- Haploid Genetic Screens in Human Cells Identify Host Factors Used by Pathogens
[作者:Carette, JE; Guimaraes, CP; Varadarajan, M; Park, AS; Wuethrich, I; Godarova, A; Kotecki, M; Cochran, BH; Spooner, E; Ploegh, HL; Brummelkamp, TR,期刊:Science, 页码:1231-1235 , 文章类型: Article,,卷期:2009年326-5957]
- Loss-of-function genetic screens in model organisms have elucidated numerous biological processes, but the diploid genome of mammalian cells has precluded large-scale gene disruption. We used insertional mutagenesis to d...
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