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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共20条记录   Probing Fibril Dissolution of the Repeat Domain of a Functional Amyloid, Pmel17, on the Microscopic and Residue Level [作者：McGlinchey, RP; Gruschus, JM; Nagy, A; Lee, JC,期刊：Biochemistry, 页码：10567-10569 , 文章类型： Article，,卷期：2011年50-49] Pmel17 is a human amyloid involved in melanin synthesis. A fragment of Pmel17, the repeat domain (RPT) rich in glutamic acids, forms amyloid only at mildly acidic pH. Unlike pathological amyloids, these fibrils dissolve ... Lipopolysaccharide Biosynthesis without the Lipids: Recognition Promiscuity of Escherichia coli Heptosyltransferase I [作者：Czyzyk, DJ; Liu, C; Taylor, EA,期刊：Biochemistry, 页码：10570-10572 , 文章类型： Article，,卷期：2011年50-49] Heptosyltransferase I (HepI) is responsible for the transfer of L-glycero-D-manno-heptose to a 3-deoxy-alpha-D-oct-2-ulopyranosonic acid (Kdo) of the growing core region of lipopolysaccharide (LPS). The catalytic efficie... Pyruvate Is the Source of the Two Carbons That Are Required for Formation of the Imidazoline Ring of 4-Demethylwyosine [作者：Young, AP; Bandarian, V,期刊：Biochemistry, 页码：10573-10575 , 文章类型： Article，,卷期：2011年50-49] TYW1 catalyzes the condensation of N-methylguanosine with two carbon atoms from an unknown second substrate to form 4-demethylwyosine, which is a common intermediate in the biosynthesis of all of the hypermodified RNA ba... Branched Intermediate Formation Is the Slowest Step in the Protein Splicing Reaction of the Ala1 KlbA Intein from Methanococcus jannaschii [作者：Saleh, L; Southworth, MW; Considine, N; O'Neill, C; Benner, J; Bollinger, JM; Perler, FB,期刊：Biochemistry, 页码：10576-10589 , 文章类型： Article，,卷期：2011年50-49] We report the first detailed investigation of the kinetics of protein splicing by the Methanococcus jannaschii KlbA (Mja KlbA) intein. This intein has an N-terminal Ala in place of the nucleophilic Cys or Ser residue tha... A Native Disulfide Stabilizes Non-Native Helical Structures in Partially Folded States of Equine beta-Lactoglobulin [作者：Yamamoto, M; Nakagawa, K; Fujiwara, K; Shimizu, A; Ikeguchi, M; Ikeguchi, M,期刊：Biochemistry, 页码：10590-10597 , 文章类型： Article，,卷期：2011年50-49] Equine beta-lactoglobulin (ELG) assumes non-native helices during refolding and in partially folded states. Previously, circular dichroism (CD) combined with site-directed mutagenesis identified helical regions in the ac... Reconstitution of the Platelet Glycoprotein Ib-IX Complex in Phospholipid Bilayer Nanodiscs [作者：Yan, R; Mo, X; Paredes, AM; Dai, KS; Lanza, F; Cruz, MA; Li, RH,期刊：Biochemistry, 页码：10598-10606 , 文章类型： Article，,卷期：2011年50-49] The glycoprotein Ib-IX (GPIb-IX) complex expressed on platelet plasma membrane is involved in thrombosis and hemostasis via the initiation of adhesion of platelets to von Willebrand factor (VWF) exposed at the injured ve... Does the Crowded Cell-like Environment Reduce the Chaperone-like Activity of alpha-Crystallin? [作者：Roman, SG; Chebotareva, NA; Eronina, TB; Kleymenov, SY; Makeeva, VF; Poliansky, NB; Muranov, KO; Kurganov, BI,期刊：Biochemistry, 页码：10607-10623 , 文章类型： Article，,卷期：2011年50-49] The effect of crowding on the chaperone-like activity of alpha-crystallin has been studied using aggregation of UV-irradiated glycogen phosphorylase b (Phb) from rabbit skeletal muscle as an aggregation test system. The ... Black Tea Theaflavins Inhibit Formation of Toxic Amyloid-beta and alpha-Synuclein Fibrils [作者：Grelle, G; Otto, A; Lorenz, M; Frank, RF; Wanker, EE; Bieschke, J,期刊：Biochemistry, 页码：10624-10636 , 文章类型： Article，,卷期：2011年50-49] Causal therapeutic approaches for amyloid diseases such as Alzheimer's and Parkinson's disease targeting toxic amyloid oligomers or fibrils are still emerging. Here, we show that theaflavins (TF1, TF2a, TF2b, and TF3), t... Slow Motions in the Hydrophobic Core of Chicken Villin Headpiece Subdomain