- Structural insights into the peroxidase activity and inactivation of human peroxiredoxin 4
[作者:Wang, X; Wang, LK; Wang, X; Sun, F; Wang, CC,期刊:Biochemical Journal, 页码:113-118 , 文章类型: Article,,卷期:2012年441-1]
- Prx4 (peroxiredoxin 4) is the only peroxiredoxin located in the ER (endoplasmic reticulum) and a proposed scavenger for H(2)O(2). In the present study, we solved crystal structures of human Prx4 in three different redox ...
- Critical roles of RNA helicase DDX3 and its interactions with eIF4E/PABP1 in stress granule assembly and stress response
[作者:Shih, JW; Wang, WT; Tsai, TY; Kuo, CY; Li, HK; Lee, YHW,期刊:Biochemical Journal, 页码:119-129 , 文章类型: Article,,卷期:2012年441-1]
- Upon environmental insults, SGs (stress granules) aid cell survival by serving as sites of translational silencing. RNA helicase DDX3 was reported to associate with SGs. However, its role in SG physiology remains undefin...
- The high-resolution crystal structure of periplasmic Haemophilus influenzae NAD nucleotidase reveals a novel enzymatic function of human CD73 related to NAD metabolism
[作者:Garavaglia, S; Bruzzone, S; Cassani, C; Canella, L; Allegrone, G; Sturla, L; Mannino, E; Millo, E; De Flora, A; Rizzi, M,期刊:Biochemical Journal, 页码:131-141 , 文章类型: Article,,卷期:2012年441-1]
- Haemophilus influenzae is a major pathogen of the respiratory tract in humans that has developed the capability to exploit host NAD(P) for its nicotinamide dinucleotide requirement. This strategy is organized around a pe...
- Length of the active-site crossover loop defines the substrate specificity of ubiquitin C-terminal hydrolases for ubiquitin chains
[作者:Zhou, ZR; Zhang, YH; Liu, S; Song, AX; Hu, HY,期刊:Biochemical Journal, 页码:143-149 , 文章类型: Article,,卷期:2012年441-1]
- UCHs [Ub (ubiquitin) C-terminal hydrolases] are a family of deubiquitinating enzymes that are often thought to only remove small C-terminal peptide tails from Ub adducts. Among the four UCHs identified to date, neither U...
- Insights into subtle conformational differences in the substrate-binding loop of fungal 17 beta-hydroxysteroid dehydrogenase: a combined structural and kinetic approach
[作者:Cassetta, A; Krastanova, I; Kristan, K; Svegelj, MB; Lamba, D; Rizner, TL; Stojan, J,期刊:Biochemical Journal, 页码:151-160 , 文章类型: Article,,卷期:2012年441-1]
- The 17 beta-HSD (17 beta-hydroxysteroid dehydrogenase) from the filamentous fungus Cochliobolus lunatics (17 beta-HSDcl) is a NADP(H)-dependent enzyme that preferentially catalyses the interconversion of inactive 17-oxo-...
- A novel class of PTEN protein in Arabidopsis displays unusual phosphoinositide phosphatase activity and efficiently binds phosphatidic acid
[作者:Pribat, A; Sormani, R; Rousseau-Gueutin, M; Julkowska, MM; Testerink, C; Joubes, J; Castroviejo, M; Laguerre, M; Meyer, C; Germain, V; Rothan, C,期刊:Biochemical Journal, 页码:161-171 , 文章类型: Article,,卷期:2012年441-1]
- PTEN (phosphatase and tensin homologue deleted on chromosome ten) proteins are dual phosphatases with both protein and phosphoinositide phosphatase activity. They modulate signalling pathways controlling growth, metaboli...
- Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2
[作者:Krintel, C; Frydenvang, K; Olsen, L; Kristensen, MT; de Barrios, O; Naur, P; Francotte, P; Pirotte, B; Gajhede, M; Kastrup, JS,期刊:Biochemical Journal, 页码:173-178 , 文章类型: Article,,卷期:2012年441-1]
- Positive allosteric modulators of the ionotropic glutamate receptor-2 (GluA2) are promising compounds for the treatment of cognitive disorders, e.g. Alzheimer's disease. These modulators bind within the dimer interface o...
