- A Protein Arginine N-Methyltransferase 1 (PRMT1) and 2 Heteromeric Interaction Increases PRMT1 Enzymatic Activity
[作者:Pak, ML; Lakowski, TM; Thomas, D; Vhuiyan, MI; Husecken, K; Frankel, A,期刊:Biochemistry, 页码:8226-8240 , 文章类型: Article,,卷期:2011年50-38]
- Protein arginine N-methyltransferases (PRMTs) act in signaling pathways and gene expression by methylating arginine residues within target proteins. PRMT1 is responsible for most cellular arginine methylation activity an...
- Comparative Hydrogen-Deuterium Exchange for a Mesophilic vs Thermophilic Dihydrofolate Reductase at 25 degrees C: Identification of a Single Active Site Region with Enhanced Flexibility in the Mesophilic Protein
[作者:Oyeyemi, OA; Sours, KM; Lee, T; Kohen, A; Resing, KA; Ahn, NG; Klinman, JP,期刊:Biochemistry, 页码:8251-8260 , 文章类型: Article,,卷期:2011年50-38]
- The technique of hydrogen deuterium exchange coupled to mass spectrometry (HDX-MS) has been applied to a mesophilic (E. coli) dihydrofolate reductase under conditions that allow direct comparison to a thermophilic (B. st...
- Structural Basis of the Substrate Specificity of Bifunctional Isocitrate Dehydrogenase Kinase/Phosphatase
[作者:Yates, SP; Edwards, TE; Bryan, CM; Stein, AJ; Van Voorhis, WC; Myler, PJ; Stewart, LJ; Zheng, JM; Jia, ZC,期刊:Biochemistry, 页码:8103-8106 , 文章类型: Article,,卷期:2011年50-38]
- Isocitrate dehydrogenase kinase/phosphatase (AceK) regulates entry into the glyoxylate bypass by reversibly phosphorylating isocitrate dehydrogenase (ICDH). On the basis of the recently determined structure of the AceK I...
- Mass Spectrometry-Based Protein Footprinting Characterizes the Structures of Oligorneric Apolipoprotein E2, E3, and E4
[作者:Gau, B; Garai, K; Frieden, C; Gross, ML,期刊:Biochemistry, 页码:8117-8126 , 文章类型: Article,,卷期:2011年50-38]
- The three common isoforms of apolipoprotein E (ApoE) differ at two sites in their 299 amino acid sequence; these differences modulate the structure of ApoE to affect profoundly the isoform associations with disease. The ...
- Light-Controlled Protein Dynamics Observed with Neutron Spin Echo Measurements
[作者:Wang, SC; Mirarefi, P; Faraone, A; Lee, CT,期刊:Biochemistry, 页码:8150-8162 , 文章类型: Article,,卷期:2011年50-38]
- A photoresponsive surfactant has been used as a means to control protein structure and dynamics with light illumination. This cationic azobenzene surfactant, azoTAB, which undergoes a reversible photoisomerization upon e...
- Blue Flickers of Hope: Secondary Structure, Dynamics, and Putative Dimerization Interface of the Blue-Light Receptor YtvA from Bacillus subtilis
[作者:Jurk, M; Dorn, M; Schmieder, P,期刊:Biochemistry, 页码:8163-8171 , 文章类型: Article,,卷期:2011年50-38]
- Bacillus subtilis is capable of responding to various kinds of extracellular, potentially harmful stimuli via a stress response pathway, which involves a signal transduction and integration hub, the stressosome, and fina...
- Amphitrite ornata Dehaloperoxidase (DHP): Investigations of Structural Factors That Influence the Mechanism of Halophenol Dehalogenation Using "Peroxidase-like" Myoglobin Mutants and "Myoglobin-like" DHP Mutants
[作者:Du, J; Huang, X; Sun, SF; Wang, CX; Lebioda, L; Dawson, JH,期刊:Biochemistry, 页码:8172-8180 , 文章类型: Article,,卷期:2011年50-38]
- Dehaloperoxidase (DHP), discovered in the marine terebellid polychaete Amphitrite ornata, is the first heme-containing globin with a peroxidase activity. The sequence and crystal structure of DHP argue that it evolved fr...
- Lactam Constraints Provide Insights into the Receptor-Bound Conformation of Secretin and Stabilize a Receptor Antagonist
[作者:Dong, MQ; Te, JA; Xu, XQ; Wang, JH; Pinon, DI; Storjohann, L; Bordner, AJ; Miller, LJ,期刊:Biochemistry, 页码:8181-8192 , 文章类型: Article,,卷期:2011年50-38]
- The natural ligands for family B G protein-coupled receptors are moderate-length linear peptides having diffuse pharmacophores. The amino-terminal regions of these ligands are critical for biological activity, with their...
- Generation of Autonomous Activity of Ca(2+)/Calmodulin-Dependent Protein Kinase Kinase beta by Autophosphorylation
[作者:Tokumitsu, H; Hatano, N; Fujimoto, T; Yurimoto, S; Kobayashi, R,期刊:Biochemistry, 页码:8193-8201 , 文章类型: Article,,卷期:2011年50-38]
- Ca(2+)/calmodulin-dependent protein kinase kinases (CaMKKs) phosphorylate and activate specific downstream protein kinases, including CaMKI, CaMKIV, and 5'-AMP-activated protein kinase, which mediates a variety of Ca(2+)...
- Designed Hairpin Peptides Interfere with Amyloidogenesis Pathways: Fibril Formation and Cytotoxicity Inhibition, Interception of the Preamyloid State
[作者:Huggins, KNL; Bisaglia, M; Bubacco, L; Tatarek-Nossol, M; Kapurniotu, A; Andersen, NH,期刊:Biochemistry, 页码:8202-8212 , 文章类型: Article,,卷期:2011年50-38]
- Hairpin peptides bearing cross-strand Trp-Trp and Tyr-Tyr pairs at non-H-bonded strand sites modulate the aggregation of two unrelated amyloidogenic systems, human pancreatic amylin (hAM) and a-synuclein (alpha-syn), ass...
- Structure-Guided Engineering of a Pacific Blue Fluorophore Ligase for Specific Protein Imaging in Living Cells
[作者:Cohen, JD; Thompson, S; Ting, AY,期刊:Biochemistry, 页码:8221-8225 , 文章类型: Article,,卷期:2011年50-38]
- Mutation of a gatekeeper residue, tryptophan 37, in E. coli lipoic acid ligase (LplA), expands substrate specificity such that unnatural probes much larger than lipoic acid can be recognized. This approach, however, has ...
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