- A novel lentiviral vector targets gene transfer into human hematopoietic stem cells in marrow from patients with bone marrow failure syndrome and in vivo in humanized mice
[作者:Frecha, C; Costa, C; Negre, D; Amirache, F; Trono, D; Rio, P; Bueren, J; Cosset, FL; Verhoeyen, E,期刊:Blood, 页码:1139-1150 , 文章类型: Article,,卷期:2012年119-5]
- In vivo lentiviral vector (LV)-mediated gene delivery would represent a great step forward in the field of gene therapy. Therefore, we have engineered a novel LV displaying SCF and a mutant cat endogenous retroviral glyc...
- Histone deacetylases mediate the silencing of miR-15a, miR-16, and miR-29b in chronic lymphocytic leukemia
[作者:Sampath, D; Liu, CM; Vasan, K; Sulda, M; Puduvalli, VK; Wierda, WG; Keating, MJ,期刊:Blood, 页码:1162-1172 , 文章类型: Article,,卷期:2012年119-5]
- Chronic lymphocytic leukemia (CLL) demonstrates a global down-regulation of miR-15a and miR-16 and a selective silencing of the related miR-29b in aggressive disease. Deletions in chromosome 13 [del(13q14)] partially acc...
- The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo
[作者:Ponader, S; Chen, SS; Buggy, JJ; Balakrishnan, K; Gandhi, V; Wierda, WG; Keating, MJ; O'Brien, S; Chiorazzi, N; Burger, JA,期刊:Blood, 页码:1182-1189 , 文章类型: Article,,卷期:2012年119-5]
- B-cell receptor (BCR) signaling is a critical pathway in the pathogenesis of several B-cell malignancies, including chronic lymphocytic leukemia (CLL), and can be targeted by inhibitors of BCR-associated kinases, such as...
- The cell cycle regulator CDC25A is a target for JAK2(V617F) oncogene
[作者:Gautier, EF; Picard, M; Laurent, C; Marty, C; Villeval, JL; Demur, C; Delhommeau, F; Hexner, E; Giraudier, S; Bonnevialle, N; Ducommun, B; Recher, C; Laurent, G; Manenti, S; Mansat-De Mas, V,期刊:Blood, 页码:1190-1199 , 文章类型: Article,,卷期:2012年119-5]
- The JAK2(V617F) mutation is present in the majority of patients with polycythemia vera and one-half of those with essential thrombocythemia and primary myelofibrosis. JAK2(V617F) is a gain-of-function mutation resulting ...
- A small molecule screening strategy with validation on human leukemia stem cells uncovers the therapeutic efficacy of kinetin riboside
[作者:McDermott, SP; Eppert, K; Notta, F; Isaac, M; Datti, A; Al-awar, R; Wrana, J; Minden, MD; Dick, JE,期刊:Blood, 页码:1200-1207 , 文章类型: Article,,卷期:2012年119-5]
- Gene regulatory networks that govern hematopoietic stem cells (HSCs) and leukemia-initiating cells (L-ICs) are deeply entangled. Thus, the discovery of compounds that target L-ICs while sparing HSC is an attractive but d...
- Inactivation of polycomb repressive complex 2 components in myeloproliferative and myelodysplastic/myeloproliferative neoplasms
[作者:Score, J; Hidalgo-Curtis, C; Jones, AV; Winkelmann, N; Skinner, A; Ward, D; Zoi, K; Ernst, T; Stegelmann, F; Dohner, K; Chase, A; Cross, NCP,期刊:Blood, 页码:1208-1213 , 文章类型: Article,,卷期:2012年119-5]
- The polycomb repressive complex 2 (PRC2) is a highly conserved histone H3 lysine 27 methyltransferase that regulates the expression of developmental genes. Inactivating mutations of the catalytic component of PRC2, EZH2,...
- Killing by neutrophil extracellular traps: fact or folklore?
[作者:Menegazzi, R; Decleva, E; Dri, P,期刊:Blood, 页码:1214-1216 , 文章类型: Article,,卷期:2012年119-5]
- Neutrophil extracellular traps (NETs) are DNA structures released by dying neutrophils and claimed to constitute a new microbicidal mechanism. Killing by NET-forming cells is ascribed to these structures because it is pr...
