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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共12条记录   Relationship between plasma osteopontin and oxidative stress in patients with coronary artery disease [作者：Georgiadou, P; Iliodromitis, E; Varounis, C; Mavroidis, M; Kolokathis, F; Andreadou, I; Psarras, S; Capetanaki, Y; Boudoulas, H; Kremastinos, DT,期刊：Expert Opinion on Therapeutic Targets, 页码：917-920 , 文章类型： Article，,卷期：2008年12-8] Background: it is known that oxidative stress plays an important role in the pathogenesis of atherosclerosis and that an association exists between osteopontin (OPN) and atherosclerosis. Objectives: It was proposed that ... MK2: a novel molecular target for anti-inflammatory therapy [作者：Duraisamy, S; Bajpai, M; Bughani, U; Dastidar, SG; Ray, A; Chopra, P,期刊：Expert Opinion on Therapeutic Targets, 页码：921-936 , 文章类型： Review，,卷期：2008年12-8] Background: Mitogen-activated protein kinase (MAPK)-activated protein kinase 2 (MK2) is activated upon stress by p38 MAPK. MK2 is stimulated in a wide range of inflammatory conditions and its catalytic activity is requir... Cholesterol ester transfer protein: a therapeutic target in atherosclerosis? [作者：Vourvouhaki, E; Dedoussis, GV,期刊：Expert Opinion on Therapeutic Targets, 页码：937-948 , 文章类型： Review，,卷期：2008年12-8] Background: CETP has an established role in the transport of cholesterol from the peripheral tissues to the liver for elimination. The fact that CETP was recognized as a target for raising high-density lipoprotein choles... Treatment of autism spectrum disorders: neurotransmitter signaling pathways involved in motivation and reward as therapeutic targets [作者：Walker, MA,期刊：Expert Opinion on Therapeutic Targets, 页码：949-967 , 文章类型： Review，,卷期：2008年12-8] Background: There is a growing body of literature describing the etiology of autism spectrum disorders (ASD). Some of the targets suggested belong to neurochemical transmitter pathways implicated in the behavior and moti... Signaling through CD80: an approach for treating lymphomas [作者：Mir, MA; Agrewala, JN,期刊：Expert Opinion on Therapeutic Targets, 页码：969-979 , 文章类型： Review，,卷期：2008年12-8] Background: One of the mechanisms by which tumors evade the immune system is by downregulating the expression of costimulatory molecules like CD80 and CD86. The role of CD80 in the activation of T cells is well establish... IAPs as therapeutic targets in haematological malignancies [作者：Langemeijer, SMC; de Graaf, AO; Jansen, JH,期刊：Expert Opinion on Therapeutic Targets, 页码：981-993 , 文章类型： Review，,卷期：2008年12-8] Background: Regulation of apoptosis is fundamental to maintain the balance between cell survival and cell death. Disruption of this process may have severe consequences, contributing to carcinogenesis. Therapeutic target... Netrin-1 and its receptors in tumour growth promotion [作者：Bernet, A; Fitamant, J,期刊：Expert Opinion on Therapeutic Targets, 页码：995-1007 , 文章类型： Review，,卷期：2008年12-8] Background: Netrin-1 belongs to a family of secreted proteins that act as migration and adhesion cues in the developing CNS and in a number of non-neural tissues. Netrin-1 is the ligand of deleted in colorectal cancer (D... Downregulating sphingosine kinase-1 for cancer therapy [作者：Cuvillier, O,期刊：Expert Opinion on Therapeutic Targets, 页码：1009-1020 , 文章类型： Review，,卷期：2008年12-8] Background: The sphingolipids ceramide and sphingosine 1-phosphate (S1P) are key regulators of cell death and proliferation. The subtle balance between their intracellular levels is governed mainly by sphingosine kinase-... Grb2 signaling in cell motility and cancer [作者：Giubellino, A; Burke, TR; Bottaro, DP,期刊：Expert Opinion on Therapeutic Targets, 页码：1021-1033 , 文章类型： Review，,卷期：2008年12-8] Background: Metastasis is the primary cause of death in most human cancers, and understanding the molecular mechanisms underpinning this multistep process is fundamental to identifying novel molecular targets and develop... DNA methylation: A promising target for the twenty-first century [作者：Abreu, PA; Dellamora-Orriz, G; Leao-Ferreira, LR; Gouveia, M; Braggio, E; Zalcberg, I; Santos, DO; Bourguinhon, S; Cabral, LM; Rodrigues, CR; Castro, HC,期刊：Expert Opinion on Therapeutic Targets, 页码：1035-1047 , 文章类型： Review，,卷期：2008年12-8] Back round: Over the last few years DNA methylation and its involvement in diseases such as cancer has become of great interest for applied research. Since reversal of aberrant DNA methylation may influence the behavior ... PPAR-gamma signaling pathway in placental development and function: A potential therapeutic target in the treatment of gestational diseases [作者：Giaginis, C; Spanopoulou, E; Theocharis, S,期刊：Expert Opinion on Therapeutic Targets, 页码：1049-1063 , 文章类型： Review，,卷期：2008年12-8] Background: PPAR-gamma is a target for the treatment of metabolic disorders, as Pioglitazone and Rosiglitazone are already used against type 2 diabetes. Pleiotropic functions, such as anti proliferative and anti-inflamma... Use of LHRH-agonists as adjuvant therapy for breast cancer [作者：Cuzick, J,期刊：Expert Opinion on Therapeutic Targets, 页码：1065-1071 , 文章类型： Editorial Material，,卷期：2008年12-8] Individual data was collected for 11,906 women in 16 randomised trials evaluating a luteinising-hormone-releasing hormone (LHRH) agonist either alone, as an addition to tamoxifen or chemotherapy or in place of chemothera...