- The Role of Autophagy on the Survival of Dopamine Neurons
[作者：Isidoro, C; Biagioni, F; Giorgi, FS; Fulceri, F; Paparelli, A; Fornai, F,期刊：Current Topics in Medicinal Chemistry, 页码：869-879 , 文章类型： Review，,卷期：2009年9-10]
- Autophagy is the mechanism through which cells degrade oxidized membranes-organelles and mis/unfolded proteins, in this latter function cooperating with the ubiquitin-proteasome system ( UP system). Although autophagy ha...
- Half a Century of l-DOPA
[作者：Mena, MA; Casarejos, MJ; Solano, RM; de Yebenes, JG,期刊：Current Topics in Medicinal Chemistry, 页码：880-893 , 文章类型： Review，,卷期：2009年9-10]
- L-DOPA is a di-hydroxy-phenyl, catecholamine precursor, amino acid, initially considered as an inert compound and now the key stone for the treatment of Parkinson's disease (PD) and some hereditary dystonias. L-DOPA, whe...
- Behavioural Sensitisation During Dopamine Replacement Therapy in Parkinson's Disease is Reminiscent of the Addicted Brain
[作者：Biagioni, F; Pellegrini, A; Ruggieri, S; Murri, L; Paparelli, A; Fornai, F,期刊：Current Topics in Medicinal Chemistry, 页码：894-902 , 文章类型： Review，,卷期：2009年9-10]
- The intermittent oral intake of the dopamine (DA) precursor L-3,4-dihydroxyphenylalanine (L-DOPA) is the classic therapy of Parkinson's disease (PD). In this way, the drug precursor can be metabolised into the active neu...
- Cognitive Impairment and Dementia in Patients with Parkinson Disease
[作者：Leverenz, JB; Quinn, JF; Zabetian, C; Zhang, J; Montine, KS; Montine, TJ,期刊：Current Topics in Medicinal Chemistry, 页码：903-912 , 文章类型： Review，,卷期：2009年9-10]
- Parkinson disease (PD) is an already prevalent neurodegenerative disease that is poised to at least double over the next 25 years. Although best known for its characteristic movement disorder, PD is now appreciated commo...
- Recent Progress in the Development of mGluR4 Positive Allosteric Modulators for the Treatment of Parkinson's Disease
[作者：Lindsley, CW; Niswender, CM; Engers, DW; Hopkins, CR,期刊：Current Topics in Medicinal Chemistry, 页码：949-963 , 文章类型： Review，,卷期：2009年9-10]
- This article describes recent advances in the development and biological evaluation of small molecule mGluR4 positive allosteric modulators (PAMs), and, to a lesser extent, orthosteric agonists. Due to its expression in ...
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