- Induction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistance
[作者:Lu, CW; Lin, SC; Chen, KF; Lai, YY; Tsai, SJ,期刊:Journal of Biological Chemistry, 页码:28106-28114 , 文章类型: Article,,卷期:2008年283-42]
- The switch of cellular metabolism from mitochondrial respiration to glycolysis is the hallmark of cancer cells and associated with tumor malignancy. However, the mechanism of this metabolic switch remains largely unknown...
- Human follicular fluid heparan sulfate contains abundant 3-O-sulfated chains with anticoagulant activity
[作者:de Agostini, AI; Dong, JC; Arrighi, CD; Ramus, MA; Dentand-Quadri, I; Thalmann, S; Ventura, P; Ibecheole, V; Monge, F; Fischer, AM; HajMohammadi, S; Shworak, NW; Zhang, LJ; Zhang, Z; Linhardt, RJ,期刊:Journal of Biological Chemistry, 页码:28115-28124 , 文章类型: Article,,卷期:2008年283-42]
- Anticoagulant heparan sulfate proteoglycans bind and activate antithrombin by virtue of a specific 3-O-sulfated pentasaccharide. They not only occur in the vascular wall but also in extravascular tissues, such as the ova...
- Demonstration of the iron-regulated surface determinant (Isd) heme transfer pathway in Staphylococcus aureus
[作者:Muryoi, N; Tiedemann, MT; Pluym, M; Cheung, J; Heinrichs, DE; Stillman, MJ,期刊:Journal of Biological Chemistry, 页码:28125-28136 , 文章类型: Article,,卷期:2008年283-42]
- In this study, we report experimental results that provide the first complete challenge of a proposed model for heme acquisition by Staphylococcus aureus via the Isd pathway first put forth by Mazmanian, S. K., Skaar, E....
- Contribution of each membrane binding domain of the CTP : phosphocholine cytidylyltransferase-alpha dimer to its activation, membrane binding, and membrane cross-bridging
[作者:Taneva, S; Dennis, MK; Ding, Z; Smith, JL; Cornell, RB,期刊:Journal of Biological Chemistry, 页码:28137-28148 , 文章类型: Article,,卷期:2008年283-42]
- CTP:phosphocholine cytidylyltransferase (CCT), a rate-limiting enzyme in phosphatidylcholine synthesis, is regulated by reversible membrane interactions mediated by an amphipathic helical domain ( M) that binds selective...
- Laminin isoforms containing the gamma 3 chain are unable to bind to integrins due to the absence of the glutamic acid residue conserved in the C-terminal regions of the gamma 1 and gamma 2 chains
[作者:Ido, H; Ito, S; Taniguchi, Y; Hayashi, M; Sato-Nishiuchi, R; Sanzen, N; Hayashi, Y; Futaki, S; Sekiguchi, K,期刊:Journal of Biological Chemistry, 页码:28149-28157 , 文章类型: Article,,卷期:2008年283-42]
- Laminins are the major cell adhesive proteins in basement membranes, and consist of three subunits termed alpha, beta, and gamma. Recently, we found that the Glu residue at the third position from the C termini of the ga...
- Modulation of the regulatory activity of bacterial two-component systems by SlyA
[作者:Song, HW; Kong, W; Weatherspoon, N; Qin, GZ; Tyler, W; Turk, J; Curtiss, R; Shi, YX,期刊:Journal of Biological Chemistry, 页码:28158-28168 , 文章类型: Article,,卷期:2008年283-42]
- Activation of the transcriptional regulator SlyA by the PhoP/PhoQ two-component system controls intracellular expression of numerous factors influencing Salmonella virulence. By dissecting the SlyA regulon using stable i...
- Species-specific cis-regulatory elements in the 3 '-untranslated region direct alternative polyadenylation of bone morphogenetic protein 2 mRNA
[作者:Liu, DL; Fritz, DT; Rogers, MB; Shatkin, AJ,期刊:Journal of Biological Chemistry, 页码:28010-28019 , 文章类型: Article,,卷期:2008年283-42]
- BMP2 (bone morphogenetic protein 2) is a multifunctional member of the transforming growth factor-beta family of growth factors. Disruption of BMP2 signaling results in developmental defects, cancers, and other diseases....
- Proteinase-activated receptor 2 stimulates Na,K-ATPase and sodium reabsorption in native kidney epithelium
[作者:Morla, L; Crambert, G; Mordasini, D; Favre, G; Doucet, A; Imbert-Teboul, M,期刊:Journal of Biological Chemistry, 页码:28020-28028 , 文章类型: Article,,卷期:2008年283-42]
- Proteinase-activated receptors 2 (PAR2) are expressed in kidney, but their function is mostly unknown. Since PAR2 control ion transport in several epithelia, we searched for an effect on sodium transport in the cortical ...
- Kinetic analysis of L1 homophilic interaction - Role of the first four immunoglobulin domains and implications on binding mechanism
[作者:Gouveia, RM; Gomes, CM; Sousa, M; Alves, PM; Costa, J,期刊:Journal of Biological Chemistry, 页码:28038-28047 , 文章类型: Article,,卷期:2008年283-42]
- L1 is a cell adhesion molecule of the immunoglobulin (Ig) superfamily, critical for central nervous system development, and involved in several neuronal biological events. It is a type I membrane glycoprotein. The L1 ect...
- Impaired anaplerosis and insulin secretion in insulinoma cells caused by small interfering RNA-mediated suppression of pyruvate carboxylase
[作者:Hasan, NM; Longacre, MJ; Stoker, SW; Boonsaen, T; Jitrapakdee, S; Kendrick, MA; Wallace, JC; MacDonald, MJ,期刊:Journal of Biological Chemistry, 页码:28048-28059 , 文章类型: Article,,卷期:2008年283-42]
- Anaplerosis, the synthesis of citric acid cycle intermediates, by pancreatic beta cell mitochondria has been proposed to be as important for insulin secretion as mitochondrial energy production. However, studies designed...
- Hsp90-mediated assembly of the 26 S proteasome is involved in major histocompatibility complex class I antigen processing
[作者:Yamano, T; Mizukami, S; Murata, S; Chiba, T; Tanaka, K; Udono, H,期刊:Journal of Biological Chemistry, 页码:28060-28065 , 文章类型: Article,,卷期:2008年283-42]
- Heat shock protein 90 (hsp90) and the proteasome activator PA28 stimulate major histocompatibility complex (MHC) class I antigen processing. It is unknown whether hsp90 influences the proteasome activity to produce T cel...
- Protein-nanocrystal conjugates support a single filament polymerization model in R1 plasmid segregation
[作者:Choi, CL; Claridge, SA; Garner, EC; Alivisatos, AP; Mullins, RD,期刊:Journal of Biological Chemistry, 页码:28081-28086 , 文章类型: Article,,卷期:2008年283-42]
- To ensure inheritance by daughter cells, many low-copy number bacterial plasmids, including the R1 drug-resistance plasmid, encode their own DNA segregation systems. The par operon of plasmid R1 directs construction of a...
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