- (R)-(5-tert-Butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)-urea (ABT-102) blocks polymodal activation of transient receptor potential vanilloid 1 receptors in vitro and heat-evoked firing of spinal dorsal horn neurons in vivo
[作者:Surowy, CS; Neelands, TR; Bianchi, BR; McGaraughty, S; El Kouhen, R; Han, P; Chu, KL; McDonald, HA; Vos, M; Niforatos, W; Bayburt, EK; Gomtsyan, A; Lee, CH; Honore, P; Sullivan, JP; Jarvis, MF; Faltynek, CR,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:879-888 , 文章类型: Article,,卷期:2008年326-3]
The transient receptor potential vanilloid (TRPV) 1 receptor, a nonselective cation channel expressed on peripheral sensory neurons and in the central nervous system, plays a key role in pain. TRPV1 receptor antagonis...
- Methanandamide allosterically inhibits in vivo the function of peripheral nicotinic acetylcholine receptors containing the alpha 7-subunit
[作者:Baranowska, U; Gothert, M; Rudz, R; Malinowska, B,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:912-919 , 文章类型: Article,,卷期:2008年326-3]
Methanandamide ( MAEA), the stable analog of the endocannabinoid anandamide, has been proven in Xenopus oocytes to allosterically inhibit the function of the alpha 7-nicotinic acetylcholine receptors (nAChRs) in a can...
- Phosphodiesterase isozymes involved in regulation of HCO3- secretion in isolated mouse stomach in vitro
[作者:Kita, K; Takahashi, K; Ohashi, Y; Takasuka, H; Aihara, E; Takeuchi, K,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:889-896 , 文章类型: Article,,卷期:2008年326-3]
(+/-)-(E)-4-Ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide] (NOR-3), a nitric-oxide (NO) donor, is known to increase HCO3- secretion in rat stomachs, intracellularly mediated by cGMP; yet, there is no information abo...
- Proinflammatory effect of sodium 4-phenylbutyrate in Delta F508Cystic fibrosis transmembrane conductance regulator lung epithelial cells: Involvement of extracellular signal-regulated protein kinase 1/2 and c-Jun-NH2-Terminal kinase signaling
[作者:Roque, T; Boncoeur, E; Saint-Criq, V; Bonvin, E; Clement, A; Tabary, O; Jacquot, J,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:949-956 , 文章类型: Article,,卷期:2008年326-3]
- Isoflavone attenuates vascular contraction through inhibition of the RhoA/Rho-kinase signaling pathway
[作者:Seok, YM; Baek, I; Kim, YH; Jeong, YS; Lee, IJ; Shin, DH; Hwang, YH; Kim, IK,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:991-998 , 文章类型: Article,,卷期:2008年326-3]
Isoflavones decrease blood pressure, improve lipid profiles, and restore vascular function. We hypothesized that isoflavone attenuates vascular contraction by inhibiting RhoA/ Rho-kinase signaling pathway. Rat aortic ...
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