- Probing Binding Pocket of Serotonin Transporter by Single Molecular Force Spectroscopy on Living Cells
[作者:Wildling, L; Rankl, C; Haselgrubler, T; Gruber, HJ; Holy, M; Newman, AH; Zou, MF; Zhu, R; Freissmuth, M; Sitte, HH; Hinterdorfer, P,期刊:Journal of Biological Chemistry, 页码:105-113 , 文章类型: Article,,卷期:2012年287-1]
- The serotonin transporter (SERT) terminates neurotransmission by removing serotonin from the synaptic cleft. In addition, it is the site of action of antidepressants (which block the transporter) and of amphetamines (whi...
- Identification of Membrane-bound Variant of Metalloendopeptidase Neurolysin (EC 3.4.24.16) as the Non-angiotensin Type 1 (Non-AT1), Non-AT(2) Angiotensin Binding Site
[作者:Wangler, NJ; Santos, KL; Schadock, I; Hagen, FK; Escher, E; Bader, M; Speth, RC; Karamyan, VT,期刊:Journal of Biological Chemistry, 页码:114-122 , 文章类型: Article,,卷期:2012年287-1]
- Recently, we discovered a novel non-angiotensin type 1 (non-AT(1)), non-AT(2) angiotensin binding site in rodent and human brain membranes, which is distinctly different from angiotensin receptors and key proteases proce...
- Polyubiquitination of Transforming Growth Factor beta (TGF beta)-associated Kinase 1 Mediates Nuclear Factor-kappa B Activation in Response to Different Inflammatory Stimuli
[作者:Hamidi, A; von Bulow, V; Hamidi, R; Winssinger, N; Barluenga, S; Heldin, CH; Landstrom, M,期刊:Journal of Biological Chemistry, 页码:123-133 , 文章类型: Article,,卷期:2012年287-1]
- The transcription factor nuclear factor kappa B (NF-kappa B) plays a central role in regulating inflammation in response to several external signals. The TGF beta-associated kinase 1 (TAK1) is an upstream regulator of NF...
- Efflux Permease CgAcr3-1 of Corynebacterium glutamicum Is an Arsenite-specific Antiporter
[作者:Villadangos, AF; Fu, HL; Gil, JA; Messens, J; Rosen, BP; Mateos, LM,期刊:Journal of Biological Chemistry, 页码:723-735 , 文章类型: Article,,卷期:2012年287-1]
- Resistance to arsenite (As(III)) by cells is generally accomplished by arsenite efflux permeases from Acr3 or ArsB unrelated families. We analyzed the function of three Acr3 proteins from Corynebacterium glutamicum, CgAc...
- Binding with Nucleic Acids or Glycosaminoglycans Converts Soluble Protein Oligomers to Amyloid
[作者:Di Domizio, J; Zhang, R; Stagg, LJ; Gagea, M; Zhuo, M; Ladbury, JE; Cao, W,期刊:Journal of Biological Chemistry, 页码:736-747 , 文章类型: Article,,卷期:2012年287-1]
- Ample evidence suggests that almost all polypeptides can either adopt a native structure (folded or intrinsically disordered) or form misfolded amyloid fibrils. Soluble protein oligomers exist as an intermediate between ...
- Identification and Structural Characterization of Novel Cyclotide with Activity against an Insect Pest of Sugar Cane
[作者:Pinto, MFS; Fensterseifer, ICM; Migliolo, L; Sousa, DA; de Capdville, G; Arboleda-Valencia, JW; Colgrave, ML; Craik, DJ; Magalhaes, BS; Dias, SC; Franco, OL,期刊:Journal of Biological Chemistry, 页码:134-147 , 文章类型: Article,,卷期:2012年287-1]
- Cyclotides are a family of plant-derived cyclic peptides comprising six conserved cysteine residues connected by three intermolecular disulfide bonds that form a knotted structure known as a cyclic cystine knot (CCK). Th...
- Lipocalin-2 (24p3/Neutrophil Gelatinase-associated Lipocalin (NGAL)) Receptor Is Expressed in Distal Nephron and Mediates Protein Endocytosis
[作者:Langelueddecke, C; Roussa, E; Fenton, RA; Wolff, NA; Lee, WK; Thevenod, F,期刊:Journal of Biological Chemistry, 页码:159-169 , 文章类型: Article,,卷期:2012年287-1]
- In the kidney, bulk reabsorption of filtered proteins occurs in the proximal tubule via receptor-mediated endocytosis (RME) through the multiligand receptor complex megalin-cubilin. Other mechanisms and nephron sites for...
