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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共14条记录   A Transporter Converted into a Sensor, a Phototaxis Signaling Mutant of Bacteriorhodopsin at 3.0 angstrom [作者：Spudich, EN; Ozorowski, G; Schow, EV; Tobias, DJ; Spudich, JL; Luecke, H,期刊：Journal of Molecular Biology, 页码：455-463 , 文章类型： Article，,卷期：2012年415-3] Bacteriorhodopsin (BR) and sensory rhodopsin II (SRII), homologous photoactive proteins in haloarchaea, have different molecular functions. BR is a light-driven proton pump, whereas SRII is a phototaxis receptor that tra... Facilitated Assembly of the Preinitiation Complex by Separated Tail and Head/Middle Modules of the Mediator [作者：Galdieri, L; Desai, P; Vancura, A,期刊：Journal of Molecular Biology, 页码：464-474 , 文章类型： Article，,卷期：2012年415-3] Mediator is a general coactivator of RNA polymerase II (RNA pol II) bridging enhancer-bound transcriptional factors with RNA pol II. Mediator is organized in three distinct subcomplexes: head, middle, and tail modules. T... Differential Reaction Kinetics, Cleavage Complex Formation, and Nonamer Binding Domain Dependence Dictate the Structure-Specific and Sequence-Specific Nuclease Activity of RAGs [作者：Naik, AK; Raghavan, SC,期刊：Journal of Molecular Biology, 页码：475-488 , 文章类型： Article，,卷期：2012年415-3] During V(D)J recombination, RAG (recombination-activating gene) complex cleaves DNA based on sequence specificity. Besides its physiological function, RAG has been shown to act as a structure-specific nuclease. Recently,... The Structure of Aquifex aeolicus Ribosomal Protein S8 Reveals a Unique Subdomain that Contributes to an Extremely Tight Association with 16S rRNA [作者：Menichelli, E; Edgcomb, SP; Recht, MI; Williamson, JR,期刊：Journal of Molecular Biology, 页码：489-502 , 文章类型： Article，,卷期：2012年415-3] The assembly of ribonucleoprotein complexes occurs under a broad range of conditions, but the principles that promote assembly and allow function at high temperature are poorly understood. The ribosomal protein S8 from A... Structure and Kinetic Stability of the p63 Tetramerization Domain [作者：Natan, E; Joerger, AC,期刊：Journal of Molecular Biology, 页码：503-513 , 文章类型： Article，,卷期：2012年415-3] The p53 family of transcription factors-comprising p53, p63 and p73- plays an important role in tumor prevention and development. Essential to their function is the formation of tetramers, allowing cooperative binding to... Structural Studies of Intermediates along the Cyclization Pathway of Aplysia ADP-Ribosyl Cyclase [作者：Kotaka, M; Graeff, R; Chen, Z; Zhang, LH; Lee, HC; Hao, Q,期刊：Journal of Molecular Biology, 页码：514-526 , 文章类型： Article，,卷期：2012年415-3] Cyclic ADP-ribose (cADPR) is a calcium messenger that can mobilize intracellular Ca2+ stores and activate Ca2+ influx to regulate a wide range of physiological processes. Aplysia cyclase is the first member of the ADP-ri... Crystal Structure of Human Mitochondrial PheRS Complexed with tRNA(Phe) in the Active "Open" State [作者：Klipcan, L; Moor, N; Finarov, I; Kessler, N; Sukhanova, M; Safro, MG,期刊：Journal of Molecular Biology, 页码：527-537 , 文章类型： Article，,卷期：2012年415-3] Monomeric human mitochondrial phenylalanyl-tRNA synthetase (PheRS), or hmPheRS, is the smallest known enzyme exhibiting aminoacylation activity. HmPheRS consists of only two structural domains and differs markedly from h... Salt Bridges Regulate Both Dimer Formation and Monomeric Flexibility