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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共8条记录   Methods and Non-Cancer Applications of HDAC Inhibition [作者：Wiest, O,期刊：Current Topics in Medicinal Chemistry, 页码：226-226 , 文章类型： Editorial Material，,卷期：2009年9-3] Assays for Histone Deacetylases [作者：Hauser, AT; Jung, M; Jung, M,期刊：Current Topics in Medicinal Chemistry, 页码：227-234 , 文章类型： Review，,卷期：2009年9-3] Epigenetics is defined as heritable changes in gene expresssion, i. e. the presentation of a certain phenotype, without alterations to the genetic code. This is a central phenomenon in developmental biology but also for ... Novel Structural Insights into Class I and II Histone Deacetylases [作者：Ficner, R,期刊：Current Topics in Medicinal Chemistry, 页码：235-240 , 文章类型： Review，,卷期：2009年9-3] The deacetylation of modified lysine residues of histones and other proteins is catalyzed by histone deacetlyases (HDACs). HDACs play an important role in the regulation of many biological processes such as cell-cycle, c... Computational Studies on the Histone Deacetylases and the Design of Selective Histone Deacetylase Inhibitors [作者：Wang, DF,期刊：Current Topics in Medicinal Chemistry, 页码：241-256 , 文章类型： Review，,卷期：2009年9-3] The catalytic activity of the histone deacetylase ( HDAC) enzymes is directly relevant to the pathogenesis of cancer as well as several other diseases. HDAC inhibitors have been shown to have the potential to treat sever... Inhibition of Histone Deacetylases: A Pharmacological Approach to the Treatment of Non-Cancer Disorders [作者：Wiech, NL; Fisher, JF; Helquist, P; Wiest, O,期刊：Current Topics in Medicinal Chemistry, 页码：257-271 , 文章类型： Review，,卷期：2009年9-3] The dynamics of gene expression are regulated by histone acetylases (HATs) and histone deacetylases (HDACs) that control the acetylation state of lysine side chains of the histone proteins of chromatin. The catalytic act... Non-Cancer Uses of Histone Deacetylase Inhibitors: Effects on Infectious Diseases and beta-Hemoglobinopathies [作者：Rotili, D; Simonetti, G; Savarino, A; Palamara, AT; Migliaccio, AR; Mai, A,期刊：Current Topics in Medicinal Chemistry, 页码：272-291 , 文章类型： Review，,卷期：2009年9-3] After the approval of suberoylanilide hydroxamic acid (SAHA, vorinostat, Zolinza (R)) for the treatment of cutaneous T cell lymphoma (CTCL), a number of HDAC inhibitors (HDACi) are currently in Phase II or III clinical t... Targeting Histone Deacetylase Inhibitors for Anti-Malarial Therapy [作者：Andrews, KT; Tran, TN; Wheatley, NC; Fairlie, DP,期刊：Current Topics in Medicinal Chemistry, 页码：292-308 , 文章类型： Review，,卷期：2009年9-3] It is now clear that histone acetylation plays key roles in regulating gene transcription in both eukaryotes and prokaryotes, the acetylated form inducing gene expression while deacetylation silences genes. Recent studie... Histone Deacetylase Inhibitors In Inflammatory Disease [作者：Halili, MA; Andrews, MR; Sweet, MJ; Fairlie, DP,期刊：Current Topics in Medicinal Chemistry, 页码：309-319 , 文章类型： Review，,卷期：2009年9-3] Lysine acetylation is becoming increasingly appreciated as a key post-translational modification in the endogenous regulation of protein function. The so-called histone acetyl transferases (HATs) and histone deacetylases...