and Their Contributions to Configurational Entropy and Heat Capacity from Solid-State Deuteron NMR Measurements [作者：Vugmeyster, L; Ostroysky, D; Khadjinoya, A; Ellden, J; Hoatson, GL; Vold, RL,期刊：Biochemistry, 页码：10637-10646 , 文章类型： Article，,卷期：2011年50-49] We have investigated microsecond to millisecond time scale dynamics in several key hydrophobic core methyl groups of chicken villin headpiece subdomain protein (HP36) using a combination of single-site labeling, deuteron... Binding of 3,4,5,6-Tetrahydroxyazepanes to the Acid-beta-glucosidase Active Site: Implications for Pharmacological Chaperone Design for Gaucher Disease [作者：Orwig, SD; Tan, YL; Grimster, NP; Yu, ZQ; Powers, ET; Kelly, JW; Lieberman, RL,期刊：Biochemistry, 页码：10647-10657 , 文章类型： Article，,卷期：2011年50-49] Pharmacologic chaperoning is a therapeutic strategy being developed to improve the cellular folding and trafficking defects associated with Gaucher disease, a lysosomal storage disorder caused by point mutations in the g... Photoproduction of Catalase-Insensitive Peroxides on the Donor Side of Manganese-Depleted Photosystem II: Evidence with a Specific Fluorescent Probe [作者：Khorobrykh, SA; Khorobrykh, AA; Yanykin, DV; Ivanov, BN; Klimov, VV; Mano, J,期刊：Biochemistry, 页码：10658-10665 , 文章类型： Article，,卷期：2011年50-49] The photoproduction of organic peroxides (ROOH) in photosystem II (PSII) membranes was studied using the fluorescent probe Spy-HP. Two types of peroxide, highly lipophilic ones and relatively hydrophilic ones, were disti... Metal Selectivity of the Escherichia coli Nickel Metallochaperone, SlyD [作者：Kaluarachchi, H; Siebel, JF; Kaluarachchi-Duffy, S; Krecisz, S; Sutherland, DEK; Stillman, MJ; Zamble, DB,期刊：Biochemistry, 页码：10666-10677 , 文章类型： Article，,卷期：2011年50-49] SlyD is a Ni(II)-binding protein that contributes to nickel homeostasis in Escherichia coli. The C-terminal I domain of SlyD contains a rich variety of metal-binding amino acids, suggesting broader metal binding capabili... Substrate Recognition by beta-Ketoacyl-ACP Synthases [作者：Borgaro, JG; Chang, A; Machutta, CA; Zhang, XJ; Tonge, PJ,期刊：Biochemistry, 页码：10678-10686 , 文章类型： Article，,卷期：2011年50-49] beta-Ketoacyl-ACP synthase (KAS) enzymes catalyze Claisen condensation reactions in the fatty acid biosynthesis pathway. These reactions follow a ping-pong mechanism in which a donor substrate acylates the active site cy... Induction of Methionine-Sulfoxide Reductases Protects Neurons from Amyloid beta-Protein Insults in Vitro and in Vivo [作者：Moskovitz, J; Maiti, P; Lopes, DHJ; Oien, DB; Attar, A; Liu, TY; Mittal, S; Hayes, J; Bitan, G,期刊：Biochemistry, 页码：10687-10697 , 文章类型： Article，,卷期：2011年50-49] Self-assembly of amyloid beta-protein (A beta) into toxic oligomers and fibrillar polymers is believed to cause Alzheimer's disease (AD). In the AD brain, a high percentage of A beta contains Met-sulfoxide at position 35... Rational and Computational Design of Stabilized Variants of Cyanovirin-N That Retain Affinity and Specificity for Glycan Ligands [作者：Patsalo, V; Raleigh, DP; Green, DF,期刊：Biochemistry, 页码：10698-10712 , 文章类型： Article，,卷期：2011年50-49] Cyanovirin-N (CVN) is an 11 kDa pseudosymmetric cyanobacterial lectin that has been shown to inhibit infection by the human immunodeficiency virus by binding to high-mannose oligosaccharides on the surface of the viral e... Importance of the C2, N7, and C8 Positions to the Mutagenic Potential of 8-Oxo-2 '-deoxyguanosine with Two A Family Polymerases [作者：Hamm, ML; Crowley, KA; Ghio, M; Del Giorno, L; Gustafson, MA; Kindler, KE; Ligon, CW; Lindell, MAM; McFadden, EJ; Siekavizza-Robles, C; Summers, MR,期刊：Biochemistry, 页码：10713-10723 , 文章类型： Article，,卷期：2011年50-49] 8-Oxo-2'-deoxyguanosine (OdG) is a prominent DNA lesion produced from the reaction of 2'-deoxyguanosine (dG) with reactive oxygen species. While dG directs the insertion of only dCTP during replication, OdG can direct th...