- Pharmacological Characterization of the Discriminative Stimulus of Inhaled 1,1,1-Trichloroethane
[作者:Shelton, KL,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:612-620 , 文章类型: Article,,卷期:2010年333-2]
- The present study examined the involvement of the GABA A, N-methy-D-aspartate (NMDA), nicotinic acetylcholine, and mu-opioid receptor systems in the transduction of the discriminative stimulus effects of the abused inhal...
- Up-Regulation of the RhoA/Rho-Kinase Signaling Pathway in Corpus Cavernosum from Endothelial Nitric-Oxide Synthase (NOS), but Not Neuronal NOS, Null Mice (vol 333, pg 184, 2010)
[作者:Priviero, FBM; Jin, LM; Ying, Z; Teixeira, CE; Webb, RC,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:629-629 , 文章类型: Correction,,卷期:2010年333-2]
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- Butrin, Isobutrin, and Butein from Medicinal Plant Butea monosperma Selectively Inhibit Nuclear Factor-kappa B in Activated Human Mast Cells: Suppression of Tumor Necrosis Factor-alpha, Interleukin (IL)-6, and IL-8
[作者:Rasheed, Z; Akhtar, N; Khan, A; Khan, KA; Haqqi, TM,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:354-363 , 文章类型: Article,,卷期:2010年333-2]
- Activation of mast cells in rheumatoid synovial tissue has often been associated with tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-8 production and disease pathogenesis by adjacent cell types. Butea mono...
- Enhanced Sensitivity of Pancreatic Cancer Cells to Concurrent Inhibition of Aberrant Signal Transducer and Activator of Transcription 3 and Epidermal Growth Factor Receptor or Src
[作者:Jaganathan, S; Yue, PB; Turkson, J,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:373-381 , 文章类型: Article,,卷期:2010年333-2]
- Many molecular aberrations occur in pancreatic cancer. Although aberrant epidermal growth factor receptor (EGFR), Src, and signal transducer and activator of transcription 3 (Stat3) are implicated in pancreatic cancer, t...
- A Mouse Model of Severe Halothane Hepatitis Based on Human Risk Factors
[作者:Dugan, CM; MacDonald, AE; Roth, RA; Ganey, PE,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:364-372 , 文章类型: Article,,卷期:2010年333-2]
- Halothane (2-bromo-2-chloro-1,1,1-trifluoro-ethane) is an inhaled anesthetic that induces severe, idiosyncratic liver injury, i.e., "halothane hepatitis," in approximately 1 in 20,000 human patients. We used known human ...
- G beta gamma Signaling Promotes Breast Cancer Cell Migration and Invasion
[作者:Kirui, JK; Xie, Y; Wolff, DW; Jiang, HH; Abel, PW; Tu, YP,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:393-403 , 文章类型: Article,,卷期:2010年333-2]
- Signaling through G protein-coupled receptors (GPCRs) promotes breast cancer metastasis. G proteins convey GPCR signals by dissociating into G alpha and G beta gamma subunits. The aim of the present study was to determin...
- Impact of the DRY Motif and the Missing "Ionic Lock" on Constitutive Activity and G-Protein Coupling of the Human Histamine H-4 Receptor
[作者:Schneider, EH; Schnell, D; Strasser, A; Dove, S; Seifert, R,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:382-392 , 文章类型: Article,,卷期:2010年333-2]
- It is assumed that many G protein-coupled receptors (GPCRs) are restrained in an inactive state by the "ionic lock," an interaction between an arginine in transmembrane domain (TM) 3 (R3.50) and a negatively charged resi...
- A Naphthoquinone Derivative Can Induce Anemia through Phosphatidylserine Exposure-Mediated Erythrophagocytosis
[作者:Noh, JY; Park, JS; Lim, KM; Kim, K; Bae, ON; Chung, SM; Shin, S; Chung, JH,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:414-420 , 文章类型: Article,,卷期:2010年333-2]
- A naphthoquinone derivative, beta-lapachone (beta L; 3,4-dihydro-2,2- dimethyl-2H-naphthol[1,2-b]pyran-5,6-dione), is receiving huge attention for its potent therapeutic effects against various diseases. However, during ...
- A Synthetic 18-Norsteroid Distinguishes between Two Neuroactive Steroid Binding Sites on GABA(A) Receptors
[作者:Evers, AS; Chen, ZW; Manion, BD; Han, MC; Jiang, X; Darbandi-Tonkabon, R; Kable, T; Bracamontes, J; Zorumski, CF; Mennerick, S; Steinbach, JH; Covey, DF,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:404-413 , 文章类型: Article,,卷期:2010年333-2]
- In the absence of GABA, neuroactive steroids that enhance GABA-mediated currents modulate binding of [S-35] t-butylbicyclophosphorothionate in a biphasic manner, with enhancement of binding at low concentrations (site NS...
- Trimetazidine, Administered at the Onset of Reperfusion, Ameliorates Myocardial Dysfunction and Injury by Activation of p38 Mitogen- Activated Protein Kinase and Akt Signaling
[作者:Khan, M; Meduru, S; Mostafa, M; Khan, S; Hideg, K; Kuppusamy, P,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:421-429 , 文章类型: Article,,卷期:2010年333-2]
- Trimetazidine [1-(2,3,4-trimethoxybenzyl) piperazine; TMZ] is an anti-ischemic cardiac drug; however, its efficacy and mechanism of cardioprotection upon reperfusion are largely unknown. The objective of this study was t...
- Anti-Inflammatory Properties of CB1-Receptor Antagonist Involves beta(2) Adrenoceptors
[作者:Mnich, SJ; Hiebsch, RR; Huff, RM; Muthian, S,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:445-453 , 文章类型: Article,,卷期:2010年333-2]
- Antagonists of the cannabinoid receptor 1 (CB1) impart anti-inflammatory activity even though, paradoxically, CB2 receptors are more predominant on cells of the immune system. We attempted to understand the mechanism of ...
- A Novel Sphingosine Kinase Inhibitor Induces Autophagy in Tumor Cells
[作者:Beljanski, V; Knaak, C; Smith, CD,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:454-464 , 文章类型: Article,,卷期:2010年333-2]
- The sphingolipids ceramide, sphingosine, and sphingosine 1-phosphate (S1P) regulate cell signaling, proliferation, apoptosis, and autophagy. Sphingosine kinase-1 and -2 (SK1 and SK2) phosphorylate sphingosine to form S1P...
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