- The beta/Gcd7 Subunit of Eukaryotic Translation Initiation Factor 2B (eIF2B), a Guanine Nucleotide Exchange Factor, Is Crucial for Binding eIF2 In Vivo
[作者:Dev, K; Qiu, HF; Dong, JS; Zhang, F; Barthlme, D; Hinnebusch, AG,期刊:Molecular and Cellular Biology, 页码:5218-5233 , 文章类型: Article,,卷期:2010年30-21]
- Eukaryotic translation initiation factor 2B (eIF2B) is the guanine nucleotide exchange factor (GEF) for eukaryotic translation initiation factor 2, which stimulates formation of the eIF2-GTP-Met-tRNA(i)(Met) ternary comp...
- Drosophila Transcription Factor Tramtrack69 Binds MEP1 To Recruit the Chromatin Remodeler NuRD
[作者:Reddy, BA; Bajpe, PK; Bassett, A; Moshkin, YM; Kozhevnikova, E; Bezstarosti, K; Demmers, JAA; Travers, AA; Verrijzer, CP,期刊:Molecular and Cellular Biology, 页码:5234-5244 , 文章类型: Article,,卷期:2010年30-21]
- ATP-dependent chromatin-remodeling complexes (remodelers) are essential regulators of chromatin structure and gene transcription. How remodelers can act in a gene-selective manner has remained enigmatic. A yeast two-hybr...
- Protein Arginine Methylation Facilitates Cotranscriptional Recruitment of Pre-mRNA Splicing Factors
[作者:Chen, YC; Milliman, EJ; Goulet, I; Cote, J; Jackson, CA; Vollbracht, JA; Yu, MC,期刊:Molecular and Cellular Biology, 页码:5245-5256 , 文章类型: Article,,卷期:2010年30-21]
- Cotranscriptional recruitment of pre-mRNA splicing factors to their genomic targets facilitates efficient and ordered assembly of a mature messenger ribonucleoprotein particle (mRNP). However, how the cotranscriptional r...
- Doubles Game: Src-Stat3 versus p53-PTEN in Cellular Migration and Invasion
[作者:Mukhopadhyay, UK; Mooney, P; Jia, L; Eves, R; Raptis, L; Mak, AS,期刊:Molecular and Cellular Biology, 页码:4980-4995 , 文章类型: Article,,卷期:2010年30-21]
- We have recently shown that Src induces the formation of podosomes and cell invasion by suppressing endogenous p53, while enhanced p53 strongly represses the Src-induced invasive phenotype. However, the mechanism by whic...
- Insulin Regulates Adipocyte Lipolysis via an Akt-Independent Signaling Pathway
[作者:Choi, SM; Tucker, DF; Gross, DN; Easton, RM; DiPilato, LM; Dean, AS; Monks, BR; Birnbaum, MJ,期刊:Molecular and Cellular Biology, 页码:5009-5020 , 文章类型: Article,,卷期:2010年30-21]
- After a meal, insulin suppresses lipolysis through the activation of its downstream kinase, Akt, resulting in the inhibition of protein kinase A (PKA), the main positive effector of lipolysis. During insulin resistance, ...
- Polyamines Regulate the Stability of JunD mRNA by Modulating the Competitive Binding of Its 3 ' Untranslated Region to HuR and AUF1
[作者:Zou, TT; Rao, JN; Liu, L; Xiao, L; Yu, TX; Jiang, P; Gorospe, M; Wang, JY,期刊:Molecular and Cellular Biology, 页码:5021-5032 , 文章类型: Article,,卷期:2010年30-21]
- Polyamines critically regulate all mammalian cell growth and proliferation by mechanisms such as the repression of growth-inhibitory proteins, including JunD. Decreasing the levels of cellular polyamines stabilizes JunD ...
- Loss of Par-1a/MARK3/C-TAK1 Kinase Leads to Reduced Adiposity, Resistance to Hepatic Steatosis, and Defective Gluconeogenesis
[作者:Lennerz, JK; Hurov, JB; White, LS; Lewandowski, KT; Prior, JL; Planer, GJ; Gereau, RW; Piwnica-Worms, D; Schmidt, RE; Piwnica-Worms, H,期刊:Molecular and Cellular Biology, 页码:5043-5056 , 文章类型: Article,,卷期:2010年30-21]
- Par-1 is an evolutionarily conserved protein kinase required for polarity in worms, flies, frogs, and mammals. The mammalian Par-1 family consists of four members. Knockout studies of mice implicate Par-1b/MARK2/EMK in r...
