- Proteomics joins the search for microRNA targets
[作者：Grosshans, H; Filipowicz, W,期刊：Cell, 页码：560-562 , 文章类型： Article，,卷期：2008年134-4]
- Two recent studies published in Nature (Baek et al. 2008; Selbach et al., 2008) analyze changes in the proteome in response to individual microRNAs (miRNAs). This approach is a powerful means to identify miRNA targets an...
- Senescence: Not just for tumor suppression
[作者：Green, MR,期刊：Cell, 页码：562-564 , 文章类型： Article，,卷期：2008年134-4]
- Cellular senescence provides an intrinsic barrier to tumor development by preventing the proliferation of cells that are at risk for malignant transformation. In this issue, Krizhanovsky et al. (2008) report that senesce...
- Gle1 does double duty
[作者：Kutay, U; Panse, VG,期刊：Cell, 页码：564-566 , 文章类型： Article，,卷期：2008年134-4]
- During nuclear export, Gle1 (the nuclear-pore- associated mRNA export factor) activates the DEAD-box protein Dbp5 to remodel exported mRNA-protein complexes on the cytoplasmic face of the nuclear pore complex. In this is...
- Silencing HIV-1 in vivo
[作者：Kirchhoff, F,期刊：Cell, 页码：566-568 , 文章类型： Article，,卷期：2008年134-4]
- RNA interference holds great promise for antiviral therapy, but delivering effective quantities of small interfering RNAs (siRNAs) into the right target cells in vivo represents a major challenge. Kumar et al. (2008) now...
- Linking retroelements to autoimmunity
[作者：Bhoj, VG; Chen, ZJ,期刊：Cell, 页码：569-571 , 文章类型： Article，,卷期：2008年134-4]
- In this issue, Stetson et al. (2008) report a mechanism by which host cells avert an autoimmune response to self-nucleic acids. They show that the nuclease Trex1 prevents the accumulation of DNA derived from endogenous r...
- T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice
[作者：Kumar, P; Ban, HS; Kim, SS; Wu, HQ; Pearson, T; Greiner, DL; Laouar, A; Yao, JH; Haridas, V; Habiro, K; Yang, YG; Jeong, JH; Lee, KY; Kim, YH; Kim, SW; Peipp, M; Fey, GH; Manjunath, N; Shultz, LD; Lee, SK; Shankar, P,期刊：Cell, 页码：577-586 , 文章类型： Article，,卷期：2008年134-4]
- Evaluation of the therapeutic potential of RNAi for HIV infection has been hampered by the challenges of siRNA delivery and lack of suitable animal models. Using a delivery method for T cells, we show that siRNA treatmen...
- A tale of too many centrosomes
[作者：Acilan, C; Saunders, WS,期刊：Cell, 页码：572-575 , 文章类型： Article，,卷期：2008年134-4]
- Having the correct number of centrosomes is crucial for proper chromosome segregation during cell division and for the prevention of aneuploidy, a hallmark of many cancer cells. Several recent studies (Basto et al., 2008...
- Trex1 prevents cell-intrinsic initiation of autoimmunity
[作者：Stetson, DB; Ko, JS; Heidmann, T; Medzhitov, R,期刊：Cell, 页码：587-598 , 文章类型： Article，,卷期：2008年134-4]
- Detection of nucleic acids and induction of type I interferons (IFNs) are principal elements of antiviral defense but can cause autoimmunity if misregulated. Cytosolic DNA detection activates a potent, cell-intrinsic ant...
- Ronin is essential for embryogenesis and the pluripotency of mouse embryonic stem cells (vol 133, pg 1162, 2008)
[作者：Dejosez, M; Krumenacker, JS; Zitur, LJ; Passeri, M; Chu, LF; Zhou, SY; Thomson, JA; Zwaka, TP,期刊：Cell, 页码：692-692 , 文章类型： Correction，,卷期：2008年134-4]
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- The regulation and evolution of a genetic switch controlling sexually dimorphic traits in Drosophila
[作者：Williams, TM; Selegue, JE; Werner, T; Gompel, N; Kopp, A; Carroll, SB,期刊：Cell, 页码：610-623 , 文章类型： Article，,卷期：2008年134-4]
- Sexually dimorphic traits play key roles in animal evolution and behavior. Little is known, however, about the mechanisms governing their development and evolution. One recently evolved dimorphic trait is the male-specif...
- A sequence motif within chromatin entry sites directs MSL establishment on the Drosophila X chromosome
[作者：Alekseyenko, AA; Peng, SY; Larschan, E; Gorchakov, AA; Lee, OK; Kharchenko, P; McGrath, SD; Wang, CI; Mardis, ER; Park, PJ; Kuroda, MI,期刊：Cell, 页码：599-609 , 文章类型： Article，,卷期：2008年134-4]
- The Drosophila MSL complex associates with active genes specifically on the male X chromosome to acetylate histone H4 at lysine 16 and increase expression approximately 2-fold. To date, no DNA sequence has been discovere...
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