个性化文献订阅>文章检索

文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共24条记录   Unravelling the Conformational Plasticity of the Extracellular Domain of a Prokaryotic nAChR Homologue in Solution by NMR [作者：Chasapis, CT; Argyriou, AI; Corringer, PJ; Bentrop, D; Spyroulias, GA,期刊：Biochemistry, 页码：9681-9683 , 文章类型： Article，,卷期：2011年50-45] Pentameric ligand-gated ion channels (pLGICs) of the Cys loop family are transmembrane glycoproteins implicated in a variety of biological functions. Here, we present a solution NMR study of the extracellular domain of a... Lactose Permease and the Alternating Access Mechanism [作者：Smirnova, I; Kasho, V; Kaback, HR,期刊：Biochemistry, 页码：9684-9693 , 文章类型： Article，,卷期：2011年50-45] Crystal structures of the lactose permease of Escherichia coli (LacY) reveal 12, mostly irregular transmembrane a-helices surrounding a large cavity open to the cytoplasm and a tightly sealed periplasmic side (inward-fac... Aging Enhances the Production of Reactive Oxygen Species and Bactericidal Activity in Peritoneal Macrophages by Upregulating Classical Activation Pathways [作者：Smallwood, HS; Lopez-Ferrer, D; Squier, TC,期刊：Biochemistry, 页码：9911-9922 , 文章类型： Article，,卷期：2011年50-45] Maintenance of macrophages in their basal state and their rapid activation in response to pathogen detection are central to the innate immune system, acting to limit nonspecific oxidative damage and promote pathogen kill... Peptide-Derivatized Albumins That Inhibit Fibrin Polymerization [作者：Watson, JW; Doolittle, RF,期刊：Biochemistry, 页码：9923-9927 , 文章类型： Article，,卷期：2011年50-45] Synthetic peptides patterned on sequences that appear during thrombin proteolysis of fibrinogen are known to influence fibrin formation in very different ways. A-Knob sequences (GPR-) inhibit polymerization, but B-knob s... Myotonic Dystrophy Type 1 RNA Crystal Structures Reveal Heterogeneous 1 x 1 Nucleotide UU Internal Loop Conformations [作者：Kumar, A; Park, H; Fang, PF; Parkesh, R; Guo, M; Nettles, KW; Disney, MD,期刊：Biochemistry, 页码：9928-9935 , 文章类型： Article，,卷期：2011年50-45] RNA internal loops often display a variety of conformations in solution. Herein, we visualize conformational heterogeneity in the context of the 5'CUG/3'GUC repeat motif present in the RNA that causes myotonic dystrophy ... Activation and Inhibition of Pyruvate Carboxylase from Rhizobium etli [作者：Zeczycki, TN; Menefee, AL; Jitrapakdee, S; Wallace, JC; Attwood, PV; St Maurice, M; Cleland, WW,期刊：Biochemistry, 页码：9694-9707 , 文章类型： Article，,卷期：2011年50-45] While crystallographic structures of the R. etli pyruvate carboxylase (PC) holoenzyme revealed the location and probable positioning of the essential activator, Mg(2+), and nonessential activator, acetyl-CoA, an understa... Interaction between the Biotin Carboxyl Carrier Domain and the Biotin Carboxylase Domain in Pyruvate Carboxylase from Rhizobium etli [作者：Lietzan, AD; Menefee, AL; Zeczycki, TN; Kumar, S; Attwood, PV; Wallace, JC; Cleland, WW; St Maurice, M,期刊：Biochemistry, 页码：9708-9723 , 文章类型： Article，,卷期：2011年50-45] Pyruvate carboxylase (PC) catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate, an important anaplerotic reaction in mammalian tissues. To effect catalysis, the tethered biotin of PC must gain access to ... Novel Insights into the Biotin Carboxylase Domain Reactions of Pyruvate Carboxylase from Rhizobium etli [作者：Zeczycki, TN; Menefee, AL; Adina-Zada, A; Jitrapakdee, S; Surinya, KH; Wallace, JC; Attwood, PV; St Maurice, M; Cleland, WW,期刊：Biochemistry, 页码：9724-9737 , 文章类型： Article，,卷期：2011年50-45] The catalytic mechanism of the MgATP-dependent carboxylation of biotin in the biotin carboxylase domain of pyruvate carboxylase from R etli (RePC) is common to the biotin-dependent carboxylases. The current