- Zfp143 Regulates Nanog Through Modulation of Oct4 Binding
[作者:Chen, X; Fang, F; Liou, YC; Ng, HH,期刊:Stem Cells, 页码:2759-2767 , 文章类型: Article,,卷期:2008年26-11]
- Identification of regulators governing the maintenance of embryonic stem (ES) cells is crucial to the understanding of ES cell biology. We identified a zinc finger protein, Zfp143, as a novel regulator for self-renewal. ...
- Enrichment and Differentiation of Human Germ-Like Cells Mediated by Feeder Cells and Basic Fibroblast Growth Factor Signaling
[作者:West, FD; Machacek, DW; Boyd, NL; Pandiyan, K; Robbins, KR; Stice, SL,期刊:Stem Cells, 页码:2768-2776 , 文章类型: Article,,卷期:2008年26-11]
- Human embryonic stem cells (hESCs) have recently demonstrated the potential for differentiation into germ-like cells in vitro. This provides a novel model for understanding human germ cell development and human infertili...
- Feeder-Free Monolayer Cultures of Human Embryonic Stem Cells Express an Epithelial Plasma Membrane Protein Profile
[作者:Van Hoof, D; Braam, SR; Dormeyer, W; Oostwaard, DWV; Heck, AJR; Krijgsveld, J; Mummery, CL,期刊:Stem Cells, 页码:2777-2781 , 文章类型: Article,,卷期:2008年26-11]
- Human embryonic stem cells (hESCs) are often cocultured on mitotically inactive fibroblast feeder cells to maintain their undifferentiated state. Under these growth conditions, hESCs form multilayered colonies of morphol...
- Notch Inhibition Promotes Human Embryonic Stem Cell-Derived Cardiac Mesoderm Differentiation
[作者:Jang, J; Ku, SY; Kim, JE; Choi, K; Kim, YY; Kim, HS; Oh, SK; Lee, EJ; Cho, HJ; Song, YH; Lee, SH; Lee, SH; Suh, CS; Kim, SH; Moon, SY; Choi, YM,期刊:Stem Cells, 页码:2782-2790 , 文章类型: Article,,卷期:2008年26-11]
- The roles of Notch signaling in cardiac differentiation from murine embryonic stem cells have been well documented. We investigated whether Notch signaling plays a similar role in human embryonic stem cells (hESCs). Alth...
- The Transcription Factor Zfp281 Controls Embryonic Stem Cell Pluripotency by Direct Activation and Repression of Target Genes
[作者:Wang, ZX; Teh, CHL; Chan, CMY; Chu, C; Rossbach, M; Kunarso, G; Allapitchay, TB; Wong, KY; Stanton, LW,期刊:Stem Cells, 页码:2791-2799 , 文章类型: Article,,卷期:2008年26-11]
- Oct4, Sox2, and Nanog are key components of a core transcriptional regulatory network that controls the ability of embryonic stem cells to differentiate into all cell types. Here we show that Zfp281, a zinc finger transc...
- Laminin-511 but Not-332,-111, or-411 Enables Mouse Embryonic Stem Cell Self-Renewal In Vitro
[作者:Domogatskaya, A; Rodin, S; Boutaud, A; Tryggvason, K,期刊:Stem Cells, 页码:2800-2809 , 文章类型: Article,,卷期:2008年26-11]
- We tested specific laminin (LN) isoforms for their ability to serve as substrata for maintaining mouse embryonic stem (ES) cells pluripotent in vitro in the absence of leukemia inhibitory factor or any other differentiat...
- Enhanced Reprogramming of Xist by Induced Upregulation of Tsix and Dnmt3a
[作者:Do, JT; Han, DW; Gentile, L; Sobek-Klocke, I; Stehling, M; Scholer, HR,期刊:Stem Cells, 页码:2821-2831 , 文章类型: Article,,卷期:2008年26-11]
- Reactivation of Oct4 gene expression occurs within 2 days of fusion of somatic cells with pluripotent stem cells and within 9 days of postinfection of four transcription factors. We sought to determine whether somatic ge...