- Revealing the structural origin of the redox-Bohr effect: the first solution structure of a cytochrome from Geobacter sulfurreducens
[作者:Morgado, L; Paixao, VB; Schiffer, M; Pokkuluri, PR; Bruix, M; Salgueiro, CA,期刊:Biochemical Journal, 页码:179-187 , 文章类型: Article,,卷期:2012年441-1]
- Gs (Geobacter sulfurreducens) can transfer electrons to the exterior of its cells, a property that makes it a preferential candidate for the development of biotechnological applications. Its genome encodes over 100 cytoc...
- Vitamin E isoforms directly bind PKC alpha and differentially regulate activation of PKC alpha
[作者:McCary, CA; Yoon, Y; Panagabko, C; Cho, W; Atkinson, J; Cook-Mills, JM,期刊:Biochemical Journal, 页码:189-198 , 文章类型: Article,,卷期:2012年441-1]
- Vitamin E isoforms have opposing regulatory effects on leucocyte recruitment during inflammation. Furthermore, in vitro, vitamin E isoforms have opposing effects on leucocyte migration across endothelial cells by regulat...
- S6K inhibition renders cardiac protection against myocardial infarction through PDK1 phosphorylation of Akt
[作者:Di, RM; Wu, XQ; Chang, Z; Zhao, X; Feng, QT; Lu, SS; Luan, Q; Hemmings, BA; Li, XL; Yang, ZZ,期刊:Biochemical Journal, 页码:199-207 , 文章类型: Article,,卷期:2012年441-1]
- In the present study, we observed a rapid and robust activation of the ribosomal protein S6K (S6 kinase) provoked by MI (myocardial infarction) in mice. As activation of S6K promotes cell growth, we hypothesized that inc...
- Characterization of the cellular action of the MSK inhibitor SB-747651A
[作者:Naqvi, S; Macdonald, A; McCoy, CE; Darragh, J; Reith, AD; Arthur, JSC,期刊:Biochemical Journal, 页码:347-357 , 文章类型: Article,,卷期:2012年441-1]
- MSK1 (mitogen- and stress-activated kinase 1) and MSK2 are nuclear protein kinases that regulate transcription downstream of the ERK 1/2 (extracellular-signal-regulated kinase 1/2) and p38 alpha MAPKs (mitogen-activated ...
- Aldehyde stress and up-regulation of Nrf2-mediated antioxidant systems accompany functional adaptations in cardiac mitochondria from mice fed n-3 polyunsaturated fatty acids
[作者:Anderson, EJ; Thayne, K; Harris, M; Carraway, K; Shaikh, SR,期刊:Biochemical Journal, 页码:359-366 , 文章类型: Article,,卷期:2012年441-1]
- Diets replete with n-3 PUFAs (polyunsaturated fatty acids) are known to have therapeutic potential for the heart, although a specifically defined duration of the n-3 PUFA diet required to achieve these effects remains un...
- Adaptive evolution of drug targets in producer and non-producer organisms
[作者:Hansen, BG; Sun, XE; Genee, HJ; Kaas, CS; Nielsen, JB; Mortensen, UH; Frisvad, JC; Hedstrom, L,期刊:Biochemical Journal, 页码:219-226 , 文章类型: Article,,卷期:2012年441-1]
- MPA (mycophenolic acid) is an immunosuppressive drug produced by several fungi in Penicillium subgenus Penicillium. This toxic metabolite is an inhibitor of IMPDH (IMP dehydrogenase). The MPA-biosynthetic cluster of Peni...
- Targeted polyubiquitylation of RASSF1C by the Mule and SCF(beta-TrCP) ligases in response to DNA damage
[作者:Zhou, X; Li, TT; Feng, X; Hsiang, E; Xiong, Y; Guan, KL; Lei, QY,期刊:Biochemical Journal, 页码:227-236 , 文章类型: Article,,卷期:2012年441-1]
- RASSF1A [Ras association (RalGDS/AF-6) domain family member 1A] and RASSF1C are two ubiquitously expressed isoforms of the RASSF1 gene. The promoter of RASSF1A is frequently hypermethylated, resulting in inactivation in ...
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