Current Topics in Medicinal Chemistry————————个性化文献订阅—

Pharmacological Targeting of the Hsp70 Chaperone
[作者：Patury, S; Miyata, Y; Gestwicki, JE,期刊：Current Topics in Medicinal Chemistry, 页码：1337-1351 , 文章类型： Review，,卷期：2009年9-15]
The molecular chaperone, heat shock protein 70 (Hsp70), acts at multiple steps in a protein's life cycle, including during the processes of folding, trafficking, remodeling and degradation. To accomplish these various ta...

Strategies for Stalling Malignancy: Targeting Cancer's Addiction to Hsp90
[作者：Prodromou, C,期刊：Current Topics in Medicinal Chemistry, 页码：1352-1368 , 文章类型： Review，,卷期：2009年9-15]
Hsp90 is involved in the maturation and activation of client proteins. Often these are key proteins involved in signal transduction and regulatory pathways that in a mutated and/or deregulated form sustain an oncogenic c...

Structural and Computational Biology of the Molecular Chaperone Hsp90: From Understanding Molecular Mechanisms to Computer-Based Inhibitor Design
[作者：Verkhivker, GM; Dixit, A; Morra, G; Colombo, G,期刊：Current Topics in Medicinal Chemistry, 页码：1369-1385 , 文章类型： Review，,卷期：2009年9-15]
The molecular chaperone Hsp90 (90 kDa heat-shock protein) mediates many fundamental cellular pathways involved in cell proliferation, cell survival, and cellular stress response. Hsp90 is responsible for the correct conf...

Ansamycin Inhibitors of Hsp90: Nature's Prototype for Anti-Chaperone Therapy
[作者：Porter, JR; Ge, JE; Lee, J; Normant, E; West, K,期刊：Current Topics in Medicinal Chemistry, 页码：1386-1418 , 文章类型： Review，,卷期：2009年9-15]
The ansamycin class of natural products is well known for its anti-tumor effects and has been extensively studied by cancer researchers for nearly four decades. The first description of geldanamycin in the scientific lit...

Hsp90 Inhibition with Resorcylic Acid Lactones (RALs)
[作者：Winssinger, N; Fontaine, JG; Barluenga, S,期刊：Current Topics in Medicinal Chemistry, 页码：1419-1435 , 文章类型： Review，,卷期：2009年9-15]
Heat shock protein 90 (Hsp90) is an ATP-dependent chaperone which is involved in the post-translational maturation and stabilization of over one hundred proteins ("its clients"). In the absence of Hsp90's chaperoning, it...

Purine-Scaffold Hsp90 Inhibitors
[作者：Taldone, T; Chiosis, G,期刊：Current Topics in Medicinal Chemistry, 页码：1436-1446 , 文章类型： Review，,卷期：2009年9-15]
Hsp90 is a molecular chaperone with important roles in regulating the function of several proteins with potential pathogenic activity. Because many of these proteins are involved in cancer and neurodegenerative promoting...

Alternate Strategies of Hsp90 Modulation for the Treatment of Cancer and Other Diseases
[作者：Brandt, GEL; Blagg, BSJ,期刊：Current Topics in Medicinal Chemistry, 页码：1447-1461 , 文章类型： Review，,卷期：2009年9-15]
The 90 kDa heat shock protein (Hsp90) has become a validated target for the development of anti-cancer agents. Several Hsp90 inhibitors are currently under clinical trial investigation for the treatment of cancer. All of...

Assays for Identification of Hsp90 Inhibitors and Biochemical Methods for Discriminating their Mechanism of Action
[作者：Matts, RL; Manjarrez, JR,期刊：Current Topics in Medicinal Chemistry, 页码：1462-1478 , 文章类型： Review，,卷期：2009年9-15]
The Hsp90-dependence of many oncogenic proteins has precipitated a great deal of interest in Hsp90 as a drug target, as evidence mounts that Hsp90 inhibitors may be effective chemotherapeutic agents for the treatment of ...

Update on Hsp90 Inhibitors in Clinical Trial
[作者：Kim, YS; Alarcon, SV; Lee, S; Lee, MJ; Giaccone, G; Neckers, L; Trepel, JB,期刊：Current Topics in Medicinal Chemistry, 页码：1479-1492 , 文章类型： Review，,卷期：2009年9-15]
Twenty-five years ago the first small molecule inhibitors of Hsp90 were identified. In the intervening years there has been dramatic progress in basic scientific understanding of the Hsp90 chaperone machinery and in the ...