- Intra-membrane Oligomerization and Extra-membrane Oligomerization of Amyloid-beta Peptide Are Competing Processes as a Result of Distinct Patterns of Motif Interplay
[作者:Zhang, YJ; Shi, JM; Bai, CJ; Wang, H; Li, HY; Wu, Y; Ji, SR,期刊:Journal of Biological Chemistry, 页码:748-756 , 文章类型: Article,,卷期:2012年287-1]
- Soluble oligomers of amyloid-beta peptide (A beta) are emerging as the primary neurotoxic species in Alzheimer disease, however, whether the membrane is among their direct targets that mediate the downstream adverse effe...
- The Ethylmalonyl-CoA Pathway Is Used in Place of the Glyoxylate Cycle by Methylobacterium extorquens AM1 during Growth on Acetate
[作者:Schneider, K; Peyraud, R; Kiefer, P; Christen, P; Delmotte, N; Massou, S; Portais, JC; Vorholt, JA,期刊:Journal of Biological Chemistry, 页码:757-766 , 文章类型: Article,,卷期:2012年287-1]
- Acetyl-CoA assimilation was extensively studied in organisms harboring the glyoxylate cycle. In this study, we analyzed the metabolism of the facultative methylotroph Methylobacterium extorquens AM1, which lacks isocitra...
- Class II ADP-ribosylation Factors Are Required for Efficient Secretion of Dengue Viruses
[作者:Kudelko, M; Brault, JB; Kwok, K; Li, MY; Pardigon, N; Peiris, JSM; Bruzzone, R; Despres, P; Nal, B; Wang, PG,期刊:Journal of Biological Chemistry, 页码:767-777 , 文章类型: Article,,卷期:2012年287-1]
- Identification and characterization of virus-host interactions are very important steps toward a better understanding of the molecular mechanisms responsible for disease progression and pathogenesis. To date, very few ce...
- Enterolobium contortisiliquum Trypsin Inhibitor (EcTI), a Plant Proteinase Inhibitor, Decreases in Vitro Cell Adhesion and Invasion by Inhibition of Src Protein-Focal Adhesion Kinase (FAK) Signaling Pathways
[作者:de Paula, CAA; Coulson-Thomas, VJ; Ferreira, JG; Maza, PK; Suzuki, E; Nakahata, AM; Nader, HB; Sampaio, MU; Oliva, MLV,期刊:Journal of Biological Chemistry, 页码:170-182 , 文章类型: Article,,卷期:2012年287-1]
- Tumor cell invasion is vital for cancer progression and metastasis. Adhesion, migration, and degradation of the extracellular matrix are important events involved in the establishment of cancer cells at a new site, and t...
- Identification and Mechanism of 10-Carbon Fatty Acid as Modulating Ligand of Peroxisome Proliferator-activated Receptors
[作者:Malapaka, RRV; Khoo, S; Zhang, JF; Choi, JH; Zhou, XE; Xu, Y; Gong, YH; Li, J; Yong, EL; Chalmers, MJ; Chang, L; Resau, JH; Griffin, PR; Chen, YE; Xu, HE,期刊:Journal of Biological Chemistry, 页码:183-195 , 文章类型: Article,,卷期:2012年287-1]
- Peroxisome proliferator-activated receptors (PPAR alpha, -beta/delta, and -gamma) are a subfamily of nuclear receptors that plays key roles in glucose and lipid metabolism. PPAR gamma is the molecular target of the thiaz...
- RECQL4, the Protein Mutated in Rothmund-Thomson Syndrome, Functions in Telomere Maintenance
[作者:Ghosh, AK; Rossi, ML; Singh, DK; Dunn, C; Ramamoorthy, M; Croteau, DL; Liu, Y; Bohr, VA,期刊:Journal of Biological Chemistry, 页码:196-209 , 文章类型: Article,,卷期:2012年287-1]
- Telomeres are structures at the ends of chromosomes and are composed of long tracks of short tandem repeat DNA sequences bound by a unique set of proteins (shelterin). Telomeric DNA is believed to form G-quadruplex and D...
- Identification of a New Fatty Acid Synthesis-Transport Machinery at the Peroxisomal Membrane
[作者:Hillebrand, M; Gersting, SW; Lotz-Havla, AS; Schafer, A; Rosewich, H; Valerius, O; Muntau, AC; Gartner, J,期刊:Journal of Biological Chemistry, 页码:210-221 , 文章类型: Article,,卷期:2012年287-1]
- The neurodegenerative disease X-linked adrenoleukodystrophy (X-ALD) is characterized by the abnormal accumulation of very long chain fatty acids. Mutations in the gene encoding the peroxisomal ATP-binding cassette half-t...
|