- Mutant Huntingtin Impairs Vesicle Formation from Recycling Endosomes by Interfering with Rab11 Activity
[作者:Li, XY; Standley, C; Sapp, E; Valencia, A; Qin, ZH; Kegel, KB; Yoder, J; Comer-Tierney, LA; Esteves, M; Chase, K; Alexander, J; Masso, N; Sobin, L; Bellve, K; Tuft, R; Lifshitz, L; Fogarty, K; Aronin, N; DiFiglia, M,期刊:Molecular and Cellular Biology, 页码:6106-6116 , 文章类型: Article,,卷期:2009年29-22]
- Huntingtin (Htt) localizes to endosomes, but its role in the endocytic pathway is not established. Recently, we found that Htt is important for the activation of Rab11, a GTPase involved in endosomal recycling. Here we s...
- A Novel GGA-Binding Site Is Required for Intracellular Sorting Mediated by Stabilin-1
[作者:Zhang, JJ; Gratchev, A; Riabov, V; Mamidi, S; Schmuttermaier, C; Krusell, L; Kremmer, E; Workman, G; Sage, EH; Jalkanen, S; Goerdt, S; Kzhyshkowska, J,期刊:Molecular and Cellular Biology, 页码:6097-6105 , 文章类型: Article,,卷期:2009年29-22]
- Stabilin-1 is a unique scavenger receptor that combines endocytic and intracellular sorting functions in macrophages. Stabilin-1 mediates the endocytosis of acetylated low-density lipoprotein (acLDL), SPARC, and growth h...
- Translational Control of Protein Kinase C eta by Two Upstream Open Reading Frames
[作者:Raveh-Amit, H; Maissel, A; Poller, J; Marom, L; Elroy-Stein, O; Shapira, M; Livneh, E,期刊:Molecular and Cellular Biology, 页码:6140-6148 , 文章类型: Article,,卷期:2009年29-22]
- Protein kinase C (PKC) represents a family of serine/threonine kinases that play a central role in the regulation of cell growth, differentiation, and transformation. Posttranslational control of the PKC isoforms and the...
- Stimulus-Specific Distinctions in Spatial and Temporal Dynamics of Stress-Activated Protein Kinase Kinase Kinases Revealed by a Fluorescence Resonance Energy Transfer Biosensor
[作者:Tomida, T; Takekawa, M; O'Grady, P; Saito, H,期刊:Molecular and Cellular Biology, 页码:6117-6127 , 文章类型: Article,,卷期:2009年29-22]
- The stress-activated protein kinases (SAPKs), namely, p38 and JNK, are members of the mitogen-activated protein kinase family and are important determinants of cell fate when cells are exposed to environmental stresses s...
- Genetic and Functional Interactions between the Mitochondrial Outer Membrane Proteins Tom6 and Sam37
[作者:Dukanovic, J; Dimmer, KS; Bonnefoy, N; Krumpe, K; Rapaport, D,期刊:Molecular and Cellular Biology, 页码:5975-5988 , 文章类型: Article,,卷期:2009年29-22]
- The TOM complex is the general mitochondrial entry site for newly synthesized proteins. Precursors of beta-barrel proteins initially follow this common pathway and are then relayed to the SAM/TOB complex, which mediates ...
- Meiotic DNA Double-Strand Break Repair Requires Two Nucleases, MRN and Ctp1, To Produce a Single Size Class of Rec12 (Spo11)-Oligonucleotide Complexes
[作者:Milman, N; Higuchi, E; Smith, GR,期刊:Molecular and Cellular Biology, 页码:5998-6005 , 文章类型: Article,,卷期:2009年29-22]
- Programmed DNA double-strand breaks (DSBs) in meiosis are formed by Spo11 (Rec12 in fission yeast), a topoisomerase II-like protein, which becomes covalently attached to DNA 5' ends. For DSB repair through homologous rec...
- Cyclic GMP Kinase and RhoA Ser188 Phosphorylation Integrate Pro- and Antifibrotic Signals in Blood Vessels
[作者:Sawada, N; Itoh, H; Miyashita, K; Tsujimoto, H; Sone, M; Yamahara, K; Arany, ZP; Hofmann, F; Nakao, K,期刊:Molecular and Cellular Biology, 页码:6018-6032 , 文章类型: Article,,卷期:2009年29-22]
- Vascular fibrosis is a major complication of hypertension and atherosclerosis, yet it is largely untreatable. Natriuretic peptides (NPs) repress fibrogenic activation of vascular smooth muscle cells (VSMCs), but the intr...
- Nuclear Factor I-C Links Platelet-Derived Growth Factor and Transforming Growth Factor beta 1 Signaling to Skin Wound Healing Progression
[作者:Plasari, G; Calabrese, A; Dusserre, Y; Gronostajski, RM; Mcnair, A; Michalik, L; Mermod, N,期刊:Molecular and Cellular Biology, 页码:6006-6017 , 文章类型: Article,,卷期:2009年29-22]
- Transforming growth factor beta (TGF-beta) and platelet-derived growth factor A (PDGF beta) play a central role in tissue morphogenesis and repair, but their interplay remain poorly understood. The nuclear factor I C (NF...
- Muscle Lim Protein Interacts with Cofilin 2 and Regulates F-Actin Dynamics in Cardiac and Skeletal Muscle
[作者:Papalouka, V; Arvanitis, DA; Vafiadaki, E; Mavroidis, M; Papadodima, SA; Spiliopoulou, CA; Kremastinos, DT; Kranias, EG; Sanoudou, D,期刊:Molecular and Cellular Biology, 页码:6046-6058 , 文章类型: Article,,卷期:2009年29-22]
- The muscle LIM protein (MLP) and cofilin 2 (CFL2) are important regulators of striated myocyte function. Mutations in the corresponding genes have been directly associated with severe human cardiac and skeletal myopathie...
- Human Ind1, an Iron-Sulfur Cluster Assembly Factor for Respiratory Complex I
[作者:Sheftel, AD; Stehling, O; Pierik, AJ; Netz, DJA; Kerscher, S; Elsasser, HP; Wittig, I; Balk, J; Brandt, U; Lill, R,期刊:Molecular and Cellular Biology, 页码:6059-6073 , 文章类型: Article,,卷期:2009年29-22]
- Respiratory complex I (NADH: ubiquinone oxidoreductase) is a large mitochondrial inner membrane enzyme consisting of 45 subunits and 8 iron-sulfur (Fe/S) clusters. While complex I dysfunction is the most common reason fo...
- Global Analysis of H3K4 Methylation Defines MLL Family Member Targets and Points to a Role for MLL1-Mediated H3K4 Methylation in the Regulation of Transcriptional Initiation by RNA Polymerase II
[作者:Wang, PF; Lin, CQ; Smith, ER; Guo, H; Sanderson, BW; Wu, M; Gogol, M; Alexander, T; Seidel, C; Wiedemann, LM; Ge, K; Krumlauf, R; Shilatifard, A,期刊:Molecular and Cellular Biology, 页码:6074-6085 , 文章类型: Article,,卷期:2009年29-22]
- A common landmark of activated genes is the presence of trimethylation on lysine 4 of histone H3 (H3K4) at promoter regions. Set1/COMPASS was the founding member and is the only H3K4 methylase in Saccharomyces cerevisiae...
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