- Thoc1 Deficiency Compromises Gene Expression Necessary for Normal Testis Development in the Mouse
[作者:Wang, XL; Chinnam, M; Wang, JM; Wang, YQ; Zhang, XJ; Marcon, E; Moens, P; Goodrich, DW,期刊:Molecular and Cellular Biology, 页码:2794-2803 , 文章类型: Article,,卷期:2009年29-10]
- Accumulating evidence suggests that regulation of RNA processing through an RNP-driven mechanism is important for coordinated gene expression. This hypothesis predicts that defects in RNP biogenesis will adversely affect...
- The p53 Tumor Suppressor Causes Congenital Malformations in Rpl24-Deficient Mice and Promotes Their Survival
[作者:Barkic, M; Crnomarkovic, S; Grabusic, K; Bogetic, I; Panic, L; Tamarut, S; Cokaric, M; Jeric, I; Vidak, S; Volarevic, S,期刊:Molecular and Cellular Biology, 页码:2489-2504 , 文章类型: Article,,卷期:2009年29-10]
- Hypomorphic mutation in one allele of ribosomal protein l24 gene (Rpl24) is responsible for the Belly Spot and Tail (Bst) mouse, which suffers from defects of the eye, skeleton, and coat pigmentation. It has been hypothe...
- Zinc Finger Protein Zbtb20 Is Essential for Postnatal Survival and Glucose Homeostasis
[作者:Sutherland, APR; Zhang, H; Zhang, Y; Michaud, M; Xie, ZF; Patti, ME; Grusby, MJ; Zhang, WJ,期刊:Molecular and Cellular Biology, 页码:2804-2815 , 文章类型: Article,,卷期:2009年29-10]
- Zbtb20 is a member of the POK family of proteins, which function primarily as transcriptional repressors via interactions mediated by their conserved C2H2 Kruppel type zinc finger and BTB/POZ domains. To define the funct...
- Spi-1 and Fli-1 Directly Activate Common Target Genes Involved in Ribosome Biogenesis in Friend Erythroleukemic Cells
[作者:Juban, G; Giraud, G; Guyot, B; Belin, S; Diaz, JJ; Starck, J; Guillouf, C; Moreau-Gachelin, F; Morle, F,期刊:Molecular and Cellular Biology, 页码:2852-2864 , 文章类型: Article,,卷期:2009年29-10]
- Spi-1 and Fli-1 are ETS transcription factors recurrently deregulated in mouse erythroleukemia induced by Friend viruses. Since they share the same core DNA binding site, we investigated whether they may contribute to er...
- Tyrosine Phosphorylation of Grb2: Role in Prolactin/Epidermal Growth Factor Cross Talk in Mammary Epithelial Cell Growth and Differentiation
[作者:Haines, E; Minoo, P; Feng, Z; Resalatpanah, N; Nie, XM; Campiglio, M; Alvarez, L; Cocolakis, E; Ridha, M; Di Fulvio, M; Gomez-Cambronero, J; Lebrun, JJ; Ali, S,期刊:Molecular and Cellular Biology, 页码:2505-2520 , 文章类型: Article,,卷期:2009年29-10]
- Characterizing mechanisms regulating mammary cell growth and differentiation is vital, as they may contribute to breast carcinogenesis. Here, we examine a cross talk mechanism(s) downstream of prolactin (PRL), a primary ...
- Direct Spatial Control of Epac1 by Cyclic AMP
[作者:Ponsioen, B; Gloerich, M; Ritsma, L; Rehmann, H; Bos, JL; Jalink, K,期刊:Molecular and Cellular Biology, 页码:2521-2531 , 文章类型: Article,,卷期:2009年29-10]
- Epac1 is a guanine nucleotide exchange factor (GEF) for the small G protein Rap and is directly activated by cyclic AMP (cAMP). Upon cAMP binding, Epac1 undergoes a conformational change that allows the interaction of it...
- Mutational Analysis of the Sir3 BAH Domain Reveals Multiple Points of Interaction with Nucleosomes
[作者:Sampath, V; Yuan, P; Wang, IX; Prugar, E; van Leeuwen, F; Sternglanz, R,期刊:Molecular and Cellular Biology, 页码:2532-2545 , 文章类型: Article,,卷期:2009年29-10]
- Sir3, a component of the transcriptional silencing complex in the yeast Saccharomyces cerevisiae, has an N-terminal BAH domain that is crucial for the protein's silencing function. Previous work has shown that the N-term...
- Regulation of p53 by TopBP1: a Potential Mechanism for p53 Inactivation in Cancer
[作者:Liu, K; Bellam, N; Lin, HY; Wang, B; Stockard, CR; Grizzle, WE; Lin, WC,期刊:Molecular and Cellular Biology, 页码:2673-2693 , 文章类型: Article,,卷期:2009年29-10]
- Proper control of the G(1)/S checkpoint is essential for normal proliferation. The activity of p53 must be kept at a very low level under unstressed conditions to allow growth. Here we provide evidence supporting a cruci...
- ADAM9 Is Involved in Pathological Retinal Neovascularization
[作者:Guaiquil, V; Swendeman, S; Yoshida, T; Chavala, S; Campochiaro, PA; Blobel, CP,期刊:Molecular and Cellular Biology, 页码:2694-2703 , 文章类型: Article,,卷期:2009年29-10]
- Pathological ocular neovascularization, caused by diabetic retinopathy, age-related macular degeneration, or retinopathy of prematurity, is a leading cause of blindness, yet much remains to be learned about its underlyin...
- Interferon-Dependent Engagement of Eukaryotic Initiation Factor 4B via S6 Kinase (S6K)-and Ribosomal Protein S6K-Mediated Signals
[作者:Kroczynska, B; Kaur, S; Katsoulidis, E; Majchrzak-Kita, B; Sassano, A; Kozma, SC; Fish, EN; Platanias, LC,期刊:Molecular and Cellular Biology, 页码:2865-2875 , 文章类型: Article,,卷期:2009年29-10]
- Although the roles of Jak-Stat pathways in type I and II interferon (IFN)-dependent transcriptional regulation are well established, the precise mechanisms of mRNA translation for IFN-sensitive genes remain to be defined...
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