个性化文献订阅>文章检索

文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共7条记录   Untitled [作者：Reitz, AB,期刊：Current Topics in Medicinal Chemistry, 页码：964-964 , 文章类型： Editorial Material，,卷期：2009年9-11] ADME Optimization and Toxicity Assessment in Early- and Late-Phase Drug Discovery [作者：Caldwell, GW; Yan, ZY; Tang, WM; Dasgupta, M; Hasting, B,期刊：Current Topics in Medicinal Chemistry, 页码：965-980 , 文章类型： Review，,卷期：2009年9-11] Integrating physicochemical, drug metabolism, pharmacokinetics, ADME, and toxicity assays into drug discovery in order to reduce the attrition rates in clinical development is reviewed. The review is organized around thr... Quinolones: Action and Resistance Updated [作者：Drlica, K; Hiasa, H; Kerns, R; Malik, M; Mustaev, A; Zhao, XL,期刊：Current Topics in Medicinal Chemistry, 页码：981-998 , 文章类型： Review，,卷期：2009年9-11] The quinolones trap DNA gyrase and DNA topoisomerase IV on DNA as complexes in which the DNA is broken but constrained by protein. Early studies suggested that drug binding occurs largely along helix-4 of the GyrA (gyras... Endogenous Opioids and Addiction to Alcohol and other Drugs of Abuse [作者：Gianoulakis, C,期刊：Current Topics in Medicinal Chemistry, 页码：999-1015 , 文章类型： Review，,卷期：2009年9-11] There is significant experimental evidence implicating the endogenous opioid system (opioid peptides and opioid receptors) with the processes of reward and reinforcement Indeed, many behaviors associated with reward and ... HIV-1 IN Inhibitors: 2010 Update and Perspectives [作者：Marchand, C; Maddali, K; Metifiot, M; Pommier, Y,期刊：Current Topics in Medicinal Chemistry, 页码：1016-1037 , 文章类型： Review，,卷期：2009年9-11] Integrase (IN) is the newest validated target against AIDS and retroviral infections. The remarkable activity of raltegravir (Isentress (R)) led to its rapid approval by the FDA in 2007 as the first IN inhibitor. Several... The p38 alpha Kinase Plays a Central Role In Inflammation [作者：Schieven, GL,期刊：Current Topics in Medicinal Chemistry, 页码：1038-1048 , 文章类型： Review，,卷期：2009年9-11] The p38 kinase plays a central role in inflammation, and it has been the subject of extensive efforts in both basic research and drug discovery. This review summarizes the biology of the p38 kinase with a focus on its ro... Sugar Sulfamates for Seizure Control: Discovery and Development of Topiramate, a Structurally Unique Antiepileptic Drug [作者：Maryanoff, BE,期刊：Current Topics in Medicinal Chemistry, 页码：1049-1062 , 文章类型： Review，,卷期：2009年9-11] TOPAMAX (R) (topiramate) 1, is a broad-spectrum anticonvulsant that has been marketed worldwide for the treatment of epilepsy and migraine. We discovered this blockbuster drug serendipitously in a project that originally...