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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共21条记录   Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation [作者：Buis, J; Wu, YP; Deng, YB; Leddon, J; Westfield, G; Eckersdorff, M; Sekiguchi, JM; Chang, S; Ferguson, DO,期刊：Cell, 页码：85-96 , 文章类型： Article，,卷期：2008年135-1] The Mre11/Rad50/NBS1 (MRN) complex maintains genomic stability by bridging DNA ends and initiating DNA damage signaling through activation of the ATM kinase. Mre11 possesses DNA nuclease activities that are highly conser... Dynamic control of the DNA replication initiation protein DnaA by Soj/ParA [作者：Murray, H; Errington, J,期刊：Cell, 页码：74-84 , 文章类型： Article，,卷期：2008年135-1] Regulation of DNA replication and segregation is essential for all cells. Orthologs of the plasmid partitioning genes parA, parB, and parS are present in bacterial genomes throughout the prokaryotic evolutionary tree and... Structural and mechanistic insights into STIM1-mediated initiation of store-operated calcium entry [作者：Stathopulos, PB; Zheng, L; Li, GY; Plevin, MJ; Ikura, M,期刊：Cell, 页码：110-122 , 文章类型： Article，,卷期：2008年135-1] Stromal interaction molecule-1 (STIM1) activates store-operated Ca2+ entry (SOCE) in response to diminished luminal Ca2+ levels. Here, we present the atomic structure of the Ca2+-sensing region of STIM1 consisting of the... Mre11 dimers coordinate DNA end bridging and nuclease processing in double-strand-break repair [作者：Williams, RS; Moncalian, G; Williams, JS; Yamada, Y; Limbo, O; Shin, DS; Groocock, LM; Cahill, D; Hitomi, C; Guenther, G; Moiani, D; Carney, JP; Russell, P; Tainer, JA,期刊：Cell, 页码：97-109 , 文章类型： Article，,卷期：2008年135-1] Mre11 forms the core of the multifunctional Mre11-Rad50-Nbs1 (MRN) complex that detects DNA double-strand breaks (DSBs), activates the ATM checkpoint kinase, and initiates homologous recombination (HR) repair of DSBs. To... ACF7 regulates cytoskeletal-focal adhesion dynamics and migration and has ATPase activity [作者：Wu, XY; Kodama, A; Fuchs, E,期刊：Cell, 页码：137-148 , 文章类型： Article，,卷期：2008年135-1] Coordinated interactions between microtubule (MT) and actin cytoskeletons are involved in many polarized cellular processes. Spectraplakins are enormous (>500 kDa) proteins able to bind both MTs and actin filaments (F-ac... A tripartite complex containing MRCK modulates lamellar actomyosin retrograde flow [作者：Tan, I; Yong, J; Dong, JM; Lim, L; Leung, T,期刊：Cell, 页码：123-136 , 文章类型： Article，,卷期：2008年135-1] Actomyosin retrograde flow underlies the contraction essential for cell motility. Retrograde flow in both lamellipodia and lamella is required for membrane protrusion and for force generation by coupling to cell adhesion... Linking cell cycle to asymmetric division: Aurora-A phosphorylates the par complex to regulate Numb localization [作者：Wirtz-Peitz, F; Nishimura, T; Knoblich, JA,期刊：Cell, 页码：161-173 , 文章类型： Article，,卷期：2008年135-1] Drosophila neural precursor cells divide asymmetrically by segregating the Numb protein into one of the two daughter cells. Numb is uniformly cortical in interphase but assumes a polarized localization in mitosis. Here, ... Global transcriptional repression in C-elegans germline precursors by regulated sequestration of TAF-4 [作者：Guven-Ozkan, T; Nishi, Y; Robertson, SM; Lin, RL,期刊：Cell, 页码：149-160 , 文章类型： Article，,卷期：2008年135-1] In C. elegans, four asymmetric divisions, beginning with the zygote (P0), generate transcriptionally repressed germline blastomeres (P1-P4) and somatic sisters that become transcriptionally active. The protein PIE-1 repr... Senescence of activated stellate cells limits liver fibrosis (vol 134, pg 657, 2008) [作者：Krizhanovsky, V; Yon, M; Dickins, RA; Hearn, S; Simon, J; Miething, C; Yee, H; Zender, L; Lowe, SW,期刊：Cell, 页码：190-190 , 文章类型： Correction，,卷期：2008年135-1] Systematic genetic analysis of virulence in the human fungal pathogen Cryptococcus neoformans [作者：Liu, OW; Chun, CD; Chow, ED; Chen, CB; Madhani, HD; Noble, SM,期刊：Cell, 页码：174-188 , 文章类型： Article，,卷期：2008年135-1] The fungus Cryptococcus neoformans is a leading cause of mortality and morbidity among HIV-infected individuals. We utilized the completed genome sequence and optimized methods for homologous DNA replacement using high-v... AMPK and PPAR delta agonists are exercise mimetics (vol 134, pg 405, 2008) [作者：Narkar, VA; Downes, M; Yu, RT; Embler, E; Wang, YX; Banayo, E; Mihaylova, MM; Nelson, MC; Zou, YH; Juguilon, H; Kang, HJ; Shaw, RJ; Evans, RM,期刊：Cell, 页码：189-189 , 文章类型： Correction，,卷期：2008年135-1] The meaning of gene positioning [作者：Takizawa, T; Meaburn, KJ; Misteli, T,期刊：Cell, 页码：9-13 , 文章类型： Editorial Material，,卷期：2008年135-1] There is no doubt that genomes are organized nonrandomly in the nucleus of higher eukaryotes. But what is the functional relevance of this nonrandomness? In this Essay, we explore the biological meaning of spatial gene p... DNA repair by the MRN complex: Break it to make it [作者：Kanaar, R; Wyman, C,期刊：Cell, 页码：14-16 , 文章类型： Editorial Material，,卷期：2008年135-1] Genomic instability in ataxia telangiectasia-like disorder and Nijmegen breakage syndrome is due to disruption of the Mre11-Rad50-Nbs1 complex. Buis et al. (2008) and Williams et al. (2008) now reveal the importance of t... Spectraplakins: The cytoskeleton's swiss army knife [作者：Brown, NH,期刊：Cell, 页码：16-18 , 文章类型： Editorial Material，,卷期：2008年135-1] Spectraplakins are multifunctional proteins that interact with all three types of cytoskeletal filaments. In this issue, Wu et al. (2008) demonstrate a new actin-dependent ATPase activity for the spectraplakin ACF7 that ... OMA-gosh, where's that TAF? [作者：Blackwell, TK; Walker, AK,期刊：Cell, 页码：18-20 , 文章类型： Editorial Material，,卷期：2008年135-1] How transcription is silenced in early embryos has long been a mystery. In this issue, Guven-Ozkan et al. (2008) report that transcriptional repression during worm embryogenesis is mediated through sequestration of the g... Stressing the brain, fattening the body [作者：Yang, L; Hotamisligil, GS,期刊：Cell, 页码：20-22 , 文章类型： Editorial Material，,卷期：2008年135-1] Obesity is characterized by chronic activation of inflammatory pathways in peripheral tissues. In this issue, Zhang et al. (2008) demonstrate that inflammation also occurs in the central nervous system where it disrupts ...