- Semaphorin 3E, an exception to the rule
[作者：Klagsbrun, M; Shimizu, A,期刊：Journal of clinical investigation, 页码：2658-2660 , 文章类型： Editorial Material，,卷期：2010年120-8]
- Class 3 semaphorins (Sema3s) regulate axon guidance, angiogenesis, tumor growth, and tumor metastasis. Neuropilins (NRPs; NRP1 and NRP2) are the cell surface receptors for the Sema3s. However, to signal, interaction of S...
- Axon initial segment dysfunction in a mouse model of genetic epilepsy with febrile seizures plus
[作者：Wimmer, VC; Reid, CA; Mitchell, S; Richards, KL; Scaf, BB; Leaw, BT; Hill, EL; Royeck, M; Horstmann, MT; Cromer, BA; Davies, PJ; Xu, R; Lerche, H; Berkovic, SF; Beck, H; Petrou, S,期刊：Journal of clinical investigation, 页码：2661-2671 , 文章类型： Article，,卷期：2010年120-8]
- Febrile seizures are a common childhood seizure disorder and a defining feature of genetic epilepsy with febrile seizures plus (GEFS+), a syndrome frequently associated with Na+ channel mutations. Here, we describe the c...
- Dynamic distribution of muscle-specific calpain in mice has a key role in physical-stress adaptation and is impaired in muscular dystrophy
[作者：Ojima, K; Kawabata, Y; Nakao, H; Nakao, K; Doi, N; Kitamura, F; Ono, Y; Hata, S; Suzuki, H; Kawahara, H; Bogomolovas, J; Witt, C; Ottenheijm, C; Labeit, S; Granzier, H; Toyama-Sorimachi, N; Sorimachi, M; Suzuki, K; Maeda, T; Abe, K; Aiba, A; Sorimachi, H,期刊：Journal of clinical investigation, 页码：2672-2683 , 文章类型： Article，,卷期：2010年120-8]
- Limb-girdle muscular dystrophy type 2A (LGMD2A) is a genetic disease that is caused by mutations in the calpain 3 gene (CAPN3), which encodes the skeletal muscle-specific calpain, calpain 3 (also known as p94). However, ...
- Sema3E-Plexin D1 signaling drives human cancer cell invasiveness and metastatic spreading in mice
[作者：Casazza, A; Finisguerra, V; Capparuccia, L; Camperi, A; Swiercz, JM; Rizzolio, S; Rolny, C; Christensen, C; Bertotti, A; Sarotto, I; Risio, M; Trusolino, L; Weitz, J; Schneider, M; Mazzone, M; Comoglio, PM; Tamagnone, L,期刊：Journal of clinical investigation, 页码：2684-2698 , 文章类型： Article，,卷期：2010年120-8]
- Semaphorin 3E (Sema3E) is a secreted molecule implicated in axonal path finding and inhibition of developmental and postischentic angiogenesis. Sema3E is also highly expressed in metastatic cancer cells, but its mechanis...
- Hypoxia-inducible factor 2 alpha regulates macrophage function in mouse models of acute and tumor inflammation
[作者：Imtiyaz, HZ; Williams, EP; Hickey, MM; Patel, SA; Durham, AC; Yuan, LJ; Hammond, R; Gimotty, PA; Keith, B; Simon, MC,期刊：Journal of clinical investigation, 页码：2699-2714 , 文章类型： Article，,卷期：2010年120-8]
- Hypoxia-inducible factor 1 alpha (HIF-1 alpha) and HIF-2 alpha display unique and sometimes opposing activities in regulating cellular energy homeostasis, cell fate decisions, and oncogenesis. Macrophages exposed to hypo...
- Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant
[作者：Sun, SH; Sprenger, CCT; Vessella, RL; Haugk, K; Soriano, K; Mostaghel, EA; Page, ST; Coleman, IM; Nguyen, HM; Sun, HY; Nelson, PS; Plymate, SR,期刊：Journal of clinical investigation, 页码：2715-2730 , 文章类型： Article，,卷期：2010年120-8]
- Progression of prostate cancer following castration is associated with increased androgen receptor (AR) expression and signaling despite AR blockade. Recent studies suggest that these activities are due to the generation...
