- The evolution of MDM2 family genes
[作者:Momand, J; Villegas, A; Belyi, VA,期刊:Gene, 页码:23-30 , 文章类型: Article,,卷期:2011年486-40910]
- MDM2 and MDM4 are proto-oncoproteins that bind to and inhibit members of the p53 protein family, p53, p73 and possibly p63. p53 is a mammalian tumor suppressor and p63 and p73 are critical for development. With the seque...
- Pseudotrisomy 13 syndrome: Use of homozygosity mapping to target candidate genes
[作者:Marquis-Nicholson, R; Aftimos, S; Ashton, F; Love, JM; Stone, P; McFarlane, J; George, AM; Love, DR,期刊:Gene, 页码:37-40 , 文章类型: Article,,卷期:2011年486-40910]
- Pseudotrisomy 13 syndrome is characterised by holoprosencephaly with or without polydactyly, but with a normal karyotype. The genetic cause of this syndrome remains unclear, but it is thought to be autosomal recessive. I...
- Molecular cloning and expression of a cucumber (Cucumis sativus L.) heme oxygenase-1 gene, CsHO1, which is involved in adventitious root formation
[作者:Li, MY; Cao, ZY; Shen, WB; Cui, J,期刊:Gene, 页码:47-55 , 文章类型: Article,,卷期:2011年486-40910]
- Our previous work showed that in cucumber (Cucumis sativus), auxin rapidly induces heme oxygenase (HO) activity and the product of HO action, carbon monoxide (CO), then triggers the signal transduction events leading to ...
- Transcriptional repression by the proximal exonic region at the human TERT gene
[作者:Wong, TC; Sokol, ES; Schep, AN; Punjiya, M; Tran, DA; Allan, D; Drewell, RA,期刊:Gene, 页码:65-73 , 文章类型: Article,,卷期:2011年486-40910]
- In humans, the enzyme telomerase (hTERT) is responsible for the synthesis of new repeat sequences at the telomeres of chromosomes. Although active in early embryogenesis, the hTERT gene is transcriptionally silenced in a...
- RhoBTB2 (DBC2) functions as tumor suppressor via inhibiting proliferation, preventing colony formation and inducing apoptosis in breast cancer cells
[作者:Mao, HT; Zhang, LN; Yang, YM; Sun, JT; Deng, BP; Feng, JB; Shao, QQ; Feng, AE; Song, BF; Qu, X,期刊:Gene, 页码:74-80 , 文章类型: Article,,卷期:2011年486-40910]
- RhoBTB2 was isolated recently as a tumor suppressor gene from sporadic breast cancer. Although RhoBTB2 was found to be frequently lost in breast cancer and a variety of cancers, its antitumor effect, however, remains unc...
- Molecular mechanism underlying the differential MYF6 expression in postnatal skeletal muscle of Duroc and Pietrain breeds
[作者:Fan, HT; Cinar, MU; Phatsara, C; Tesfaye, D; Tholen, E; Looft, C; Schellander, K,期刊:Gene, 页码:8-14 , 文章类型: Article,,卷期:2011年486-40910]
- Among modern western pigs, Duroc (high meat fat ratio) and Pietrain (low meat fat ratio) breeds extensively utilized in commercial pork production differ extremely for their muscle phenotypes. The molecular mechanism, es...
- Transcriptional and epigenetic effects of deleting large regions, alone or in combination, from their natural context in the chicken Ig-beta gene
[作者:Chayahara, K; Itaya, K; Ono, M,期刊:Gene, 页码:1-7 , 文章类型: Article,,卷期:2011年486-40910]
- Previously, we used homologous recombination to delete six groups of cell-type-specific DNase I hypersensitive sites (DHSs), potential transcriptional and epigenetic regulators, scattered in and around the Ig-beta gene f...
- No association of pre-microRNA-146a rs2910164 polymorphism and risk of hepatocellular carcinoma development in Turkish population: A case-control study
[作者:Akkiz, H; Bayram, S; Bekar, A; Akgollu, E; Uskudar, O; Sandikci, M,期刊:Gene, 页码:104-109 , 文章类型: Article,,卷期:2011年486-40910]
- Aim: MicroRNAs (miRNAs) are an abundant class of small non-protein coding RNAs with posttranscriptional regulatory functions as tumor suppressors and oncogenes. Aberrant expression and structural alteration of miRNAs are...
- Protein map: An alignment-free sequence comparison method based on various properties of amino acids
[作者:Yu, CL; Cheng, SY; He, RL; Yau, SST,期刊:Gene, 页码:110-118 , 文章类型: Article,,卷期:2011年486-40910]
- In this paper, we propose a new protein map which incorporates with various properties of amino acids. As a powerful tool for protein classification, this new protein map both considers phylogenetic factors arising from ...
- Evaluation of Sox2 genetic effect on the development of type 2 diabetes
[作者:Gu, HF; Gu, T; Ostenson, CG; Karvestedt, L; Brismar, K,期刊:Gene, 页码:94-96 , 文章类型: Article,,卷期:2011年486-40910]
- Sox2 is a transcription factor, which plays an important role in the induction of pluripotent stem cells from somatic cells. The Sox2 gene is located in chromosome 3q26.33 and resides in a linkage region of diabetes. In ...
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