- An Analog of BIX-01294 Selectively Inhibits a Family of Histone H3 Lysine 9 Jumonji Demethylases
[作者:Upadhyay, AK; Rotili, D; Han, JW; Hu, RG; Chang, YQ; Labella, D; Zhang, X; Yoon, YS; Mai, A; Cheng, XD,期刊:Journal of Molecular Biology, 页码:319-327 , 文章类型: Article,,卷期:2012年416-3]
- BIX-01294 and its analogs were originally identified and subsequently designed as potent inhibitors against histone H3 lysine 9 (H3K9) methyltransferases G9a and G9a-like protein. Here, we show that BIX-01294 and its ana...
- Thermodynamic Measurements of Bilayer Insertion of a Single Transmembrane Helix Chaperoned by Fluorinated Surfactants
[作者:Kyrychenko, A; Rodnin, MV; Posokhov, YO; Holt, A; Pucci, B; Killian, JA; Ladokhin, AS,期刊:Journal of Molecular Biology, 页码:328-334 , 文章类型: Article,,卷期:2012年416-3]
- Accurate determination of the free energy of transfer of a helical segment from an aqueous into a transmembrane (TM) conformation is essential for understanding and predicting the folding and stability of membrane protei...
- Estimating the Size of the Active Translocation Pore of an Autotransporter
[作者:Sauri, A; ten Hagen-Jongman, CM; van Ulsen, P; Luirink, J,期刊:Journal of Molecular Biology, 页码:335-345 , 文章类型: Article,,卷期:2012年416-3]
- Autotransporters (ATs) are large virulence factors secreted by Gram-negative bacteria. The passenger domain, carrying the virulence functions, is transported across the bacterial outer membrane in a step that is facilita...
- Subcellular Distribution of the Human Putative Nucleolar GTPase GNL1 is Regulated by a Novel Arginine/Lysine-Rich Domain and a GTP Binding Domain in a Cell Cycle-Dependent Manner
[作者:Boddapati, N; Anbarasu, K; Suryaraja, R; Tendulkar, AV; Mahalingam, S,期刊:Journal of Molecular Biology, 页码:346-366 , 文章类型: Article,,卷期:2012年416-3]
- GNL1, a putative nucleolar GTPase, belongs to the MMR1-HSR1 family of large GTPases that are emerging as crucial coordinators of signaling cascades in different cellular compartments. Members of this family share very cl...
- Temporal Regulation of Gene Expression of the Escherichia coli Bacteriophage phiEco32
[作者:Pavlova, O; Lavysh, D; Klimuk, E; Djordjevic, M; Liavcheev, DA; Gelfand, MS; Severinov, K; Akulenko, N,期刊:Journal of Molecular Biology, 页码:389-399 , 文章类型: Article,,卷期:2012年416-3]
- Escherichia coli phage phiEco32 encodes two proteins that bind to host RNA polymerase (RNAP): gp79, a novel protein, and gp36, a distant homolog of sigma(70) family proteins. Here, we investigated the temporal pattern of...
- Metal Binding Dictates Conformation and Function of the Amyloid Precursor Protein (APP) E2 Domain
[作者:Dahms, SO; Konnig, I; Roeser, D; Guhrs, KH; Mayer, MC; Kaden, D; Multhaup, G; Than, ME,期刊:Journal of Molecular Biology, 页码:438-452 , 文章类型: Article,,卷期:2012年416-3]
- The amyloid precursor protein (APP) and its neurotoxic cleavage product A beta are key players in the development of Alzheimer's disease and appear essential for neuronal development and cell homeostasis in mammals. Prot...
- Malleability of the Folding Mechanism of the Outer Membrane Protein PagP: Parallel Pathways and the Effect of Membrane Elasticity
[作者:Huysmans, GHM; Radford, SE; Baldwin, SA; Brockwell, DJ,期刊:Journal of Molecular Biology, 页码:453-464 , 文章类型: Article,,卷期:2012年416-3]
- Understanding the interactions between membrane proteins and the lipid bilayer is key to increasing our ability to predict and tailor the folding mechanism, structure and stability of membrane proteins. Here, we have inv...
|