- Human DNA Polymerase eta Is Pre-Aligned for dNTP Binding and Catalysis
[作者：Ummat, A; Silverstein, TD; Jain, R; Buku, A; Johnson, RE; Prakash, L; Prakash, S; Aggarwal, AK,期刊：Journal of Molecular Biology, 页码：627-634 , 文章类型： Article，,卷期：2012年415-4]
- Pre-steady-state kinetic studies on Y-family DNA polymerase eta (Pol eta) have suggested that the polymerase undergoes a rate-limiting conformational change step before the phosphoryl transfer of the incoming nucleotide ...
- Crystal Structure of Sol i 2: A Major Allergen from Fire Ant Venom
[作者：Borer, AS; Wassmann, P; Schmidt, M; Hoffman, DR; Zhou, JJ; Wright, C; Schirmer, T; Markovic-Housley, Z,期刊：Journal of Molecular Biology, 页码：635-648 , 文章类型： Article，,卷期：2012年415-4]
- Sol i 2 is a potent allergen from the venom of red imported fire ant, which contains allergens Sol i 1, Sol i 2, Sol i 3, and Sol i 4 that are known to be powerful triggers of anaphylaxis. Sol i 2 causes IgE antibody pro...
- The Structure of the NXF2/NXT1 Heterodimeric Complex Reveals the Combined Specificity and Versatility of the NTF2-Like Fold
[作者：Kerkow, DE; Carmel, AB; Menichelli, E; Ambrus, G; Hills, RD; Gerace, L; Williamson, JR,期刊：Journal of Molecular Biology, 页码：649-665 , 文章类型： Article，,卷期：2012年415-4]
- NXF1-like members of the NXF (nuclear export factor) family orchestrate bulk nuclear export of mRNA, while functionally distinct NXF variant proteins carry out separate substrate-specific and tissue-specific RNA regulati...
- A Conserved Glu-Arg Salt Bridge Connects Coevolved Motifs That Define the Eukaryotic Protein Kinase Fold
[作者：Yang, J; Wu, J; Steichen, JM; Kornev, AP; Deal, MS; Li, S; Sankaran, B; Woods, VL; Taylor, SS,期刊：Journal of Molecular Biology, 页码：666-679 , 文章类型： Article，,卷期：2012年415-4]
- Eukaryotic protein kinases (EPKs) feature two coevolved structural segments, the Activation segment, which starts with the Asp-Phe-Gly (DFG) and ends with the Ala-Pro-Glu (APE) motifs, and the helical GHE subdomain that ...
- Solution Structure of the HIV-1 Exon Splicing Silencer 3
[作者：Levengood, JD; Rollins, C; Mishler, CHJ; Johnson, CA; Miner, G; Rajan, P; Znosko, BM; Tolbert, BS,期刊：Journal of Molecular Biology, 页码：680-698 , 文章类型： Article，,卷期：2012年415-4]
- Alternative splicing of the human immunodeficiency virus type 1 (HIV-1) genomic RNA is necessary to produce the complete viral protein complement, and aberrations in the splicing pattern impair HIV-1 replication. Genome ...
- A Reverse Binding Motif That Contributes to Specific Protease Inhibition by Antibodies
[作者：Schneider, EL; Lee, MS; Baharuddin, A; Goetz, DH; Farady, CJ; Ward, M; Wang, CI; Craik, CS,期刊：Journal of Molecular Biology, 页码：699-715 , 文章类型： Article，,卷期：2012年415-4]
- The type II transmembrane serine protease family consists of 18 closely related serine proteases that are implicated in multiple functions. To identify selective, inhibitory antibodies against one particular type II tran...
- Analysis of the Active-Site Mechanism of Tyrosyl-DNA Phosphodiesterase I: A Member of the Phospholipase D Superfamily
[作者：Gajewski, S; Comeaux, EQ; Jafari, N; Bharatham, N; Bashford, D; White, SW; van Waardenburg, RCAM,期刊：Journal of Molecular Biology, 页码：741-758 , 文章类型： Article，,卷期：2012年415-4]
- Tyrosyl-DNA phosphodiesterase I (Tdp1) is a member of the phospholipase D superfamily that hydrolyzes 3'-phospho-DNA adducts via two conserved catalytic histidines-one acting as the lead nucleophile and the second acting...
- The Receptor-CheW Binding Interface in Bacterial Chemotaxis
[作者：Vu, A; Wang, XQ; Zhou, HJ; Dahlquist, FW,期刊：Journal of Molecular Biology, 页码：759-767 , 文章类型： Article，,卷期：2012年415-4]
- The basic structural unit of the signaling complex in bacterial chemotaxis consists of the chemotaxis kinase CheA, the coupling protein CheW, and chemoreceptors. These complexes play an important role in regulating the k...
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