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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共15条记录   Ospemifene use in postmenopausal women [作者：Gennari, L; Merlotti, D; Valleggi, F; Nuti, R,期刊：Expert opinion on investigational drugs, 页码：839-849 , 文章类型： Article，,卷期：2009年18-6] Background: Selective estrogen receptor modulators (SERMs) are structurally different compounds that interact with intracellular estrogen receptors in target organs as estrogen agonists and antagonists. These drugs have ... Degarelix for prostate cancer [作者：Doehn, C; Sommerauer, M; Jocham, D,期刊：Expert opinion on investigational drugs, 页码：851-860 , 文章类型： Article，,卷期：2009年18-6] The growth of prostate cancer cells is hormone dependent in the majority of patients with the disease. Lowering testosterone either surgically or medically (usually with a gonadotropin releasing hormone (GnRH) agonist) i... Tanespimycin: the opportunities and challenges of targeting heat shock protein 90 [作者：Erlichman, C,期刊：Expert opinion on investigational drugs, 页码：861-868 , 文章类型： Article，,卷期：2009年18-6] Background: Heat shock protein 90 (HSP90) is the core of a multi-chaperone complex critical for the folding, trafficking, and stabilization of many client proteins that are involved in tumor cell proliferation, survival,... Mepolizumab for difficult-to-control asthma with persistent sputum eosinophilia [作者：Antoniu, SA,期刊：Expert opinion on investigational drugs, 页码：869-871 , 文章类型： Article，,卷期：2009年18-6] Background: In asthma, anti-inflammatory therapy can usually reduce airway eosinophilic inflammation; but in certain subgroups this persists despite maximal therapy, and disease control is suboptimal. Mepolizumab is an a... Belinostat: a new broad acting antineoplastic histone deacetylase inhibitor (vol 18, pg 501, 2009) [作者：Gimsing, P,期刊：Expert opinion on investigational drugs, 页码：873-873 , 文章类型： Correction，,卷期：2009年18-6] New antifungal therapies for the treatment of onychomycosis [作者：Kumar, S; Kimball, AB,期刊：Expert opinion on investigational drugs, 页码：727-734 , 文章类型： Review，,卷期：2009年18-6] Onychomycosis is a common disorder of nails caused by diverse spectrum of fungi ranging from dermatophytes to nondermatophyte molds and yeasts. Presently, oral and topical therapies are the mainstay of treatment with ora... Invasive candidiasis and candidemia: from current opinions to future perspectives [作者：Rueping, MJGT; Vehreschild, JJ; Cornely, OA,期刊：Expert opinion on investigational drugs, 页码：735-748 , 文章类型： Review，,卷期：2009年18-6] Candida spp. are the fourth most common cause of nosocomial bloodstream infections in the United States, as well as the single most important cause of opportunistic fungal infections worldwide. A delayed diagnosis of inv... Prostaglandin EP2 and EP4 receptor agonists in bone formation and bone healing: In vivo and in vitro evidence [作者：Graham, S; Gamie, Z; Polyzois, I; Narvani, AA; Tzafetta, K; Tsiridis, E; Helioti, M; Mantalaris, A; Tsiridis, E,期刊：Expert opinion on investigational drugs, 页码：749-766 , 文章类型： Review，,卷期：2009年18-6] Background: Using agonists that selectively stimulate PGE(2) receptors, the adverse effects that have limited the clinical utility of PGE(2) can be avoided and there may be potential for their use as therapeutic agents i... Current investigational drugs for major depression [作者：Kulkarni, SK; Dhir, A,期刊：Expert opinion on investigational drugs, 页码：767-788 , 文章类型： Review，,卷期：2009年18-6] Background: The World Health Organization (WHO) report has predicted that major depression will become a key cause of illness-induced disability by the year 2020, second only to ischemic heart diseases. Objectives/method... Therapeutic potential of novel glutamate receptor antagonists in migraine [作者：Andreou, AP; Goadsby, PJ,期刊：Expert opinion on investigational drugs, 页码：789-803 , 文章类型： Review，,卷期：2009年18-6] Background: Migraine is a common and disabling neurological disorder. Although the pharmacotherapy of migraine has advanced in parallel with our understanding of the pathophysiology of the disease, there is still a consi... New treatments for idiopathic thrombocytopenic purpura: rethinking old hypotheses [作者：Arnold, DM; Nazi, I; Kelton, JG,期刊：Expert opinion on investigational drugs, 页码：805-819 , 文章类型： Review，,卷期：2009年18-6] Background: The efficacy of thrombopoietin (TPO) mimetics in patients with idiopathic thrombocytopenic purpura (ITP) reaffirms that impaired platelet production is an important mechanism. New strategies to reduce platele... Sunitinib in solid tumors [作者：Gan, HK; Seruga, B; Knox, JJ,期刊：Expert opinion on investigational drugs, 页码：821-834 , 文章类型： Review，,卷期：2009年18-6] Background: Until recently, few treatments were available for renal cell carcinoma (RCC) and gastrointestinal stromal tumors (GIST). Several targeted agents inhibiting key pathogenetic pathways have since been developed ... Inhibition of dipeptidyl peptidase 4 by BI-1356, a new drug for the treatment of beta-cell failure in type 2 diabetes [作者：Rungby, J,期刊：Expert opinion on investigational drugs, 页码：835-838 , 文章类型： Article，,卷期：2009年18-6] BI 1356, a xanthine-based DPP-4 inhibitor, has reached Phase III trials. The compound efficiently inhibits dipeptidyl peptidase 4 (DPP-4) in vitro and in vivo. In vivo GLP-1 levels increase to levels at or above the leve... Current drugs and medical treatment algorithms in the management of acute decompensated heart failure [作者：Triposkiadis, F; Parissis, JT; Starling, RC; Skoularigis, J; Louridas, G,期刊：Expert opinion on investigational drugs, 页码：695-707 , 文章类型： Article，,卷期：2009年18-6] Background: Acute decompensated heart failure (ADHF) is associated with increased hospitalization rates and high in-hospital mortality, and has emerged as a major public health problem over the past decade. In recent yea... Progress towards improving antiviral therapy for hepatitis C with hepatitis C virus polymerase inhibitors. Part I: Nucleoside analogues [作者：Brown, NA,期刊：Expert opinion on investigational drugs, 页码：709-725 , 文章类型： Review，,卷期：2009年18-6] Background: With an increasing worldwide burden of liver failure and liver cancer from chronic hepatitis C virus (HCV) infection, discovery and development efforts for new antiviral medicines for HCV are expanding rapidl...