- Bim Upregulation by Histone Deacetylase Inhibitors Mediates Interactions with the Bcl-2 Antagonist ABT-737: Evidence for Distinct Roles for Bcl-2, Bcl-x(L), and Mcl-1
[作者:Chen, S; Dai, Y; Pei, XY; Grant, S,期刊:Molecular and Cellular Biology, 页码:6149-6169 , 文章类型: Article,,卷期:2009年29-23]
- The Bcl-2 antagonist ABT-737 kills transformed cells in association with displacement of Bim from Bcl-2. The histone deactetylase (HDAC) inhibitor suberoyl bis-hydroxamic acid (SBHA) was employed to determine whether and...
- S-Adenosyl Homocysteine Hydrolase Is Required for Myc-Induced mRNA Cap Methylation, Protein Synthesis, and Cell Proliferation
[作者:Fernandez-Sanchez, ME; Gonatopoulos-Pournatzis, T; Preston, G; Lawlor, MA; Cowling, VH,期刊:Molecular and Cellular Biology, 页码:6182-6191 , 文章类型: Article,,卷期:2009年29-23]
- The c-Myc proto-oncogene promotes mRNA cap methylation, which is essential for almost all mRNA translation. The mRNA cap methylation reaction produces an inhibitory byproduct, S-adenosyl homocysteine. Here we report that...
- Human SNF5/INI1, a Component of the Human SWI/SNF Chromatin Remodeling Complex, Promotes Nucleotide Excision Repair by Influencing ATM Recruitment and Downstream H2AX Phosphorylation
[作者:Ray, A; Mir, SN; Wani, G; Zhao, Q; Battu, A; Zhu, QZ; Wang, QE; Wani, AA,期刊:Molecular and Cellular Biology, 页码:6206-6219 , 文章类型: Article,,卷期:2009年29-23]
- Recent studies have implicated the role of the SWI/SNF ATP-dependent chromatin remodeling complex in nuclear excision repair (NER), but the mechanism of its function has remained elusive. Here, we show that the human SWI...
- Structural Basis of Alternative DNA Recognition by Maf Transcription Factors
[作者:Kurokawa, H; Motohashi, H; Sueno, S; Kimura, M; Takagawa, H; Kanno, Y; Yamamoto, M; Tanaka, T,期刊:Molecular and Cellular Biology, 页码:6232-6244 , 文章类型: Article,,卷期:2009年29-23]
- Maf transcription factors constitute a family of the basic region-leucine zipper (bZip) factors and recognize unusually long DNA motifs (13 or 14 bp), termed the Maf recognition element (MARE). The MARE harbors extended ...
- Changes in Retinoblastoma Cell Adhesion Associated with Optic Nerve Invasion
[作者:Laurie, N; Mohan, A; McEvoy, J; Reed, D; Zhang, JK; Schweers, B; Ajioka, I; Valentine, V; Johnson, D; Ellison, D; Dyer, MA,期刊:Molecular and Cellular Biology, 页码:6268-6282 , 文章类型: Article,,卷期:2009年29-23]
- In the 1970s, several human retinoblastoma cell lines were developed from cultures of primary tumors. As the human retinoblastoma cell lines were established in culture, growth properties and changes in cell adhesion wer...
- Hepatocyte Nuclear Factor 4 alpha, a Key Factor for Homeostasis, Cell Architecture, and Barrier Function of the Adult Intestinal Epithelium
[作者:Cattin, AL; Le Beyec, J; Barreau, F; Saint-Just, S; Houllier, A; Gonzalez, FJ; Robine, S; Pincon-Raymond, M; Cardot, P; Lacasa, M; Ribeiro, A,期刊:Molecular and Cellular Biology, 页码:6294-6308 , 文章类型: Article,,卷期:2009年29-23]
- Hepatocyte nuclear factor 4 alpha (HNF-4 alpha) is a transcription factor which is highly expressed in the intestinal epithelium from duodenum to colon and from crypt to villus. The homeostasis of this constantly renewin...
- Crucial Role for Mst1 and Mst2 Kinases in Early Embryonic Development of the Mouse
[作者:Oh, S; Lee, D; Kim, T; Kim, TS; Oh, HJ; Hwang, CY; Kong, YY; Kwon, KS; Lim, DS,期刊:Molecular and Cellular Biology, 页码:6309-6320 , 文章类型: Article,,卷期:2009年29-23]
- Mammalian sterile 20-like kinases 1 and 2 (Mst1 and Mst2, respectively) are potent serine/threonine kinases that are involved in cell proliferation and cell death. To investigate the physiological functions of Mst1 and M...
- Peroxisome Proliferator-Activated Receptor beta/delta (PPAR beta/delta) but Not PPAR alpha Serves as a Plasma Free Fatty Acid Sensor in Liver
[作者:Sanderson, LM; Degenhardt, T; Koppen, A; Kalkhoven, E; Desvergne, B; Muller, M; Kersten, S,期刊:Molecular and Cellular Biology, 页码:6257-6267 , 文章类型: Article,,卷期:2009年29-23]
- Peroxisome proliferator-activated receptor alpha (PPAR alpha) is an important transcription factor in liver that can be activated physiologically by fasting or pharmacologically by using high-affinity synthetic agonists....
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