- Thioredoxin Regulates Multiple Hydrogen Peroxide-Induced Signaling Pathways in Candida albicans
[作者:Dantas, AD; Patterson, MJ; Smith, DA; MacCallum, DM; Erwig, LP; Morgan, BA; Quinn, J,期刊:Molecular and Cellular Biology, 页码:4550-4563 , 文章类型: Article,,卷期:2010年30-19]
- The ability of the major systemic fungal pathogen of humans, Candida albicans, to sense and respond to reactive oxygen species (ROS), such as H2O2 generated by the host immune system, is required for survival in the host...
- The Type I Interferon Signaling Pathway Is a Target for Glucocorticoid Inhibition
[作者:Flammer, JR; Dobrovolna, J; Kennedy, MA; Chinenov, Y; Glass, CK; Ivashkiv, LB; Rogatsky, I,期刊:Molecular and Cellular Biology, 页码:4564-4574 , 文章类型: Article,,卷期:2010年30-19]
- Type I interferon (IFN) is essential for host defenses against viruses; however, dysregulated IFN signaling is causally linked to autoimmunity, particularly systemic lupus erythematosus. Autoimmune disease treatments rel...
- Interferon Consensus Sequence Binding Protein (ICSBP) Decreases beta-Catenin Activity in Myeloid Cells by Repressing GAS2 Transcription
[作者:Huang, WQ; Zhou, W; Saberwal, G; Konieczna, I; Horvath, E; Katsoulidis, E; Platanias, LC; Eklund, EA,期刊:Molecular and Cellular Biology, 页码:4575-4594 , 文章类型: Article,,卷期:2010年30-19]
- The interferon consensus sequence binding protein (ICSBP) is an interferon regulatory transcription factor, also referred to as IRF8. ICSBP acts as a suppressor of myeloid leukemia, although few target genes explaining t...
- Renal Oxygenation Suppresses VHL Loss-Induced Senescence That Is Caused by Increased Sensitivity to Oxidative Stress
[作者:Welford, SM; Dorie, MJ; Li, XF; Haase, VH; Giaccia, AJ,期刊:Molecular and Cellular Biology, 页码:4595-4603 , 文章类型: Article,,卷期:2010年30-19]
- Loss of the VHL tumor suppressor is regarded as an initiating event in the development of clear-cell renal carcinoma. Surprisingly, loss of VHL induces senescence in mouse fibroblasts in vitro, a response that would rest...
- mDia1 Targets v-Src to the Cell Periphery and Facilitates Cell Transformation, Tumorigenesis, and Invasion
[作者:Tanji, M; Ishizaki, T; Ebrahimi, S; Tsuboguchi, Y; Sukezane, T; Akagi, T; Frame, MC; Hashimoto, N; Miyamoto, S; Narumiya, S,期刊:Molecular and Cellular Biology, 页码:4604-4615 , 文章类型: Article,,卷期:2010年30-19]
- The small GTPase Rho regulates cell morphogenesis through remodeling of the actin cytoskeleton. While Rho is overexpressed in many clinical cancers, the role of Rho signaling in oncogenesis remains unknown. mDia1 is a Rh...
- Requirement of JIP1-Mediated c-Jun N-Terminal Kinase Activation for Obesity-Induced Insulin Resistance
[作者:Morel, C; Standen, CL; Jung, DY; Gray, S; Ong, H; Flavell, RA; Kim, JK; Davis, RJ,期刊:Molecular and Cellular Biology, 页码:4616-4625 , 文章类型: Article,,卷期:2010年30-19]
- The c-Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) has been proposed to act as a scaffold protein that mediates JNK activation. However, recent studies have implicated JIP1 in multiple biochemical processes...
- Distinct Subregions of Swi1 Manifest Striking Differences in Prion Transmission and SWI/SNF Function
[作者:Du, ZQ; Crow, ET; Kang, HS; Li, LM,期刊:Molecular and Cellular Biology, 页码:4644-4655 , 文章类型: Article,,卷期:2010年30-19]
- We have recently reported that the yeast chromatin-remodeling factor Swi1 can exist as a prion, [SWI+], demonstrating a link between prionogenesis and global transcriptional regulation. To shed light on how the Swi1 conf...
