- Origin of first cells at terrestrial, anoxic geothermal fields
[作者:Mulkidjanian, AY; Bychkov, AY; Dibrova, DV; Galperin, MY; Koonin, EV,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E821-E830 , 文章类型: Article,,卷期:2012年109-14]
- All cells contain much more potassium, phosphate, and transition metals than modern (or reconstructed primeval) oceans, lakes, or rivers. Cells maintain ion gradients by using sophisticated, energy-dependent membrane enz...
- Serotonin transporter polyadenylation polymorphism modulates the retention of fear extinction memory
[作者:Hartley, CA; McKenna, MC; Salman, R; Holmes, A; Casey, BJ; Phelps, EA; Glatt, CE,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5493-5498 , 文章类型: Article,,卷期:2012年109-14]
- Growing evidence suggests serotonin's role in anxiety and depression is mediated by its effects on learned fear associations. Pharmacological and genetic manipulations of serotonin signaling in mice alter the retention o...
- Autism gene variant causes hyperserotonemia, serotonin receptor hypersensitivity, social impairment and repetitive behavior
[作者:Veenstra-VanderWeele, J; Muller, CL; Iwamoto, H; Sauer, JE; Owens, WA; Shah, CR; Cohen, J; Mannangatti, P; Jessen, T; Thompson, BJ; Ye, R; Kerr, TM; Carneiro, AM; Crawley, JN; Sanders-Bush, E; McMahon, DG; Ramamoorthy, S; Daws, LC; Sutcliffe, JS; Blakely, RD,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5469-5474 , 文章类型: Article,,卷期:2012年109-14]
- Fifty years ago, increased whole-blood serotonin levels, or hyperserotonemia, first linked disrupted 5-HT homeostasis to Autism Spectrum Disorders (ASDs). The 5-HT transporter (SERT) gene (SLC6A4) has been associated wit...
- Lantibiotics from Geobacillus thermodenitrificans
[作者:Garg, N; Tang, WX; Goto, Y; Nair, SK; van der Donk, WA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5241-5246 , 文章类型: Article,,卷期:2012年109-14]
- The lantibiotic nisin has been used as an effective food preservative to combat food-borne pathogens for over 40 y. Despite this successful use, nisin's stability at pH 7 is limited. Herein, we describe a nisin analog en...
- Partially collapsed cristobalite structure in the non molecular phase V in CO2
[作者:Santoro, M; Gorelli, FA; Bini, R; Haines, J; Cambon, O; Levelut, C; Montoya, JA; Scandolo, S,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5176-5179 , 文章类型: Article,,卷期:2012年109-14]
- Non molecular CO2 has been an important subject of study in high pressure physics and chemistry for the past decade opening up a unique area of carbon chemistry. The phase diagram of CO2 includes several non molecular ph...
- The Williams syndrome chromosome 7q11.23 hemideletion confers hypersocial, anxious personality coupled with altered insula structure and function
[作者:Jabbi, M; Kippenhan, JS; Kohn, P; Marenco, S; Mervis, CB; Morris, CA; Meyer-Lindenberg, A; Berman, KF,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E860-E866 , 文章类型: Article,,卷期:2012年109-14]
- Although it is widely accepted that genes can influence complex behavioral traits such as human temperament, the underlying neurogenetic mechanisms remain unclear. Williams syndrome (WS), a rare disorder caused by a hemi...
- Genome-wide analysis of histone H3.1 and H3.3 variants in Arabidopsis thaliana
[作者:Stroud, H; Otero, S; Desvoyes, B; Ramirez-Parra, E; Jacobsen, SE; Gutierrez, C,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5370-5375 , 文章类型: Article,,卷期:2012年109-14]
- Nucleosomes package eukaryotic DNA and are composed of four different histone proteins, designated H3, H4, H2A, and H2B. Histone H3 has two main variants, H3.1 and H3.3, which show different genomic localization patterns...
- Lipid-derived nanoparticles for immunostimulatory RNA adjuvant delivery
[作者:Nguyen, DN; Mahon, KP; Chikh, G; Kim, P; Chung, H; Vicari, AP; Love, KT; Goldberg, M; Chen, S; Krieg, AM; Chen, JZ; Langer, R; Anderson, DG,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E797-E803 , 文章类型: Article,,卷期:2012年109-14]
- The specific activation of Toll-like receptors (TLRs) has potential utility for a variety of therapeutic indications including antiviral immunotherapy and as vaccine adjuvants. TLR7 and TLR 8 may be activated by their na...
- Mechanism for Burgess Shale-type preservation
[作者:Gaines, RR; Hammarlund, EU; Hou, XG; Qi, CS; Gabbott, SE; Zhao, YL; Peng, J; Canfield, DE,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5180-5184 , 文章类型: Article,,卷期:2012年109-14]
- Exceptionally preserved fossil biotas of the Burgess Shale and a handful of other similar Cambrian deposits provide rare but critical insights into the early diversification of animals. The extraordinary preservation of ...
- Time-lapse two-color 3D imaging of live cells with doubled resolution using structured illumination
[作者:Fiolka, R; Shao, L; Rego, EH; Davidson, MW; Gustafsson, MGL,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5311-5315 , 文章类型: Article,,卷期:2012年109-14]
- Previous implementations of structured-illumination microscopy (SIM) were slow or designed for one-color excitation, sacrificing two unique and extremely beneficial aspects of light microscopy: live-cell imaging in multi...
- Direct observation of multiple misfolding pathways in a single prion protein molecule
[作者:Yu, H; Liu, X; Neupane, K; Gupta, AN; Brigley, AM; Solanki, A; Sosova, I; Woodside, MT,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5283-5288 , 文章类型: Article,,卷期:2012年109-14]
- Protein misfolding is a ubiquitous phenomenon associated with a wide range of diseases. Single-molecule approaches offer a powerful tool for deciphering the mechanisms of misfolding by measuring the conformational fluctu...
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