- Transcription and mRNA Stability: Parental Guidance Suggested
[作者：Bellofatto, V; Wilusz, J,期刊：Cell, 页码：1438-1439 , 文章类型： Editorial Material，,卷期：2011年147-7]
- The level of an mRNA within a cell depends on both its rate of synthesis and rate of decay. Now, independent studies by Bregman et al. and Trcek et al. provide evidence that these two processes are integrated. They show ...
- Learning to Protect Your Genome on the Fly
[作者：Levine, MT; Malik, HS,期刊：Cell, 页码：1440-1441 , 文章类型： Editorial Material，,卷期：2011年147-7]
- Piwi-interacting RNAs (piRNAs) help defend host genomes against germline transposons. In this issue of Cell, Khurana et al. show how alterations in the piRNA-encoding loci within a single generation allow a naive fly gen...
- Metabolic Connections during Apoptotic Cell Engulfment
[作者：Han, CZ; Ravichandran, KS,期刊：Cell, 页码：1442-1445 , 文章类型： Review，,卷期：2011年147-7]
- Billions of cells die via apoptosis every day and are swiftly removed. When a phagocyte engulfs an apoptotic cell, it essentially doubles its cellular contents, raising the question of how a phagocyte may manage the exce...
- The Microbial Opsin Family of Optogenetic Tools
[作者：Zhang, F; Vierock, J; Yizhar, O; Fenno, LE; Tsunoda, S; Kianianmomeni, A; Prigge, M; Berndt, A; Cushman, J; Polle, J; Magnuson, J; Hegemann, P; Deisseroth, K,期刊：Cell, 页码：1446-1457 , 文章类型： Article，,卷期：2011年147-7]
- The capture and utilization of light is an exquisitely evolved process. The single-component microbial opsins, although more limited than multicomponent cascades in processing, display unparalleled compactness and speed....
- SIRT1 Activates MAO-A in the Brain to Mediate Anxiety and Exploratory Drive
[作者：Libert, S; Pointer, K; Bell, EL; Das, A; Cohen, DE; Asara, JM; Kapur, K; Bergmann, S; Preisig, M; Otowa, T; Kendler, KS; Chen, XN; Hettema, JM; van den Oord, EJ; Rubio, JP; Guarente, L,期刊：Cell, 页码：1459-1472 , 文章类型： Article，,卷期：2011年147-7]
- SIRT1 is a NAD(+)-dependent deacetylase that governs a number of genetic programs to cope with changes in the nutritional status of cells and organisms. Behavioral responses to food abundance are important for the surviv...
- Promoter Elements Regulate Cytoplasmic mRNA Decay
[作者：Bregman, A; Avraham-Kelbert, M; Barkai, O; Duek, L; Guterman, A; Choder, M,期刊：Cell, 页码：1473-1483 , 文章类型： Article，,卷期：2011年147-7]
- Promoters are DNA elements that enable transcription and its regulation by trans-acting factors. Here, we demonstrate that yeast promoters can also regulate mRNA decay after the mRNA leaves the nucleus. A conventional ye...
- Single-Molecule mRNA Decay Measurements Reveal Promoter-Regulated mRNA Stability in Yeast
[作者：Trcek, T; Larson, DR; Moldon, A; Query, CC; Singer, RH,期刊：Cell, 页码：1484-1497 , 文章类型： Article，,卷期：2011年147-7]
- Messenger RNA decay measurements are typically performed on a population of cells. However, this approach cannot reveal sufficient complexity to provide information on mechanisms that may regulate mRNA degradation, possi...
- Mbd3/NURD Complex Regulates Expression of 5-Hydroxymethylcytosine Marked Genes in Embryonic Stem Cells
[作者：Yildirim, O; Li, RW; Hung, JH; Chen, PB; Dong, XJ; Ee, LS; Weng, ZP; Rando, OJ; Fazzio, TG,期刊：Cell, 页码：1498-1510 , 文章类型： Article，,卷期：2011年147-7]
- Numerous chromatin regulators are required for embryonic stem (ES) cell self-renewal and pluripotency, but few have been studied in detail. Here, we examine the roles of several chromatin regulators whose loss affects th...
- A Poised Chromatin Platform for TGF-beta Access to Master Regulators
[作者：Xi, QR; Wang, ZX; Zaromytidou, AI; Zhang, XHF; Chow-Tsang, LF; Liu, JX; Kim, H; Barlas, A; Manova-Todorova, K; Kaartinen, V; Studer, L; Mark, W; Patel, DJ; Massague, J,期刊：Cell, 页码：1511-1524 , 文章类型： Article，,卷期：2011年147-7]
- Specific chromatin marks keep master regulators of differentiation silent yet poised for activation by extracellular signals. We report that nodal TGF-beta signals use the poised histone mark H3K9me3 to trigger different...
- Conserved Function of lincRNAs in Vertebrate Embryonic Development despite Rapid Sequence Evolution
[作者：Ulitsky, I; Shkumatava, A; Jan, CH; Sive, H; Bartel, DP,期刊：Cell, 页码：1537-1550 , 文章类型： Article，,卷期：2011年147-7]
- Thousands of long intervening noncoding RNAs (lincRNAs) have been identified in mammals. To better understand the evolution and functions of these enigmatic RNAs, we used chromatin marks, poly(A)-site mapping and RNA-Seq...
- Adaptation to P Element Transposon Invasion in Drosophila melanogaster
[作者：Khurana, JS; Wang, J; Xu, J; Koppetsch, BS; Thomson, TC; Nowosielska, A; Li, CJ; Zamore, PD; Weng, ZP; Theurkauf, WE,期刊：Cell, 页码：1551-1563 , 文章类型： Article，,卷期：2011年147-7]
- Transposons evolve rapidly and can mobilize and trigger genetic instability. Piwi-interacting RNAs (piRNAs) silence these genome pathogens, but it is unclear how the piRNA pathway adapts to invasion of new transposons. I...
- Hot Spots for Allosteric Regulation on Protein Surfaces
[作者：Reynolds, KA; McLaughlin, RN; Ranganathan, R,期刊：Cell, 页码：1564-1575 , 文章类型： Article，,卷期：2011年147-7]
- Recent work indicates a general architecture for proteins in which sparse networks of physically contiguous and coevolving amino acids underlie basic aspects of structure and function. These networks, termed sectors, are...
- Interaction between Differentiating Cell- and Niche-Derived Signals in Hematopoietic Progenitor Maintenance
[作者：Mondal, BC; Mukherjee, T; Mandal, L; Evans, CJ; Sinenko, SA; Martinez-Agosto, JA; Banerjee, U,期刊：Cell, 页码：1589-1600 , 文章类型： Article，,卷期：2011年147-7]
- Maintenance of a hematopoietic progenitor population requires extensive interaction with cells within a microenvironment or niche. In the Drosophila hematopoietic organ, niche-derived Hedgehog signaling maintains the pro...
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