson, RL; Leister, W; Maloney, DJ; Marugan, JJ; Michael, S; Simeonov, A; Southall, N; Xia, MH; Zheng, W; Inglese, J; Austin, CP,期刊：Current Topics in Medicinal Chemistry, 页码：1181-1193 , 文章类型： Review，,卷期：2009年9-13]
- The NIH Chemical Genomics Center (NCGC) was the inaugural center of the Molecular Libraries and Screening Center Network (MLSCN). Along with the nine other research centers of the MLSCN, the NCGC was established with a p...
- A Case Study from the Chemistry Core of the Pittsburgh Molecular Library Screening Center: The Polo-like Kinase Polo-Box Domain (Plk1-PBD)
[作者：Wipf, P; Arnold, D; Carter, K; Dong, SZ; Johnston, PA; Sharlow, E; Lazo, JS; Huryn, DH,期刊：Current Topics in Medicinal Chemistry, 页码：1194-1205 , 文章类型： Review，,卷期：2009年9-13]
- The Polo-like kinase (Plk) family comprises four cell cycle serine/threonine kinases, Plk1-4. Among these, Plk1 has been most thoroughly characterized; it contains a conserved kinase domain and a C-terminal docking site ...
- Discovery and Development of a Potent and Highly Selective Small Molecule Muscarinic Acetylcholine Receptor Subtype I (mAChR 1 or M-1) Antagonist In Vitro and In Vivo Probe
[作者：Weaver, CD; Sheffler, DJ; Lewis, LM; Bridges, TM; Williams, R; Nalywajko, NT; Kennedy, JP; Mulder, MM; Jadhav, S; Aldrich, LA; Jones, CK; Marlo, J; Niswender, CM; Mock, MM; Zheng, F; Conn, PJ; Lindsley, CW,期刊：Current Topics in Medicinal Chemistry, 页码：1217-1226 , 文章类型： Review，,卷期：2009年9-13]
- This article describes the discovery and development of the first highly selective, small molecule antagonist of the muscarinic acetylcholine receptor subtype I (mAChR1 or M-1). An M-1 functional, cell-based, calcium-mob...
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