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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共25条记录   Genome-wide analysis reveals MOF as a key regulator of dosage compensation and gene expression in Drosophila [作者：Kind, J; Vaquerizas, JM; Gebhardt, P; Gentzel, M; Luscombe, NM; Bertone, P; Akhtar, A,期刊：Cell, 页码：813-828 , 文章类型： Article，,卷期：2008年133-5] Dosage compensation, mediated by the MSL complex, regulates X-chromosomal gene expression in Drosophila. Here we report that the histone H4 lysine 16 (H4K16) specific histone acetyltransferase MOF displays differential b... Structure of the DNA repair helicase XPD [作者：Liu, H; Rudolf, J; Johnson, KA; McMahon, SA; Oke, M; Carter, L; McRobbie, AM; Brown, SE; Naismith, JH; White, MF,期刊：Cell, 页码：801-812 , 文章类型： Article，,卷期：2008年133-5] The XPD helicase (Rad3 in Saccharomyces cerevisiae) is a component of transcription factor IIH (TFIIH), which functions in transcription initiation and Nucleotide Excision Repair in eukaryotes, catalyzing DNA duplex open... Capping protein increases the rate of actin-based motility by promoting filament nucleation by the Arp2/3 complex [作者：Akin, O; Mullins, RD,期刊：Cell, 页码：841-851 , 文章类型： Article，,卷期：2008年133-5] Capping protein (CP) is an integral component of Arp2/3-nucleated actin networks that drive amoeboid motility. Increasing the concentration of capping protein, which caps barbed ends of actin filaments and prevents elong... Early sexual origins of homeoprotein heterodimerization and evolution of the plant KNOX/BELL family [作者：Lee, JH; Lin, HW; Joo, S; Goodenough, U,期刊：Cell, 页码：829-840 , 文章类型： Article，,卷期：2008年133-5] Developmental mechanisms that yield multicellular diversity are proving to be well conserved within lineages, generating interest in their origins in unicellular ancestors. We report that molecular regulation of the hapl... Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3 [作者：Sidi, S; Sanda, T; Kennedy, RD; Hagen, AT; Jette, CA; Hoffmans, R; Pascual, J; Imamura, S; Kishi, S; Amatruda, JF; Kanki, JP; Green, DR; D'Andrea, AA; Look, AT,期刊：Cell, 页码：864-877 , 文章类型： Article，,卷期：2008年133-5] Evasion of DNA damage-induced cell death, via mutation of the p53 tumor suppressor or overexpression of prosurvival Bcl-2 family proteins, is a key step toward malignant transformation and therapeutic resistance. We repo... The big brain aquaporin is required for endosome maturation and notch receptor trafficking [作者：Kanwar, R; Fortini, ME,期刊：Cell, 页码：852-863 , 文章类型： Article，,卷期：2008年133-5] Activity of the big brain (bib) gene influences Notch signaling during Drosophila nervous system development. We demonstrate that Bib, which belongs to the aquaporin family of channel proteins, is required for endosome m... Temporal transcription factors and their targets schedule the end of neural proliferation in Drosophila [作者：Maurange, C; Cheng, L; Gould, AP,期刊：Cell, 页码：891-902 , 文章类型： Article，,卷期：2008年133-5] The timing mechanisms responsible for terminating cell proliferation toward the end of development remain unclear. In the Drosophila CNS, individual progenitors called neuroblasts are known to express a series of transcr... The MicroRNA miR-1 regulates a MEF-2-dependent retrograde signal at neuromuscular junctions [作者：Simon, DJ; Madison, JM; Conery, AL; Thompson-Peer, KL; Soskis, M; Ruvkun, GB; Kaplan, JM; Kim, JK,期刊：Cell, 页码：903-915 , 文章类型： Article，,卷期：2008年133-5] We show that miR-1, a conserved muscle-specific microRNA, regulates aspects of both pre- and post-synaptic function at C. elegans neuromuscular junctions. miR-1 regulates the expression level of two nicotinic acetylcholi... Ectodermal factor restricts mesoderm differentiation by inhibiting p53 [作者：Sasai, N; Yakura, R; Kamiya, D; Nakazawa, Y; Sasai, Y,期刊：Cell, 页码：878-890 , 文章类型： Article，,卷期：2008年133-5] During gastrulation of the amphibian embryo, specification of the three germ layers, endo-, ecto-, and mesoderm, is regulated by maternal and zygotic mechanisms. Although it is known that mesoderm specification requires ... Insect odorant receptors: Channeling scent [作者：Ha, TS; Smith, DP,期刊：Cell, 页码：761-763 , 文章类型： Editorial Material，,卷期：2008年133-5] Odorant detection in insects involves heterodimers between an odorant receptor (OR) and a conserved seven-transmembrane protein called Or83b, but the exact mechanism of OR signal transduction is unclear. Two recent studi... Chromatin proteins do double duty [作者：Ercan, S; Lieb, JD,期刊：Cell, 页码：763-765 , 文章类型： Editorial Material，,卷期：2008年133-5] The histone acetyltransferase MOF (males-absent-on-the-first) is required for the regulation of X chromosome gene dosage compensation in Drosophila males. In this issue, Kind et al. (2008) show that MOF is also found on ... Live imaging of neuronal degradation by microglia reveals a role for v0-ATPase a1 in phagosomal fusion in vivo [作者：Peri, F; Nusslein-Volhard, C,期刊：Cell, 页码：916-927 , 文章类型： Article，,卷期：2008年133-5] A significant proportion of neurons in the brain undergo programmed cell death. In order to prevent the diffusion of damaging degradation products, dying neurons are quickly digested by microglia. Despite the importance ... Follow the monomer [作者：Bear, JE,期刊：Cell, 页码：765-767 , 文章类型： Editorial Material，,卷期：2008年133-5] Capping proteins limit actin filament growth, but paradoxically increase actin-based cell motility. This has been attributed to funneling of actin monomers to the filament ends that remain uncapped. Using a reconstituted... p53 regulation orchestrates the TGF-beta response [作者：Piccolo, S,期刊：Cell, 页码：767-769 , 文章类型： Editorial Material，,卷期：2008年133-5] Among its multiple functions, p53 is a critical regulator of TGF-beta responses. Sasai et al. (2008) now identify a new p53 inhibitory protein, XFDL156. During embryonic development, this factor is expressed in the ectod... Plant evolution: TALEs of development [作者：Dolan, L,期刊：Cell, 页码：771-773 , 文章类型： Editorial Material，,卷期：2008年133-5] TALE homeodomain proteins regulate development in many eukaryotes. Now, Lee et al. (2008) report that two TALE homeodomain proteins control zygote development of the unicellular green alga Chlamydomonas. This implicates ... SnapShot: p53 posttranslational modifications - art. no. 930.e1 [作者：Kruse, JP; Gu, W,期刊：Cell, 页码：E1-E1 , 文章类型： Editorial Material，,卷期：2008年133-5]