- Ectodomain shedding of EGFR ligands and TNFR1 dictates hepatocyte apoptosis during fulminant hepatitis in mice
[作者：Murthy, A; Defamie, V; Smookler, DS; Di Grappa, MA; Horiuchi, K; Federici, M; Sibilia, M; Blobel, CP; Khokha, R,期刊：Journal of clinical investigation, 页码：2731-2744 , 文章类型： Article，,卷期：2010年120-8]
- The cell death receptor Fas plays a role in the establishment of fulminant hepatitis, a major cause of drug-induced liver failure. Fas activation elicits extrinsic apoptotic and hepatoprotective signals; however, the mec...
- Cholinergic mesencephalic neurons are involved in gait and postural disorders in Parkinson disease
[作者：Karachi, C; Grabli, D; Bernard, FA; Tande, D; Wattiez, N; Belaid, H; Bardinet, E; Prigent, A; Nothacker, HP; Hunot, S; Hartmann, A; Lehericy, S; Hirsch, EC; Francois, C,期刊：Journal of clinical investigation, 页码：2745-2754 , 文章类型： Article，,卷期：2010年120-8]
- Gait disorders and postural instability, which are commonly observed in elderly patients with Parkinson disease (PD), respond poorly to dopaminergic agents used to treat other parkinsonian symptoms. The brain structures ...
- Activating transcription factor 4 regulates osteoclast differentiation in mice
[作者：Cao, HL; Yu, SB; Yao, Z; Galson, DL; Jiang, Y; Zhang, XY; Fan, J; Lu, BF; Guan, YF; Luo, M; Lai, YM; Zhu, YB; Kurihara, N; Patrene, K; Roodman, GD; Xiao, GZ,期刊：Journal of clinical investigation, 页码：2755-2766 , 文章类型： Article，,卷期：2010年120-8]
- Activating transcription factor 4 (ATF4) is a critical transcription factor for osteoblast (OBL) function and bone formation; however, a direct role in osteoclasts (OCLs) has not been established. Here, we targeted expre...
- Antagonism of TIM-1 blocks the development of disease in a humanized mouse model of allergic asthma
[作者：Sonar, SS; Hsu, YM; Conrad, ML; Majeau, GR; Kilic, A; Garber, E; Gao, Y; Nwankwo, C; Willer, G; Dudda, JC; Kim, H; Bailly, V; Pagenstecher, A; Rennert, PD; Renz, H,期刊：Journal of clinical investigation, 页码：2767-2781 , 文章类型： Article，,卷期：2010年120-8]
- Studies in mice and humans have revealed that the T cell, immunoglobulin, mucin (TIM) genes are associated with several atopic diseases. TIM-1 is a type I membrane protein that is expressed on T cells upon stimulation an...
- Angiotensin II sustains brain inflammation in mice via TGF-beta
[作者：Lanz, TV; Ding, ZQ; Ho, PP; Luo, JA; Agrawal, AN; Srinagesh, H; Axtell, R; Zhang, H; Platten, M; Wyss-Coray, T; Steinman, L,期刊：Journal of clinical investigation, 页码：2782-2794 , 文章类型： Article，,卷期：2010年120-8]
- The renin-angiotensin-aldosterone system (RAAS) is a key hormonal system regulating blood pressure. However, expression of RAAS components has recently been detected in immune cells, and the RAAS has been implicated in s...
- CCM3 signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations
[作者：Zheng, XJ; Xu, C; Di Lorenzo, A; Kleaveland, B; Zou, ZY; Seiler, C; Chen, M; Cheng, L; Xiao, JP; He, J; Pack, MA; Sessa, WC; Kahn, ML,期刊：Journal of clinical investigation, 页码：2795-2804 , 文章类型： Article，,卷期：2010年120-8]
- Cerebral cavernous malformation is a common human vascular disease that arises due to loss-of-function mutations in genes encoding three intracellular adaptor proteins, cerebral cavernous malformations 1 protein (CCM1), ...
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