site-directed... Targeted Protein Degradation of Outer Membrane Decaheme Cytochrome MtrC Metal Reductase in Shewanella oneidensis MR-1 Measured Using Biarsenical Probe CrAsH-EDT(2) [作者：Xiong, YJ; Chen, BW; Shi, L; Fredrickson, JK; Bigelow, DJ; Squier, TC,期刊：Biochemistry, 页码：9738-9751 , 文章类型： Article，,卷期：2011年50-45] Development of efficient microbial biofuel cells requires an ability to exploit interfacial electron transfer reactions to external electron acceptors, such as metal oxides; such reactions occur in the facultative anaero... Isolated Hb Providence beta 82Asn and beta 82Asp Fractions Are More Stable than Native HbA(0) under Oxidative Stress Conditions [作者：Abraham, B; Hicks, W; Jia, YP; Baek, JH; Miller, JL; Alayash, AI,期刊：Biochemistry, 页码：9752-9766 , 文章类型： Article，,卷期：2011年50-45] We have previously shown that hydrogen peroxide (H(2)O(2)) triggers irreversible oxidation of amino acids exclusive to the beta-chains of purified human hemoglobin (HbAo). However, it is not clear, whether alpha- or beta... The Inactivating Factor of Glutamine Synthetase IF17 Is an Intrinsically Disordered Protein, Which Folds upon Binding to Its Target [作者：Saelices, L; Galmozzi, CV; Florencio, FJ; Muro-Pastor, MI; Neira, JL,期刊：Biochemistry, 页码：9767-9778 , 文章类型： Article，,卷期：2011年50-45] In cyanobacteria, ammonium is incorporated into carbon skeletons by the sequential action of glutamine synthetase and glutamate synthase (GOGAT). The activity of Synechocystis sp. PCC 6803 glutamine synthetase type I (GS... Structural Transitions of Translation Initiation Factor IF2 upon GDPNP and GDP Binding in Solution [作者：Rasmussen, LCV; Oliveira, CLP; Pedersen, JS; Sperling-Petersen, HU; Mortensen, KK,期刊：Biochemistry, 页码：9779-9787 , 文章类型： Article，,卷期：2011年50-45] Three protein factors ensure rapid and accurate initiation of translation in bacteria. Translation initiation factor IF2 is a ribosome-dependent GTPase, which is important for correct positioning of initiator tRNA on the... The HIV-1 Integrase Monomer Induces a Specific Interaction with LTR DNA for Concerted Integration [作者：Pandey, KK; Bera, S; Grandgenett, DP,期刊：Biochemistry, 页码：9788-9796 , 文章类型： Article，,卷期：2011年50-45] The assembly mechanism for the human immunodeficiency virus type 1 (HIV) synaptic complex (SC) capable of concerted integration is unknown. Molecular and structural studies have established that the HIV SC and prototype ... Properties of the Monomeric Form of Human 14-3-3 zeta Protein and Its Interaction with Tau and HspB6 [作者：Sluchanko, NN; Sudnitsyna, MV; Seit-Nebi, AS; Antson, AA; Gusev, NB,期刊：Biochemistry, 页码：9797-9808 , 文章类型： Article，,卷期：2011年50-45] Dimers formed by seven isoforms of the human 14-3-3 protein participate in multiple cellular processes. The dimeric form has been extensively characterized; however, little is known about the structure and properties of ... Distinguishing Amyloid Fibril Structures in Alzheimer's Disease (AD) by Two-Dimensional Ultraviolet (2DUV) Spectroscopy [作者：Lam, AR; Jiang, J; Mukamel, S,期刊：Biochemistry, 页码：9809-9816 , 文章类型： Article，,卷期：2011年50-45] Understanding the aggregation mechanism of amyloid fibrils and characterizing their structures are important steps in the investigation of several neurodegenerative disorders associated with the misfolding of proteins. W... Assessment of a Fully Active Class A G Protein-Coupled Receptor Isolated from in Vitro Folding [作者：Bosse, M; Thomas, L; Hassert, R; Beck-Sickinger, AG; Huster, D; Schmidt, P,期刊：Biochemistry, 页码：9817-9825 , 文章类型： Article，,卷期：2011年50-45] We provide a protocol for the preparation of fully active Y2 G protein-coupled receptors (GPCRs). Although a valuable target for pharmaceutical research, information about the structure and dynamics of these molecules re...