- A Novel Approach for the Derivation of Putative Primordial Germ Cells and Sertoli Cells from Human Embryonic Stem Cells
[作者:Bucay, N; Yebra, M; Cirulli, V; Afrikanova, I; Kaido, T; Hayek, A; Montgomery, AMP,期刊:Stem Cells, 页码:68-77 , 文章类型: Article,,卷期:2009年27-1]
- Using human embryonic stem cells (hESCs), we describe a novel method for the rapid derivation and enrichment of cells that are comparable to primordial germ cells (PGCs) and Sertoli cells. The methodology described is ba...
- Lack of Laminin gamma 1 in Embryonic Stem Cell-Derived Cardiomyocytes Causes Inhomogeneous Electrical Spreading Despite Intact Differentiation and Function
[作者:Malan, D; Reppel, M; Dobrowolski, R; Roell, W; Smyth, N; Hescheler, J; Paulsson, M; Bloch, W; Fleischmann, BK,期刊:Stem Cells, 页码:88-99 , 文章类型: Article,,卷期:2009年27-1]
- Laminins form a large family of extracellular matrix (ECM) proteins, and their expression is a prerequisite for normal embryonic development. Herein we investigated the role of the laminin gamma 1 chain for cardiac muscl...
- Generation of T Lineage Cells from Human Embryonic Stem Cells in a Feeder Free System
[作者:Galic, Z; Kitchen, SG; Subramanian, A; Bristol, G; Marsden, MD; Balamurugan, A; Kacena, A; Yang, O; Zack, JA,期刊:Stem Cells, 页码:100-107 , 文章类型: Article,,卷期:2009年27-1]
- Human embryonic stem cells (hESC) have the potential to revolutionize certain medical treatments, including T-cell-based therapies. However, optimal approaches to develop T cells from hESC are lacking. In this report, we...
- Chromatin Modifications in Hematopoietic Multipotent and Committed Progenitors Are Independent of Gene Subnuclear Positioning Relative to Repressive Compartments
[作者:Guillemin, C; Maleszewska, M; Guais, A; Maes, J; Rouyez, MC; Yacia, A; Fichelson, S; Goodhardt, M; Francastel, C,期刊:Stem Cells, 页码:108-115 , 文章类型: Article,,卷期:2009年27-1]
- To further clarify the contribution of nuclear architecture in the regulation of gene expression patterns during differentiation of human multipotent cells, we analyzed expression status, histone modifications, and subnu...
- Superior Osteogenic Capacity for Bone Tissue Engineering of Fetal Compared with Perinatal and Adult Mesenchymal Stem Cells
[作者:Zhang, ZY; Teoh, SH; Chong, MSK; Schantz, JT; Fisk, NM; Choolani, MA; Chan, J,期刊:Stem Cells, 页码:126-137 , 文章类型: Article,,卷期:2009年27-1]
- Mesenchymal stem cells (MSCs) from human adult bone marrow (haMSCs) represent a promising source for bone tissue engineering. However, their low frequencies and limited proliferation restrict their clinical utility. Alte...
- Isolation and Characterization of Pluripotent Human Spermatogonial Stem Cell-Derived Cells
[作者:Kossack, N; Meneses, J; Shefi, S; Nguyen, HN; Chavez, S; Nicholas, C; Gromoll, J; Turek, PJ; Reijo-Pera, RA,期刊:Stem Cells, 页码:138-149 , 文章类型: Article,,卷期:2009年27-1]
- Several reports have documented the derivation of pluripotent cells (multipotent germline stem cells) from spermatogonial stem cells obtained from the adult mouse testis. These spermatogonia-derived stem cells express em...
- Dysregulation of Local Stem/Progenitor Cells as a Common Cellular Mechanism for Heterotopic Ossification
[作者:Kan, LX; Liu, YJ; McGuire, TL; Berger, DMP; Awatramani, RB; Dymecki, SM; Kessler, JA,期刊:Stem Cells, 页码:150-156 , 文章类型: Article,,卷期:2009年27-1]
- Heterotopic ossification (HO), the abnormal formation of true marrow-containing bone within extraskeletal soft tissues, is a serious bony disorder that may be either acquired or hereditary. We utilized an animal model of...