- Erythrocyte plasma membrane-bound ERK1/2 activation promotes ICAM-4-mediated sickle red cell adhesion to endothelium
[作者:Zennadi, R; Whalen, EJ; Soderblom, EJ; Alexander, SC; Thompson, JW; Dubois, LG; Moseley, MA; Telen, MJ,期刊:Blood, 页码:1217-1227 , 文章类型: Article,,卷期:2012年119-5]
- The core pathology of sickle cell disease (SCD) starts with the erythrocyte (RBC). Aberration in MAPK/ERK1/2 signaling, which can regulate cell adhesion, occurs in diverse pathologies. Because RBCs contain abundant ERK1/...
- Contrasting dynamic responses in vivo of the Bcl-x(L) and Bim erythropoietic survival pathways
[作者:Koulnis, M; Porpiglia, E; Porpiglia, PA; Liu, Y; Hallstrom, K; Hidalgo, D; Socolovsky, M,期刊:Blood, 页码:1228-1239 , 文章类型: Article,,卷期:2012年119-5]
- Survival signaling by the erythropoietin (Epo) receptor (EpoR) is essential for erythropoiesis and for its acceleration in hypoxic stress. Several apparently redundant EpoR survival pathways were identified in vitro, rai...
- Effects of tetrahydrouridine on pharmacokinetics and pharmacodynamics of oral decitabine
[作者:Lavelle, D; Vaitkus, K; Ling, YH; Ruiz, MA; Mahfouz, R; Ng, KP; Negrotto, S; Smith, N; Terse, P; Engelke, KJ; Covey, J; Chan, KK; DeSimone, J; Saunthararajah, Y,期刊:Blood, 页码:1240-1247 , 文章类型: Article,,卷期:2012年119-5]
- The deoxycytidine analog decitabine (DAC) can deplete DNA methyl-transferase 1 (DNMT1) and thereby modify cellular epigenetics, gene expression, and differentiation. However, a barrier to efficacious and accessible DNMT1...
- Heparin-induced thrombocytopenia: in vitro studies on the interaction of dabigatran, rivaroxaban, and low-sulfated heparin, with platelet factor 4 and anti-PF4/heparin antibodies
[作者:Krauel, K; Hackbarth, C; Furll, B; Greinacher, A,期刊:Blood, 页码:1248-1255 , 文章类型: Article,,卷期:2012年119-5]
- Heparin is a widely used anticoagulant. Because of its negative charge, it forms complexes with positively charged platelet factor 4 (PF4). This can induce anti-PF4/heparin IgG Abs. Resulting immune complexes activate pl...
- Desialylation accelerates platelet clearance after refrigeration and initiates GPIb alpha metalloproteinase-mediated cleavage in mice
[作者:Jansen, AJG; Josefsson, EC; Rumjantseva, V; Liu, QP; Falet, H; Bergmeier, W; Cifuni, SM; Sackstein, R; von Andrian, UH; Wagner, DD; Hartwig, JH; Hoffmeister, KM,期刊:Blood, 页码:1263-1273 , 文章类型: Article,,卷期:2012年119-5]
- When refrigerated platelets are rewarmed, they secrete active sialidases, including the lysosomal sialidase Neu1, and express surface Neu3 that remove sialic acid from platelet von Willebrand factor receptor (VWFR), spec...
- Inhibition of histone methylation arrests ongoing graft-versus-host disease in mice by selectively inducing apoptosis of alloreactive effector T cells
[作者:He, S; Wang, JN; Kato, K; Xie, F; Varambally, S; Mineishi, S; Kuick, R; Mochizuki, K; Liu, YNA; Nieves, E; Mani, RS; Chinnaiyan, AM; Marquez, VE; Zhang, Y,期刊:Blood, 页码:1274-1282 , 文章类型: Article,,卷期:2012年119-5]
- Histone methylation is thought to be important for regulating Ag-driven T-cell responses. However, little is known about the effect of modulating histone methylation on inflammatory T-cell responses. We demonstrate that ...
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