- Amoxapine Inhibits the Delayed Rectifier Outward K+ Current in Mouse Cortical Neurons via cAMP/Protein Kinase A Pathways
[作者:He, YL; Zhan, XQ; Yang, G; Sun, J; Mei, YA,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:437-445 , 文章类型: Article,,卷期:2010年332-2]
- Ion channels are known to be modulated by antidepressant drugs, but the molecular mechanisms are not known. We have shown that the antidepressant drug amoxapine suppresses rectifier outward K+ (I-K) currents in mouse cor...
- Liposome-Encapsulated Hemoglobin Ameliorates Ischemic Stroke in Nonhuman Primates: An Acute Study
[作者:Kawaguchi, AT; Haida, M; Yamano, M; Fukumoto, D; Ogata, Y; Tsukada, H,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:429-436 , 文章类型: Article,,卷期:2010年332-2]
- An artificial oxygen carrier, liposome-encapsulated hemoglobin (LEH), protective in a rodent stroke model, was quantitatively evaluated in monkeys. Serial positron emission tomography studies using the steady-state O-15-...
- Impaired Vasoconstriction and Nitric Oxide-Mediated Relaxation in Pulmonary Arteries of Hypoxia- and Monocrotaline-Induced Pulmonary Hypertensive Rats
[作者:Mam, V; Tanbe, AF; Vitali, SH; Arons, E; Christou, HA; Khalil, RA,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:455-462 , 文章类型: Article,,卷期:2010年332-2]
- Pulmonary hypertension (PH) is a life-threatening disease with unclear vascular mechanisms. We tested whether PH involves abnormal pulmonary vasoconstriction and impaired vasodilation. Male Sprague-Dawley rats were expos...
- Differential Pharmacodynamic Effects of Paclitaxel Formulations in an Intracranial Rat Brain Tumor Model
[作者:Zhou, R; Mazurchuk, RV; Tamburlin, JH; Harrold, JM; Mager, DE; Straubinger, RM,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:479-488 , 文章类型: Article,,卷期:2010年332-2]
- Nano- and microparticulate carriers can exert a beneficial impact on the pharmacodynamics of anticancer agents. To investigate the relationships between carrier and antitumor pharmacodynamics, paclitaxel incorporated in ...
- Identification and Analysis of Two Splice Variants of Human G2A Generated by Alternative Splicing
[作者:Ogawa, A; Obinata, H; Hattori, T; Kishi, M; Tatei, K; Ishikawa, O; Izumi, T,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:469-478 , 文章类型: Article,,卷期:2010年332-2]
- G2A is a G protein-coupled receptor that can be induced by various stressors. G2A is reported to have proton-sensing activity that mediates intracellular inositol phosphate (IP) accumulation with decreasing pH. We previo...
- The Aminoglycosides Modulate the Acid-Sensing Ionic Channel Currents in Dorsal Root Ganglion Neurons from the Rat
[作者:Garza, A; Lopez-Ramirez, O; Vega, R; Soto, E,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:489-499 , 文章类型: Article,,卷期:2010年332-2]
- Acid-sensing ionic channels (ASICs) have been shown to have a significant role in a growing number of physiological and pathological processes, such as nociception, synaptic transmission and plasticity, mechanosensation,...
- Dysopsonin Activity of Serum DNA-Binding Proteins Favorable for Gene Delivery
[作者:Liu, F; Frick, A; Yuan, X; Huang, L,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:500-504 , 文章类型: Article,,卷期:2010年332-2]
- Naked DNA is regarded as the safest and simplest method of gene delivery. However, normally intravenously injected naked plasmid DNA is rapidly eliminated from the blood. It has been hypothesized that opsonins, a categor...
- Imipramine, in Part through Tumor Necrosis Factor alpha Inhibition, Prevents Cognitive Decline and beta-Amyloid Accumulation in a Mouse Model of Alzheimer's Disease
[作者:Chavant, F; Deguil, J; Pain, S; Ingrand, I; Milin, S; Fauconneau, B; Perault-Pochat, MC; Lafay-Chebassier, C,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:505-514 , 文章类型: Article,,卷期:2010年332-2]
- Alzheimer's disease (AD), the most common form of dementia in the older people, is a multifactoral pathology, characterized by cognitive deficits, increase in cerebral deposition of the beta-amyloid (A beta) peptide, neu...
- Pharmacologic Antagonism of the Oral Aversive Taste-Directed Response to Capsaicin in a Mouse Brief Access Taste Aversion Assay
[作者:Long, DJ; Devantier, HR; Brennan, FX; Bryant, RW; Salemme, FR; Palmer, RK,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:525-530 , 文章类型: Article,,卷期:2010年332-2]
- Chemosensory signaling by the tongue is a primary determinant of ingestive behavior and is mediated by specific interactions between tastant molecules and G protein-coupled and ion channel receptors. The functional relat...
- Cardamonin Is a Bifunctional Vasodilator that Inhibits Ca(v)1.2 Current and Stimulates K(Ca)1.1 Current in Rat Tail Artery Myocytes
[作者:Fusi, F; Cavalli, M; Mulholland, D; Crouch, N; Coombes, P; Dawson, G; Bova, S; Sgaragli, G; Saponara, S,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:531-540 , 文章类型: Article,,卷期:2010年332-2]
- An in-depth analysis of the effects of cardamonin, 2',4'-dihydroxy-6'-methoxychalcone, on rat tail artery preparations was performed by means of whole-cell patch-clamp recordings of Ca(v)1.2 Ca2+ [I-Ca(L)] or Ba2+ [I-Ba(...
- Lipoxin A(4) Reduces Lipopolysaccharide-Induced Inflammation in Macrophages and Intestinal Epithelial Cells through Inhibition of Nuclear Factor-kappa B Activation
[作者:Kure, I; Nishiumi, S; Nishitani, Y; Tanoue, T; Ishida, T; Mizuno, M; Fujita, T; Kutsumi, H; Arita, M; Azuma, T; Yoshida, M,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:541-548 , 文章类型: Article,,卷期:2010年332-2]
- Lipoxins, which are bioactive lipids derived from omega-6 polyunsaturated fatty acids, play important roles in various biological functions. In this study, the anti-inflammatory effects of lipoxin A(4) (LXA4; 5S, 6R, 15S...
- Intrahypothalamic Injection of the HIV-1 Envelope Glycoprotein Induces Fever via Interaction with the Chemokine System
[作者:Benamar, K; Addou, S; Yondorf, M; Geller, EB; Eisenstein, TK; Adler, MW,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:549-553 , 文章类型: Article,,卷期:2010年332-2]
- Wasting syndrome is a common complication of HIV infection and is marked by progressive weight loss and weakness, often associated with fever. The mechanisms involved in the pathogenesis of these syndromes are not well d...
- Endothelium-Dependent Vasodilator Effects of Peroxisome Proliferator-Activated Receptor beta Agonists via the Phosphatidyl-Inositol-3 Kinase-Akt Pathway
[作者:Jimenez, R; Sanchez, M; Zarzuelo, MJ; Romero, M; Quintela, AM; Lopez-Sepulveda, R; Galindo, P; Gomez-Guzman, M; Haro, JM; Zarzuelo, A; Perez-Vizcaino, F; Duarte, J,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:554-561 , 文章类型: Article,,卷期:2010年332-2]
- Peroxisome proliferator-activated receptor beta/delta (PPAR-beta) is a ligand- activated transcription factor belonging to the nuclear hormone receptor superfamily that regulates the transcription of many target genes. M...
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