- Activation of Insulin-Reactive CD8 T-Cells for Development of Autoimmune Diabetes
[作者：Wong, FS; Siew, LK; Scott, G; Thomas, IJ; Chapman, S; Viret, C; Wen, L,期刊：Diabetes, 页码：1156-1164 , 文章类型： Article，,卷期：2009年58-5]
- OBJECTIVE-We have previously reported a highly diabetogenic CD8 T-cell clone, G9C8, in the nonobese diabetic (NOD) mouse, specific to low-avidity insulin peptide B15-23, and cells responsive to this antigen are among the...
- Dynamic Changes in Pancreatic Endocrine Cell Abundance, Distribution, and Function in Antigen-Induced and Spontaneous Autoimmune Diabetes
[作者：Pechhold, K; Zhu, XL; Harrison, VS; Lee, J; Chakrabarty, S; Koczwara, K; Gavrilova, O; Harlan, DM,期刊：Diabetes, 页码：1175-1184 , 文章类型： Article，,卷期：2009年58-5]
- OBJECTIVE-Insulin deficiency in type 1 diabetes and in rodent autoimmune diabetes models is caused by beta-cell-specific killing by autoreactive T-cells. Less is known about beta-cell numbers and phenotype remaining at d...
- Muscle Microvascular Dysfunction in Central Obesity Is Related to Muscle Insulin Insensitivity but Is Not Reversed by High-Dose Statin Treatment
[作者：Clough, GF; Turzyniecka, M; Walter, L; Krentz, AJ; Wild, SH; Chipperfield, AJ; Gamble, J; Byrne, CD,期刊：Diabetes, 页码：1185-1191 , 文章类型： Proceedings Paper，,卷期：2009年58-5]
- OBJECTIVE-To test the hypotheses that decreased insulin-mediated glucose disposal in muscle is associated with a reduced muscle microvascular exchange capacity (K-f) and that 6 months of high-dose statin therapy would im...
- Accelerated Postnatal Growth Increases Lipogenic Gene Expression and Adipocyte Size in Low-Birth Weight Mice
[作者：Isganaitis, E; Jimenez-Chillaron, J; Woo, M; Chow, A; DeCoste, J; Vokes, M; Liu, MW; Kasif, S; Zavacki, AM; Leshan, RL; Myers, MG; Patti, ME,期刊：Diabetes, 页码：1192-1200 , 文章类型： Article，,卷期：2009年58-5]
- OBJECTIVE-To characterize the hormonal milieu and adipose gene expression in response to catch-up growth (CUG), a growth pattern associated with obesity and diabetes risk, in a mouse model of low birth weight (LBW). RESE...
- Mechanisms of Podocyte Injury in Diabetes Role of Cytochrome P450 and NADPH Oxidases
[作者：Eid, AA; Gorin, Y; Fagg, BM; Maalouf, R; Barnes, JL; Block, K; Abboud, HE,期刊：Diabetes, 页码：1201-1211 , 文章类型： Article，,卷期：2009年58-5]
- OBJECTIVE-We investigated the role of cytochrome P450 of the 4A family (CYP4A), its metabolites, and NADPH oxidases both in reactive oxygen species (ROS) production and apoptosis of podocytes exposed to high glucose and ...
- Changes in Insulin Sensitivity and Insulin Release in Relation to Glycemia and Glucose Tolerance in 6,414 Finnish Men
[作者：Stancakova, A; Javorsky, M; Kuttlasmaa, T; Haffner, SM; Kuusisto, J; Laakso, M,期刊：Diabetes, 页码：1212-1221 , 文章类型： Article，,卷期：2009年58-5]
- OBJECTIVE-We evaluated insulin sensitivity and insulin secretion across the entire range of fasting (FPG) and 2-h plasma glucose (PG), and we investigated the differences in insulin sensitivity and insulin release in dif...
- Specific Local Cardiovascular Changes of N-epsilon-(Carboxymethyl)lysine, Vascular Endothelial Growth Factor, and Smad2 in the Developing Embryos Coincide With Maternal Diabetes-Induced Congenital Heart Defects
[作者：Roest, PAM; Molin, DGM; Schalkwijk, CG; van Iperen, L; Wentzel, P; Eriksson, UJ; Gittenberger-de Groot, AC,期刊：Diabetes, 页码：1222-1228 , 文章类型： Proceedings Paper，,卷期：2009年58-5]
- OBJECTIVE-Embryos exposed to a diabetic environment in utero have an increased risk to develop congenital heart malformations. The mechanism behind the teratogenicity of diabetes still remains enigmatic. Detrimental effe...
- Hyperglycemia Induces a Dynamic Cooperativity of Histone Methylase and Demethylase Enzymes Associated With Gene-Activating Epigenetic Marks That Coexist on the Lysine Tail
[作者：Brasacchio, D; Okabe, J; Tikellis, C; Balcerczyk, A; George, P; Baker, EK; Calkin, AC; Brownlee, M; Cooper, ME; El-Osta, A,期刊：Diabetes, 页码：1229-1236 , 文章类型： Article，,卷期：2009年58-5]
- OBJECTIVE-Results from the Diabetes Control Complications Trial (DCCT) and the subsequent Epidemiology of Diabetes Interventions and Complications (EDIC) Study and more recently from the U.K. Prospective Diabetes Study (...
- Medium-Chain Fatty Acids Improve Cognitive Function in Intensively Treated Type 1 Diabetic Patients and Support In Vitro Synaptic Transmission During Acute Hypoglycemia
[作者：Page, KA; Williamson, A; Yu, NY; McNay, EC; Dzuira, J; McCrimmon, RJ; Sherwin, RS,期刊：Diabetes, 页码：1237-1244 , 文章类型： Proceedings Paper，,卷期：2009年58-5]
- OBJECTIVE-We examined whether ingestion of medium-chain triglycerides could improve cognition during hypoglycemia in subjects with intensively treated type 1 diabetes and assessed potential underlying mechanisms by testi...
- Functional Targets of the Monogenic Diabetes Transcription Factors HNF-1 alpha and HNF-4 alpha Are Highly Conserved Between Mice and Humans
[作者：Boj, SF; Servitja, JM; Martin, D; Rios, M; Talianidis, I; Guigo, R; Ferrer, J,期刊：Diabetes, 页码：1245-1253 , 文章类型： Article，,卷期：2009年58-5]
- OBJECTIVE-The evolutionary conservation of transcriptional mechanisms has been widely exploited to understand human biology and disease. Recent findings, however, unexpectedly showed that the transcriptional regulators h...
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