- Against All Odds: Diagnosing Tuberculosis in South Africa
[作者:Wilson, D; Howell, V; Toppozini, C; Dong, K; Clark, M; Hurtado, R,期刊:Journal of Infectious Diseases, 页码:S1102-S1109 , 文章类型: Article,,卷期:2011年204-supl]
- Clinical and logistic systems to support the timely diagnosis of tuberculosis are currently not preventing large numbers of tuberculosis deaths in South Africa. Context-appropriate systems for the diagnosis of tuberculos...
- Interferon-gamma Release Assays for Active Pulmonary Tuberculosis Diagnosis in Adults in Low- and Middle-Income Countries: Systematic Review and Meta-analysis
[作者:Metcalfe, JZ; Everett, CK; Steingart, KR; Cattamanchi, A; Huang, L; Hopewell, PC; Pai, M,期刊:Journal of Infectious Diseases, 页码:S1120-S1129 , 文章类型: Article,,卷期:2011年204-supl]
- Background. The diagnostic value of interferon-gamma release assays (IGRAs) for active tuberculosis in low- and middle-income countries is unclear. Methods. We searched multiple databases for studies published through Ma...
- Adjunctive Tests for Diagnosis of Tuberculosis: Serology, ELISPOT for Site-Specific Lymphocytes, Urinary Lipoarabinomannan, String Test, and Fine Needle Aspiration
[作者:Achkar, JM; Lawn, SD; Moosa, MYS; Wright, CA; Kasprowicz, VO,期刊:Journal of Infectious Diseases, 页码:S1130-S1141 , 文章类型: Article,,卷期:2011年204-supl]
- The diagnostic gold standard for active tuberculosis (TB) is the detection of Mycobacterium tuberculosis (MTB) by culture or molecular methods. However, despite its limited sensitivity, sputum smear microscopy is still t...
- Reporter Phage and Breath Tests: Emerging Phenotypic Assays for Diagnosing Active Tuberculosis, Antibiotic Resistance, and Treatment Efficacy
[作者:Jain, P; Thaler, DS; Maiga, M; Timmins, GS; Bishai, WR; Hatfull, GF; Larsen, MH; Jacobs, WR,期刊:Journal of Infectious Diseases, 页码:S1142-S1150 , 文章类型: Article,,卷期:2011年204-supl]
- The rapid and accurate diagnosis of active tuberculosis (TB) and its drug susceptibility remain a challenge. Phenotypic assays allow determination of antibiotic susceptibilities even if sequence data are not available or...
- Diagnosing Latent Tuberculosis in High-Risk Individuals: Rising to the Challenge in High-Burden Areas
[作者:Kasprowicz, VO; Churchyard, G; Lawn, SD; Squire, SB; Lalvani, A,期刊:Journal of Infectious Diseases, 页码:S1168-S1178 , 文章类型: Article,,卷期:2011年204-supl]
- A key challenge to greater progress in tuberculosis (TB) control is the reservoir of latent TB infection (LTBI), which represents a huge long-lived reservoir of potential TB disease. In parts of Africa, as many as 50% of...
- Real-time Monitoring of Cardiovascular Function in Rhesus Macaques Infected With Zaire ebolavirus
[作者:Kortepeter, MG; Lawler, JV; Honko, A; Bray, M; Johnson, JC; Purcell, BK; Olinger, GG; Rivard, R; Hepburn, MJ; Hensley, LE,期刊:Journal of Infectious Diseases, 页码:S1000-S1010 , 文章类型: Article,,卷期:2011年204-supl]
- Nine rhesus macaques were implanted with multisensor telemetry devices and internal jugular vein catheters before being infected with Zaire ebolavirus. All animals developed viremia, fever, a hemorrhagic rash, and typica...
- VP24 Is a Molecular Determinant of Ebola Virus Virulence in Guinea Pigs
[作者:Mateo, M; Carbonnelle, C; Reynard, O; Kolesnikova, L; Nemirov, K; Page, A; Volchkova, VA; Volchkov, VE,期刊:Journal of Infectious Diseases, 页码:S1011-S1020 , 文章类型: Article,,卷期:2011年204-supl]
- In sharp contrast to human and nonhuman primates, guinea pigs and some other mammals resist Ebola virus (EBOV) replication and do not develop illness upon virus inoculation. However, serial passaging of EBOV in guinea pi...
- Pathogenesis of Marburg Hemorrhagic Fever in Cynomolgus Macaques
[作者:Hensley, LE; Alves, DA; Geisbert, JB; Fritz, EA; Reed, C; Larsen, T; Geisbert, TW,期刊:Journal of Infectious Diseases, 页码:S1021-S1031 , 文章类型: Article,,卷期:2011年204-supl]
- Methods. Eighteen cynomolgus monkeys were infected with MARV; blood and tissues were examined sequentially over an 8-day period to investigate disease pathogenesis. Results. Disease caused by MARV in cynomolgus macaques ...
- Impact of Systemic or Mucosal Immunity to Adenovirus on Ad-Based Ebola Virus Vaccine Efficacy in Guinea Pigs
[作者:Richardson, JS; Abou, MC; Tran, KN; Kumar, A; Sahai, BM; Kobinger, GP,期刊:Journal of Infectious Diseases, 页码:S1032-S1042 , 文章类型: Article,,卷期:2011年204-supl]
- Methods. Guinea pigs administered an adenovirus-based Ebola virus vaccine either intramuscularly or intranasally in the presence of systemically or mucosally induced adenovirus immunity were challenged with a lethal dose...
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