- Skeletal Muscle Differentiation of Embryonic Mesoangioblasts Requires Pax3 Activity
[作者:Messina, G; Sirabella, D; Monteverde, S; Galvez, BG; Tonlorenzi, R; Schnapp, E; De Angelis, L; Brunelli, S; Relaix, F; Buckingham, M; Cossu, G,期刊:Stem Cells, 页码:157-164 , 文章类型: Article,,卷期:2009年27-1]
- Mesoangioblasts have been characterized as a population of vessel-associated stem cells able to differentiate into several mesodermal cell types, including skeletal muscle. Here, we report that the paired box transcripti...
- Gli2 Is a Novel Regulator of Sox2 Expression in Telencephalic Neuroepithelial Cells
[作者:Takanaga, H; Tsuchida-Straeten, N; Nishide, K; Watanabe, A; Aburatani, H; Kondo, T,期刊:Stem Cells, 页码:165-174 , 文章类型: Article,,卷期:2009年27-1]
- Multipotential neural stem cells (NSCs) in the central nervous system (CNS) proliferate indefinitely and give rise to neurons, astrocytes, and oligodendrocytes. As NSCs hold promise for CNS regeneration, it is important ...
- Hypoxia and HIF1 alpha Repress the Differentiative Effects of BMPs in High-Grade Glioma
[作者:Pistollato, F; Chen, HL; Rood, BR; Zhang, HZ; D'Avella, D; Denaro, L; Gardiman, M; Kronnie, GT; Schwartz, PH; Favaro, E; Indraccolo, S; Basso, G; Panchision, DM,期刊:Stem Cells, 页码:7-17 , 文章类型: Article,,卷期:2009年27-1]
- Hypoxia commonly occurs in solid tumors of the central nervous system (CNS) and often interferes with therapies designed to stop their growth. We found that pediatric high-grade glioma (HGG)-derived precursors showed gre...
- A Self-Renewal Program Controls the Expansion of Genetically Unstable Cancer Stem Cells in Pluripotent Stem Cell-Derived Tumors
[作者:Conway, AE; Lindgren, A; Galic, Z; Pyle, AD; Wu, H; Zack, JA; Pelligrini, M; Teitell, MA; Clark, AT,期刊:Stem Cells, 页码:18-28 , 文章类型: Article,,卷期:2009年27-1]
- Human germ cell tumors are often metastatic, presumably due to distal site tumor growth by cancer stem cells. To determine whether cancer stem cells can be identified in a transplantation model of testicular germ cell tu...
- Cryopreservation of Neurospheres Derived from Human Glioblastoma Multiforme
[作者:Chong, YK; Toh, TB; Zaiden, N; Poonepalli, A; Leong, SH; Ong, CEL; Yu, Y; Tan, PB; See, SJ; Ng, WH; Ng, I; Hande, MP; Kon, OL; Ang, BT; Tang, C,期刊:Stem Cells, 页码:29-39 , 文章类型: Article,,卷期:2009年27-1]
- Cancer stem cells have been shown to initiate and sustain tumor growth. In many instances, clinical material is limited, compounded by a lack of methods to preserve such cells at convenient time points. Although brain tu...
- SOX2 Silencing in Glioblastoma Tumor-Initiating Cells Causes Stop of Proliferation and Loss of Tumorigenicity
[作者:Gangemi, RMR; Griffero, F; Marubbi, D; Perera, M; Capra, MC; Malatesta, P; Ravetti, GL; Zona, GL; Daga, A; Corte, G,期刊:Stem Cells, 页码:40-48 , 文章类型: Article,,卷期:2009年27-1]
- Glioblastoma, the most aggressive cerebral tumor, is invariably lethal. Glioblastoma cells express several genes typical of normal neural stem cells. One of them, SOX2, is a master gene involved in sustaining self-renewa...
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