- 14-3-3 (Bmh) Proteins Inhibit Transcription Activation by Adr1 through Direct Binding to Its Regulatory Domain
[作者:Parua, PK; Ratnakumar, S; Braun, KA; Dombek, KM; Arms, E; Ryan, PM; Young, ET,期刊:Molecular and Cellular Biology, 页码:5273-5283 , 文章类型: Article,,卷期:2010年30-22]
- 14-3-3 proteins, known as Bmh in yeast, are ubiquitous, highly conserved proteins that function as adaptors in signal transduction pathways by binding to phosphorylated proteins to activate, inactivate, or sequester thei...
- Cks1, Cdk1, and the 19S Proteasome Collaborate To Regulate Gene Induction-Dependent Nucleosome Eviction in Yeast
[作者:Chaves, S; Baskerville, C; Yu, V; Reed, SI,期刊:Molecular and Cellular Biology, 页码:5284-5294 , 文章类型: Article,,卷期:2010年30-22]
- Cks1, Cdk1 (Cdc28), and the proteasome are required for efficient transcriptional induction of GAL1 and other genes in Saccharomyces cerevisiae. We show here that one function of these proteins is to reduce nucleosome de...
- SHP2 Mediates the Localized Activation of Fyn Downstream of the alpha 6 beta 4 Integrin To Promote Carcinoma Invasion
[作者:Yang, XQ; Dutta, U; Shaw, LM,期刊:Molecular and Cellular Biology, 页码:5306-5317 , 文章类型: Article,,卷期:2010年30-22]
- Src family kinase (SFK) activity is elevated in many cancers, and this activity correlates with aggressive tumor behavior. The alpha 6 beta 4 integrin, which is also associated with a poor prognosis in many tumor types, ...
- The Fowler Syndrome-Associated Protein FLVCR2 Is an Importer of Heme
[作者:Duffy, SP; Shing, J; Saraon, P; Berger, LC; Eiden, MV; Wilde, A; Tailor, CS,期刊:Molecular and Cellular Biology, 页码:5318-5324 , 文章类型: Article,,卷期:2010年30-22]
- Mutations in FLVCR2, a cell surface protein related by homology and membrane topology to the heme exporter/retroviral receptor FLVCR1, have recently been associated with Fowler syndrome, a vascular disorder of the brain....
- Cdc13 N-Terminal Dimerization, DNA Binding, and Telomere Length Regulation
[作者:Mitchell, MT; Smith, JS; Mason, M; Harper, S; Speicher, DW; Johnson, FB; Skordalakes, E,期刊:Molecular and Cellular Biology, 页码:5325-5334 , 文章类型: Article,,卷期:2010年30-22]
- The essential yeast protein Cdc13 facilitates chromosome end replication by recruiting telomerase to telomeres, and together with its interacting partners Stn1 and Ten1, it protects chromosome ends from nucleolytic attac...
- MOF and H4 K16 Acetylation Play Important Roles in DNA Damage Repair by Modulating Recruitment of DNA Damage Repair Protein Mdc1
[作者:Li, XZ; Corsa, CAS; Pan, PW; Wu, LP; Ferguson, D; Yu, XC; Min, JR; Dou, YL,期刊:Molecular and Cellular Biology, 页码:5335-5347 , 文章类型: Article,,卷期:2010年30-22]
- MOF (MYST1) is the major enzyme to catalyze acetylation of histone H4 lysine 16 (K16) and is highly conserved through evolution. Using a conditional knockout mouse model and the derived mouse embryonic fibroblast cell li...
- Cooperative Action of Multiple cis-Acting Elements Is Required for N-myc Expression in Branchial Arches: Specific Contribution of GATA3
[作者:Potvin, E; Beuret, L; Cadrin-Girard, JF; Carter, M; Roy, S; Tremblay, M; Charron, J,期刊:Molecular and Cellular Biology, 页码:5348-5363 , 文章类型: Article,,卷期:2010年30-22]
- The precise expression of the N-myc proto-oncogene is essential for normal mammalian development, whereas altered N-myc gene regulation is known to be a determinant factor in tumor formation. Using transgenic mouse embry...