- Cortactin Modulates RhoA Activation and Expression of Cip/Kip Cyclin-Dependent Kinase Inhibitors To Promote Cell Cycle Progression in 11q13-Amplified Head and Neck Squamous Cell Carcinoma Cells
[作者:Croucher, DR; Rickwood, D; Tactacan, CM; Musgrove, EA; Daly, RJ,期刊:Molecular and Cellular Biology, 页码:5057-5070 , 文章类型: Article,,卷期:2010年30-21]
- The cortactin oncoprotein is frequently overexpressed in head and neck squamous cell carcinoma (HNSCC), often due to amplification of the encoding gene (CTTN). While cortactin overexpression enhances invasive potential, ...
- The Ubiquitin Carboxyl Hydrolase BAP1 Forms a Ternary Complex with YY1 and HCF-1 and Is a Critical Regulator of Gene Expression
[作者:Yu, H; Mashtalir, N; Daou, S; Hammond-Martel, I; Ross, J; Sui, GC; Hart, GW; Rauscher, FJ; Drobetsky, E; Milot, E; Shi, Y; Affar, EB,期刊:Molecular and Cellular Biology, 页码:5071-5085 , 文章类型: Article,,卷期:2010年30-21]
- The candidate tumor suppressor BAP1 is a deubiquitinating enzyme (DUB) involved in the regulation of cell proliferation, although the molecular mechanisms governing its function remain poorly defined. BAP1 was recently s...
- Protein Kinase C delta-Mediated Phosphorylation of Phospholipase D Controls Integrin-Mediated Cell Spreading
[作者:Chae, YC; Kim, KL; Ha, SH; Kim, J; Suh, PG; Ryu, SH,期刊:Molecular and Cellular Biology, 页码:5086-5098 , 文章类型: Article,,卷期:2010年30-21]
- Integrin signaling plays critical roles in cell adhesion, spreading, and migration, and it is generally accepted that to regulate these integrin functions accurately, localized actin remodeling is required. However, the ...
- Inhibition of Human Peptide Deformylase Disrupts Mitochondrial Function
[作者:Escobar-Alvarez, S; Gardner, J; Sheth, A; Manfredi, G; Yang, GL; Ouerfelli, O; Heaney, ML; Scheinberg, DA,期刊:Molecular and Cellular Biology, 页码:5099-5109 , 文章类型: Article,,卷期:2010年30-21]
- Deformylases are metalloproteases in bacteria, plants, and humans that remove the N-formyl-methionine off peptides in vitro. The human homolog of peptide deformylase (HsPDF) resides in the mitochondria, along with its pu...
- Chromatin Remodeling around Nucleosome-Free Regions Leads to Repression of Noncoding RNA Transcription
[作者:Yadon, AN; Van de Mark, D; Basom, R; Delrow, J; Whitehouse, I; Tsukiyama, T,期刊:Molecular and Cellular Biology, 页码:5110-5122 , 文章类型: Article,,卷期:2010年30-21]
- Nucleosome-free regions (NFRs) at the 5' and 3' ends of genes are general sites of transcription initiation for mRNA and noncoding RNA (ncRNA). The presence of NFRs within transcriptional regulatory regions and the conse...
- An Upstream Open Reading Frame and the Context of the Two AUG Codons Affect the Abundance of Mitochondrial and Nuclear RNase H1
[作者:Suzuki, Y; Holmes, JB; Cerritelli, SM; Sakhuja, K; Minczuk, M; Holt, IJ; Crouch, RJ,期刊:Molecular and Cellular Biology, 页码:5123-5134 , 文章类型: Article,,卷期:2010年30-21]
- RNase H1 in mammalian cells is present in nuclei and mitochondria. Its absence in mitochondria results in embryonic lethality due to the failure to amplify mitochondrial DNA (mtDNA). Dual localization to mitochondria and...
- Symplekin Specifies Mitotic Fidelity by Supporting Microtubule Dynamics
[作者:Cappell, KM; Larson, B; Sciaky, N; Whitehurst, AW,期刊:Molecular and Cellular Biology, 页码:5135-5144 , 文章类型: Article,,卷期:2010年30-21]
- Using a pangenomic loss-of-function screening strategy, we have previously identified 76 potent modulators of paclitaxel responsiveness in non-small-cell lung cancer. The top hit isolated from this screen, symplekin, is ...
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