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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共17条记录   Sensing Proteins through Nanopores: Fundamental to Applications [作者：OUKHALED ABDELGHANI; BACRI LAURENT; PASTORIZAGALLEGO MANUELA; BETTON JEANMICHEL; PELTA JUAN,期刊：ACS CHEMICAL BIOLOGY, 页码：1935-1949 , 文章类型： Review，,卷期：2012年7-12] Proteins subjected to an electric field and forced to pass through a nanopore induce blockades of ionic current that depend on the protein and nanopore characteristics and interactions between them. Recent advances in th... Rapidly Relocating Molecules Between Organelles to Manipulate Small GTPase Activity [作者：PHUA SIEW CHENG; POHLMEYER CHRISTOPHER; INOUE TAKANARI,期刊：ACS CHEMICAL BIOLOGY, 页码：1950-1955 , 文章类型： Article，,卷期：2012年7-12] Chemically inducible rapid manipulation of small GTPase activity has proven a powerful approach to dissect complex spatiotemporal signaling of these molecular switches. However, overexpression of these synthetic molecula... Enzymatic Synthesis of Dilactone Scaffold of Antimycins [作者：SANDY MORIAH; RUI ZHE; GALLAGHER JOE; ZHANG WENJUN,期刊：ACS CHEMICAL BIOLOGY, 页码：1956-1961 , 文章类型： Article，,卷期：2012年7-12] Antimycins are a family of natural products possessing outstanding biological activities and unique structures, which have intrigued chemists for over a half century. The antimycin structural skeleton is built on a nine-... Identification of Pim Kinases as Novel Targets for PJ34 with Confounding Effects in PARP Biology [作者：ANTOLIN ALBERT A; JALENCAS XAVIER; YELAMOS JOSE; MESTRES JORDI,期刊：ACS CHEMICAL BIOLOGY, 页码：1962-1967 , 文章类型： Article，,卷期：2012年7-12] Small molecules are widely used in chemical biology without complete knowledge of their target profile, at risk of deriving conclusions that ignore potential confounding effects from unknown off-target interactions. The ... A Simple, Highly Visual in Vivo Screen for Anaplastic Lymphoma Kinase Inhibitors [作者：RODRIGUES FREDERICO S L M; YANG XUEYAN; NIKAIDO MASATAKA; LIU QINGSONG; KELSH ROBERT N,期刊：ACS CHEMICAL BIOLOGY, 页码：1968-1974 , 文章类型： Article，,卷期：2012年7-12] Anaplastic lymphoma kinase (ALK) is an important drug target in many cancers, including lymphoma, neuroblastoma, and lung cancer. Here, we demonstrate proof-of-principle for a novel and inexpensive assay for ALK inhibito... Novel Selective Allosteric and Bitopic Ligands for the S1P(3) Receptor [作者：JO EUIJUNG; BHHATARAI BARUN; REPETTO EMANUELA; GUERRERO MIGUEL; RILEY SEAN; BROWN STEVEN J; KOHNO YASUSHI; ROBERTS EDWARD; SCHUERER STEPHAN C; ROSEN HUGH,期刊：ACS CHEMICAL BIOLOGY, 页码：1975-1983 , 文章类型： Article，,卷期：2012年7-12] Sphingosine 1-phosphate (S1P) is a lysophospholipid signaling molecule that regulates important biological functions, including lymphocyte trafficking and vascular development, by activating G protein-coupled receptors f... Rational Design of Bioactive, Modularly Assembled Aminoglycosides Targeting the RNA that Causes Myotonic Dystrophy Type 1 [作者：CHILDSDISNEY JESSICA L; PARKESH RAMAN; NAKAMORI MASAYUKI; THORNTON CHARLES A; DISNEY MATTHEW D,期刊：ACS CHEMICAL BIOLOGY, 页码：1984-1993 , 文章类型： Article，,卷期：2012年7-12] Myotonic dystrophy type 1 (DM1) is caused when an expanded r(CUG) repeat (r(CUG)(exp)) binds the RNA splicing regulator muscleblind-like 1 protein (MBNL1) as well as other proteins. Previously, we reported that modularly... Structural Basis of Functional Group Activation by Sulfotransferases in Complex Metabolic Pathways [作者：MCCARTHY JENNIFER GEHRET; EISMAN ELI B; KULKARNI SARANG; GERWICK LENA; GERWICK WILLIAM H; WIPF PETER; SHERMAN DAVID H; SMITH JANET L,期刊：ACS CHEMICAL BIOLOGY, 页码：1994-2003 , 文章类型： Article，,卷期：2012年7-12] Sulfated molecules with diverse functions are common in biology, but sulfonation as a method to activate a metabolite for chemical catalysis is rare. Catalytic activity was characterized and crystal structures were deter... Tracing Fatty Acid Metabolism by