- MeCP2 Binds Cooperatively to Its Substrate and Competes with Histone H1 for Chromatin Binding Sites
[作者:Ghosh, RP; Horowitz-Scherer, RA; Nikitina, T; Shlyakhtenko, LS; Woodcock, CL,期刊:Molecular and Cellular Biology, 页码:4656-4670 , 文章类型: Article,,卷期:2010年30-19]
- Sporadic mutations in the hMeCP2 gene, coding for a protein that preferentially binds symmetrically methylated CpGs, result in the severe neurological disorder Rett syndrome (RTT). In the present work, employing a wide r...
- The RNA Recognition Motif of Eukaryotic Translation Initiation Factor 3g (eIF3g) Is Required for Resumption of Scanning of Posttermination Ribosomes for Reinitiation on GCN4 and Together with eIF3i Stimulates Linear Scanning
[作者:Cuchalova, L; Kouba, T; Herrmannova, A; Danyi, I; Chiu, WL; Valasek, L,期刊:Molecular and Cellular Biology, 页码:4671-4686 , 文章类型: Article,,卷期:2010年30-19]
- Recent reports have begun unraveling the details of various roles of individual eukaryotic translation initiation factor 3 (eIF3) subunits in translation initiation. Here we describe functional characterization of two es...
- Impaired Binding of 14-3-3 to C-RAF in Noonan Syndrome Suggests New Approaches in Diseases with Increased Ras Signaling
[作者:Molzan, M; Schumacher, B; Ottmann, C; Baljuls, A; Polzien, L; Weyand, M; Thiel, P; Rose, R; Rose, M; Kuhenne, P; Kaiser, M; Rapp, UR; Kuhlmann, J; Ottmann, C,期刊:Molecular and Cellular Biology, 页码:4698-4711 , 文章类型: Article,,卷期:2010年30-19]
- The Ras-RAF-mitogen-activated protein kinase (Ras-RAF-MAPK) pathway is overactive in many cancers and in some developmental disorders. In one of those disorders, namely, Noonan syndrome, nine activating C-RAF mutations c...
- Myeloid Deletion of SIRT1 Induces Inflammatory Signaling in Response to Environmental Stress
[作者:Schug, TT; Xu, Q; Gao, HM; Peres-da-Silva, A; Draper, DW; Fessler, MB; Purushotham, A; Li, XL,期刊:Molecular and Cellular Biology, 页码:4712-4721 , 文章类型: Article,,卷期:2010年30-19]
- Macrophage activation and infiltration into resident tissues is known to mediate local inflammation and is a hallmark feature of metabolic syndrome. Members of the sirtuin family of proteins regulate numerous physiologic...
- BRCT Domain Interactions with Phospho-Histone H2A Target Crb2 to Chromatin at Double-Strand Breaks and Maintain the DNA Damage Checkpoint
[作者:Sofueva, S; Du, LL; Limbo, O; Williams, JS; Russell, P,期刊:Molecular and Cellular Biology, 页码:4732-4743 , 文章类型: Article,,卷期:2010年30-19]
- Relocalization of checkpoint proteins to chromatin flanking DNA double-strand breaks (DSBs) is critical for cellular responses to DNA damage. Schizosaccharomyces pombe Crb2, which mediates Chk1 activation by Rad3(ATR), f...
- Drosophila MCRS2 Associates with RNA Polymerase II Complexes To Regulate Transcription
[作者:Andersen, DS; Raja, SJ; Colombani, J; Shaw, RL; Langton, PF; Akhtar, A; Tapon, N,期刊:Molecular and Cellular Biology, 页码:4744-4755 , 文章类型: Article,,卷期:2010年30-19]
- Drosophila MCRS2 (dMCRS2; MCRS2/MSP58 and its splice variant MCRS1/p78 in humans) belongs to a family of forkhead-associated (FHA) domain proteins. Whereas human MCRS2 proteins have been associated with a variety of cell...
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