- Differential Roles of Sall4 Isoforms in Embryonic Stem Cell Pluripotency
[作者:Rao, S; Zhen, S; Roumiantsev, S; McDonald, LT; Yuan, GC; Orkin, SH,期刊:Molecular and Cellular Biology, 页码:5364-5380 , 文章类型: Article,,卷期:2010年30-22]
- Murine embryonic stem (ES) cells are defined by continuous self-renewal and pluripotency. A diverse repertoire of protein isoforms arising from alternative splicing is expressed in ES cells without defined biological rol...
- Forkhead Box M1 Transcription Factor Is Required for Macrophage Recruitment during Liver Repair
[作者:Ren, XM; Zhang, YF; Snyder, J; Cross, ER; Shah, TA; Kalin, TV; Kalinichenko, VV,期刊:Molecular and Cellular Biology, 页码:5381-5393 , 文章类型: Article,,卷期:2010年30-22]
- Acute liver injury results from exposure to toxins, pharmacological agents, or viral infections, contributing to significant morbidity and mortality worldwide. While hepatic inflammation is critical for liver repair, the...
- Widespread Overexpression of Epitope-Tagged Mdm4 Does Not Accelerate Tumor Formation In Vivo
[作者:De Clercq, S; Gembarska, A; Denecker, G; Maetens, M; Naessens, M; Haigh, K; Haigh, JJ; Marine, JC,期刊:Molecular and Cellular Biology, 页码:5394-5405 , 文章类型: Article,,卷期:2010年30-22]
- Mdm2 and Mdm4 are critical negative regulators of p53. A large body of evidence indicates that elevated expression of either Mdm2 or Mdm4 may favor tumor formation by inhibiting p53 tumor suppression function. To explore...
- Cyclic AMP Controls mTOR through Regulation of the Dynamic Interaction between Rheb and Phosphodiesterase 4D
[作者:Kim, HW; Ha, SH; Lee, MN; Huston, E; Kim, DH; Jang, SK; Suh, PG; Houslay, MD; Ryu, SH,期刊:Molecular and Cellular Biology, 页码:5406-5420 , 文章类型: Article,,卷期:2010年30-22]
- The mammalian target of rapamycin complex 1 (mTORC1) is a molecular hub that regulates protein synthesis in response to a number of extracellular stimuli. Cyclic AMP (cAMP) is considered to be an important second messeng...
- Spatial Regulation of Cyclic AMP-Epac1 Signaling in Cell Adhesion by ERM Proteins
[作者:Gloerich, M; Ponsioen, B; Vliem, MJ; Zhang, ZC; Zhao, J; Kooistra, MR; Price, LS; Ritsma, L; Zwartkruis, FJ; Rehmann, H; Jalink, K; Bos, JL,期刊:Molecular and Cellular Biology, 页码:5421-5431 , 文章类型: Article,,卷期:2010年30-22]
- Epac1 is a guanine nucleotide exchange factor for the small G protein Rap and is involved in membrane-localized processes such as integrin-mediated cell adhesion and cell-cell junction formation. Cyclic AMP (cAMP) direct...
- Structural Evidence for Loose Linkage between Ligand Binding and Kinase Activation in the Epidermal Growth Factor Receptor
[作者:Lu, CF; Mi, LZ; Grey, MJ; Zhu, JQ; Graef, E; Yokoyama, S; Springer, TA,期刊:Molecular and Cellular Biology, 页码:5432-5443 , 文章类型: Article,,卷期:2010年30-22]
- The mechanisms by which signals are transmitted across the plasma membrane to regulate signaling are largely unknown for receptors with single-pass transmembrane domains such as the epidermal growth factor receptor (EGFR...
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