- In Vivo Adipogenesis in Rats Measured by Cell Kinetics in Adipocytes and Plastic-Adherent Stroma-Vascular Cells in Response to High-Fat Diet and Thiazolidinedione
[作者:Tchoukalova, YD; Fitch, M; Rogers, PM; Covington, JD; Henagan, TM; Ye, JP; Hellerstein, MK; Ravussin, E,期刊:Diabetes, 页码:137-144 , 文章类型: Article,,卷期:2012年61-1]
- Impairment of adipogenesis contributes to the development of obesity-related insulin resistance. The current in vitro approaches for its assessment represent crude estimates of the adipogenic potential because of the dis...
- Central Role for Interleukin-2 in Type 1 Diabetes
[作者:Hulme, MA; Wasserfall, CH; Atkinson, MA; Brusko, TM,期刊:Diabetes, 页码:14-22 , 文章类型: Article,,卷期:2012年61-1]
- Type 1 diabetes presents clinically with overt hyperglycemia resulting from progressive immune-mediated destruction of pancreatic beta-cells and associated metabolic dysfunction. Combined genetic and immunological studie...
- Synergistic Reversal of Type 1 Diabetes in NOD Mice With Anti-CD3 and Interleuldn-1 Blockade
[作者:Ablamunits, V; Henegariu, O; Hansen, JB; Opare-Addo, L; Preston-Hurlburt, P; Santamaria, P; Mandrup-Poulsen, T; Herold, KC,期刊:Diabetes, 页码:145-154 , 文章类型: Article,,卷期:2012年61-1]
- Inflammatory cytokines are involved in autoimmune diabetes: among the most prominent is interleukin (IL)-1 beta. We postulated that blockade of IL-1 beta would modulate the effects of anti-CD3 monoclonal antibody (mAb) i...
- Distinguishing Persistent Insulin Autoantibodies With Differential Risk Nonradioactive Bivalent Proinsulin/Insulin Autoantibody Assay
[作者:Yu, LP; Miao, DM; Scrimgeour, L; Johnson, K; Rewers, M; Eisenbarth, GS,期刊:Diabetes, 页码:179-186 , 文章类型: Article,,卷期:2012年61-1]
- A subset of children develops persistent insulin autoantibodies (IAA; almost always as the only islet autoantibody) without evidence of progression to diabetes. The aim of the current study was the development and charac...
- Na(+)-D-glucose Cotransporter SGLT1 is Pivotal for Intestinal Glucose-Absorption and Glucose-Dependent Incretin Secretion
[作者:Gorboulev, V; Schurmann, A; Vallon, V; Kipp, H; Jaschke, A; Klessen, D; Friedrich, A; Scherneck, S; Rieg, T; Cunard, R; Veyhl-Wichmann, M; Srinivasan, A; Balen, D; Breljak, D; Rexhepaj, R; Parker, HE; Gribble, FM; Reimann, F; Lang, F; Wiese, S; Sabolic, I; Sendtner, M; Koepsell, H,期刊:Diabetes, 页码:187-196 , 文章类型: Article,,卷期:2012年61-1]
- To clarify the physiological role of Na(+)-D-glucose cotransporter SGLT1 in small intestine and kidney, Sglt1(-/-) mice were generated and characterized phenotypically. After gavage of D-glucose, small intestinal glucose...
- Somatostatin Receptor Type 2 Antagonism Improves Glucagon and Corticosterone Counterregulatory Responses to Hypoglycemia in Streptozotocin-Induced Diabetic Rats
[作者:Yue, JTY; Burdett, E; Coy, DH; Giacca, A; Efendic, S; Vranic, M,期刊:Diabetes, 页码:197-207 , 文章类型: Article,,卷期:2012年61-1]
- Diminished responsiveness to hypoglycemia contributes to defective counterregulation in diabetes. Pancreatic and/or circulating somatostatin are elevated in diabetes, which may inhibit counterregulatory hormone release d...
- Sirtuin 1-Mediated Cellular Metabolic Memory of High Glucose Via the LKB1/AMPK/ROS Pathway and Therapeutic Effects of Metformin
[作者:Zheng, Z; Chen, HB; Li, J; Li, T; Zheng, BQ; Zheng, Y; Jin, HY; He, Y; Gu, Q; Xu, X,期刊:Diabetes, 页码:217-228 , 文章类型: Article,,卷期:2012年61-1]
- Cellular metabolic memory occurs in diabetic microvascular and macrovascular complications, but the underlying mechanisms remain unclear. Here, we investigate the role of sirtuin 1 (SIRT1) and metformin in this phenomeno...
- Nerve Growth Factor Gene Therapy Using Adeno-Associated Viral Vectors Prevents Cardiomyopathy in Type 1 Diabetic Mice
[作者:Meloni, M; Descamps, B; Caporali, A; Zentilin, L; Floris, I; Giacca, M; Emanueli, C,期刊:Diabetes, 页码:229-240 , 文章类型: Article,,卷期:2012年61-1]
- Diabetes is a cause of cardiac dysfunction, reduced myocardial perfusion, and ultimately heart failure. Nerve growth factor (NGF) exerts protective effects on the cardiovascular system. This study investigated whether NG...