in HdeB and May Have a Role in Periplasmic Chaperone Function [作者：Wang, WJ; Rasmussen, T; Harding, AJ; Booth, NA; Booth, IR; Naismith, JH,期刊：Journal of Molecular Biology, 页码：538-546 , 文章类型： Article，,卷期：2012年415-3] Escherichia coli and Gram-negative bacteria that live in the human gut must be able to tolerate rapid and large changes in environmental pH. Low pH irreversibly denatures and precipitates many bacterial proteins. While c... The Structure and Enzymatic Properties of a Novel RNase II Family Enzyme from Deinococcus radiodurans [作者：Schmier, BJ; Seetharaman, J; Deutscher, MP; Hunt, JF; Malhotra, A,期刊：Journal of Molecular Biology, 页码：547-559 , 文章类型： Article，,卷期：2012年415-3] Exoribonucleases are vital in nearly all aspects of RNA metabolism, including RNA maturation, end-turnover, and degradation. RNase II and RNase R are paralogous members of the RNR superfamily of nonspecific, 3' -> 5', pr... Crystal Structures of Two Solute Receptors for L-Cystine and L-Cysteine, Respectively, of the Human Pathogen Neisseria gonorrhoeae [作者：Bulut, H; Moniot, S; Licht, A; Scheffel, F; Gathmann, S; Saenger, W; Schneider, E,期刊：Journal of Molecular Biology, 页码：560-572 , 文章类型： Article，,卷期：2012年415-3] ATP-binding cassette (ABC) transporters are integral membrane proteins that carry a variety of substrates across biological membranes at the expense of ATP. The here considered prokaryotic canonical importers consist of ... Inhibition of Pseudomonas aeruginosa Virulence: Characterization of the AprA-AprI Interface and Species Selectivity [作者：Bardoel, BW; van Kessel, KPM; van Strijp, JAG; Milder, FJ,期刊：Journal of Molecular Biology, 页码：573-583 , 文章类型： Article，,卷期：2012年415-3] Pseudomonas aeruginosa secretes the virulence factor alkaline protease (AprA) to enhance its survival. AprA cleaves one of the key microbial recognition molecules, monomeric flagellin, and thereby diminishes Toll-like re... Amyloid Fibrils Formed by the Programmed Cell Death Regulator Bcl-xL [作者：Chenal, A; Vendrely, C; Vitrac, H; Karst, JC; Gonneaud, A; Blanchet, CE; Pichard, S; Garcia, E; Salin, B; Catty, P; Gillet, D; Hussy, N; Marquette, C; Almunia, C; Forge, V,期刊：Journal of Molecular Biology, 页码：584-599 , 文章类型： Article，,卷期：2012年415-3] The accumulation of amyloid fibers due to protein misfolding is associated with numerous human diseases. For example, the formation of amyloid deposits in neurodegenerative pathologies is correlated with abnormal apoptos... The H2A-H2B Dimeric Kinetic Intermediate Is Stabilized by Widespread Hydrophobic Burial with Few Fully Native Interactions [作者：Guyett, PJ; Gloss, LM,期刊：Journal of Molecular Biology, 页码：600-614 , 文章类型： Article，,卷期：2012年415-3] The H2A-H2B histone heterodimer folds via monomeric and dimeric kinetic intermediates. Within similar to 5 ms, the H2A and H2B polypeptides associate in a nearly diffusion limited reaction to form a dimeric ensemble, den... Structural Analyses of Covalent Enzyme-Substrate Analog Complexes Reveal Strengths and Limitations of De Novo Enzyme Design [作者：Wang, L; Althoff, EA; Bolduc, J; Jiang, L; Moody, J; Lassila, JK; Giger, L; Hilvert, D; Stoddard, B; Baker, D,期刊：Journal of Molecular Biology, 页码：615-625 , 文章类型： Article，,卷期：2012年415-3] We report the cocrystal structures of a computationally designed and experimentally optimized retro-aldol enzyme with covalently bound substrate analogs. The structure with a covalently bound mechanism-based inhibitor is...