- Soluble Flt-1 Regulates Flk-1 Activation to Control Hematopoietic and Endothelial Development in an Oxygen-Responsive Manner
[作者:Purpura, KA; George, SHL; Dang, SM; Choi, K; Nagy, A; Zandstra, PW,期刊:Stem Cells, 页码:2832-2842 , 文章类型: Article,,卷期:2008年26-11]
- Vascular endothelial growth factor (VEGF) and the vascular endothelial growth factor receptors (VEGFRs) regulate the development of hemogenic mesoderm. Oxygen concentration-mediated activation of hypoxia-inducible factor...
- Transformation by Retroviral Vectors of Bone Marrow-Derived Mesenchymal Cells Induces Mitochondria-Dependent cAMP-Sensitive Reactive Oxygen Species Production
[作者:Piccoli, C; Scrima, R; Ripoli, M; Di Ianni, M; Del Papa, B; D'Aprile, A; Quarato, G; Martelli, MP; Servillo, G; Ligas, C; Boffoli, D; Tabilio, A; Capitanioa, N,期刊:Stem Cells, 页码:2843-2854 , 文章类型: Article,,卷期:2008年26-11]
- Retroviral vectors are used in human gene therapy trials to stably introduce therapeutic genes in the genome of patients' cells. Their applicability, however, is frustrated by the limited viability of transformed cells a...
- Cyclic ADP-Ribose-Mediated Expansion and Stimulation of Human Mesenchymal Stem Cells by the Plant Hormone Abscisic Acid
[作者:Scarfi, S; Ferraris, C; Fruscione, F; Fresia, C; Guida, L; Bruzzone, S; Usai, C; Parodi, A; Millo, E; Salis, A; Burastero, G; De Flora, A; Zocchi, E,期刊:Stem Cells, 页码:2855-2864 , 文章类型: Article,,卷期:2008年26-11]
- Abscisic acid (ABA) is a phytohormone involved in fundamental processes in higher plants. Endogenous ABA biosynthesis occurs also in lower Metazoa, in which ABA regulates several physiological functions by activating ADP...
- Immune Properties of Human Umbilical Cord Wharton's Jelly-Derived Cells
[作者:Weiss, ML; Anderson, C; Medicetty, S; Seshareddy, KB; Weiss, RJ; Vanderwerff, I; Troyer, D; Mcintosh, KR,期刊:Stem Cells, 页码:2865-2874 , 文章类型: Article,,卷期:2008年26-11]
- Cells isolated from Wharton's jelly, referred to as umbilical cord matrix stromal (UCMS) cells, adhere to a tissue-culture plastic substrate, express mesenchymal stromal cell (MSC) surface markers, self-renew, and are mu...
- Differentiation of Neural Stem Cells into Oligodendrocytes: Involvement of the Polycomb Group Protein Ezh2
[作者:Sher, F; Rossler, R; Brouwer, N; Balasubramaniyan, V; Boddeke, E; Copray, S,期刊:Stem Cells, 页码:2875-2883 , 文章类型: Article,,卷期:2008年26-11]
- The mechanisms underlying the regulation of neural stem cell (NSC) renewal and maintenance of their multipotency are still not completely understood. Self-renewal of stem cells in general implies repression of genes that...
- Bone Marrow-Derived Mesenchymal Stromal Cells Express Cardiac-Specific Markers, Retain the Stromal Phenotype, and Do Not Become Functional Cardiomyocytes In Vitro
[作者:Rose, RA; Jiang, H; Wang, X; Helke, S; Tsoporis, JN; Gong, N; Keating, SCJ; Parker, TG; Backx, PH; Keating, A,期刊:Stem Cells, 页码:2884-2892 , 文章类型: Article,,卷期:2008年26-11]
- Although bone marrow-derived mesenchymal stromal cells (MSCs) may be beneficial in treating heart disease, their ability to transdifferentiate into functional cardiomyocytes remains unclear. Here, bone marrow-derived MSC...
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