- Nutrient Sensing, Autophagy, and Diabetic Nephropathy
[作者:Kume, S; Thomas, MC; Koya, D,期刊:Diabetes, 页码:23-29 , 文章类型: Article,,卷期:2012年61-1]
- The prevalence of diabetic nephropathy, a serious complication of diabetes, has been increasing worldwide. Therefore, there is an urgent need to identify a new therapeutic target to prevent diabetic nephropathy. "Nutrien...
- The ATP-Sensitive K(+) Channel ABCC8 S1369A Type 2 Diabetes Risk Variant Increases MgATPase Activity
[作者:Fatehi, M; Raja, M; Carter, C; Soliman, D; Holt, A; Light, PE,期刊:Diabetes, 页码:241-249 , 文章类型: Article,,卷期:2012年61-1]
- Pancreatic beta-cell ATP-sensitive K(+) (K(ATP)) channels are composed of Kir6.2 and SUR1 subunits encoded by the KCNJ11 and ABCC8 genes, respectively. Although rare monogenic activating mutations in these genes cause ov...
- Gipr Is Essential for Adrenocortical Steroidogenesis, However, Corticosterone Deficiency Does Not Mediate the Favorable Metabolic Phenotype of Gipr(-/-) Mice
[作者:Bates, HE; Campbell, JE; Ussher, JR; Baggio, LL; Maida, A; Seino, Y; Drucker, DJ,期刊:Diabetes, 页码:40-48 , 文章类型: Article,,卷期:2012年61-1]
- Glucose-dependent insulinotropic polypeptide (GIP) promotes glucose-dependent insulin secretion. However, GIP also enhances glucocorticoid secretion and promotes adiposity. Because obesity and diabetes are glucocorticoid...
- A Novel Mechanism for Regulating Hepatic Glycogen Synthesis Involving Serotonin and Cyclin-Dependent Kinase-5
[作者:Tudhope, SJ; Wang, CC; Petrie, JL; Potts, L; Malcomson, F; Kieswich, J; Yaqoob, MM; Arden, C; Hampson, LJ; Agius, L,期刊:Diabetes, 页码:49-60 , 文章类型: Article,,卷期:2012年61-1]
- Hepatic autonomic nerves regulate postprandial hepatic glucose uptake, but the signaling pathways remain unknown. We tested the hypothesis that serotonin (5-hydroxyhyptamine [5-HT]) exerts stimulatory and inhibitory effe...
- Endoplasmic Reticulum Stress Inhibits STAT3-Dependent Suppression of Hepatic Gluconeogenesis via Dephosphorylation and Deacetylation
[作者:Kimura, K; Yamada, T; Matsumoto, M; Kido, Y; Hosooka, T; Asahara, S; Matsuda, T; Ota, T; Watanabe, H; Sai, Y; Miyamoto, K; Kaneko, S; Kasuga, M; Inoue, H,期刊:Diabetes, 页码:61-73 , 文章类型: Article,,卷期:2012年61-1]
- In the liver, signal transducer and activator of transcription 3 (STAT3) plays an important role in the suppression of gluconeogenic enzyme expression. While obesity-associated endoplasmic reticulum (ER) stress has been ...
- Remodeling of Hepatic Metabolism and Hyperaminoacidemia in Mice Deficient in Proglucagon-Derived Peptides
[作者:Watanabe, C; Seino, Y; Miyahira, H; Yamamoto, M; Fukami, A; Ozaki, N; Takagishi, Y; Sato, J; Fukuwatari, T; Shibata, K; Oiso, Y; Murata, Y; Hayashi, Y,期刊:Diabetes, 页码:74-84 , 文章类型: Article,,卷期:2012年61-1]
- Glucagon is believed to be one of the most important peptides for upregulating blood glucose levels. However, homozygous glucagon green fluorescent protein (gfp) knock-in mice (Gcg(gfp/gfp): GCGKO) are normoglycemic desp...
- Hypothalamic Leucine Metabolism Regulates Liver Glucose Production
[作者:Su, Y; Lam, TKT; He, W; Pocai, A; Bryan, J; Aguilar-Bryan, L; Gutierrez-Juarez, R,期刊:Diabetes, 页码:85-93 , 文章类型: Article,,卷期:2012年61-1]
- Amino acids profoundly affect insulin action and glucose metabolism in mammals. Here, we investigated the role of the mediobasal hypothalamus (MBH), a key center involved in nutrient-dependent metabolic regulation. Speci...
- Targeted Loss of GHR Signaling in Mouse Skeletal Muscle Protects Against High-Fat Diet Induced Metabolic Deterioration
[作者:Vijayakumar, A; Wu, YJ; Sun, H; Li, XS; Jeddy, Z; Liu, CY; Schwartz, GJ; Yakar, S; LeRoith, D,期刊:Diabetes, 页码:94-103 , 文章类型: Article,,卷期:2012年61-1]
- Growth hormone (GH) exerts diverse tissue-specific metabolic effects that are not revealed by global alteration of GH action. To study the direct metabolic effects of GH in the muscle, we specifically inactivated the gro...
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