Click Chemistry [作者：THIELE CHRISTOPH; PAPAN CYRUS; HOELPER DOMINIK; KUSSEROW KALINA; GAEBLER ANNE; SCHOENE MARIO; PIOTROWITZ KIRA; LOHMANN DANIEL; SPANDL JOHANNA; STEVANOVIC ANA; SHEVCHENKO ANDREJ; KUERSCHNER LARS,期刊：ACS CHEMICAL BIOLOGY, 页码：2004-2011 , 文章类型： Article，,卷期：2012年7-12] Fatty acids are abundant constituents of all biological systems, and their metabolism is important for normal function at all levels of an organism. Aberrations in fatty acid metabolism are associated with pathological s... Metabotyping of the C. elegans sir-2.1 Mutant Using in Vivo Labeling and C-13-Heteronuclear Multidimensional NMR Metabolomics [作者：AN YONG JIN; XU WEN JUN; JIN XING; WEN HE; KIM HYESOOK; LEE JUNHO; PARK SUNGHYOUK,期刊：ACS CHEMICAL BIOLOGY, 页码：2012-2018 , 文章类型： Article，,卷期：2012年7-12] The roles of sir-2.1 in C. elegans lifespan extension have been subjects of recent public and academic debates. We applied an efficient workflow for in vivo C-13-labeling of C. elegans and C-13-heteronuclear NMR metabolo... Chemoproteomic Profiling Identifies Changes in DNA-PK as Markers of Early Dengue Virus Infection [作者：VETTER MICHAEL L; RODGERS MARY A; PATRICELLI MATTHEW P; YANG PRISCILLA L,期刊：ACS CHEMICAL BIOLOGY, 页码：2019-2026 , 文章类型： Article，,卷期：2012年7-12] Many cellular factors are regulated via mechanisms affecting protein conformation, localization, and function that may be undetected by most commonly used RNA- and protein-based profiling methods that monitor steady-stat... Specificity of the E1-E2-E3 Enzymatic Cascade for Ubiquitin C-Terminal Sequences Identified by Phage Display [作者：ZHAO BO; BHURIPANYO KARAN; SCHNEIDER JEFFREY; ZHANG KEYA; SCHINDELIN HERMANN; BOONE DAVID; YIN JUN,期刊：ACS CHEMICAL BIOLOGY, 页码：2027-2035 , 文章类型： Article，,卷期：2012年7-12] Ubiquitin (UB) is a protein modifier that regulates many essential cellular processes. To initiate protein modification by UB, the E1 enzyme activates the C-terminal carboxylate of UB to launch its transfer through the E... An ABC Transporter with Two Periplasmic Binding Proteins Involved in Iron Acquisition in Pseudomonas aeruginosa [作者：BRILLET KARL; RUFFENACH FRANK; ADAMS HENDRIK; JOURNET LAURE; GASSER VERONIQUE; HOEGY FRANCOISE; GUILLON LAURENT; HANNAUER MELISSA; PAGE ADELINE; SCHALK ISABELLE J,期刊：ACS CHEMICAL BIOLOGY, 页码：2036-2045 , 文章类型： Article，,卷期：2012年7-12] Pyoverdine I is the main siderophore secreted by Pseudomonas aeruginosa PAO1 to obtain access to iron. After extracellular iron chelation, pyoverdine-Fe uptake into the bacteria involves a specific outer-membrane transpo... Picosecond to Second Dynamics Reveals a Structural Transition in Clostridium botulinum NO-Sensor Triggered by the Activator BAY-41-2272 [作者：YOO BYUNGKUK; LAMARRE ISABELLE; RAPPAPORT FABRICE; NIOCHE PIERRE; RAMAN C S; MARTIN JEANLOUIS; NEGRERIE MICHEL,期刊：ACS CHEMICAL BIOLOGY, 页码：2046-2054 , 文章类型： Article，,卷期：2012年7-12] Soluble guanylate cyclase (sGC) is the mammalian endogenous nitric oxide (NO) receptor that synthesizes cGMP upon NO activation. In synergy with the artificial allosteric effector BAY 41-2272 (a lead compound for drug de... A HaloTag-Based Small Molecule Microarray Screening Methodology with Increased Sensitivity and Multiplex Capabilities [作者：NOBLIN DEVIN J; PAGE CHARLOTTE M; TAE HYUN SEOP; GAREISS PETER C; SCHNEEKLOTH JOHN S; CREWS CRAIG M,期刊：ACS CHEMICAL BIOLOGY, 页码：2055-2063 , 文章类型： Article，,卷期：2012年7-12] Small Molecule Microarrays (SMMs) represent a general platform for screening small molecule-protein interactions independent of functional inhibition of target proteins. In an effort to increase the scope and utility of ... Fragment Screening of GPCRs Using Biophysical Methods: Identification of Ligands of the Adenosine A(2A) Receptor with Novel Biological Activity [作者：CHEN DAN; ERREY JAMES C; HEITMAN LAURA H; MARSHALL FIONA H; IJZERMAN ADRIAAN P; SIEGAL GREGG,期刊：ACS CHEMICAL BIOLOGY, 页码：2064-2073 , 文章类型： Article，,卷期：2012年7-12] Fragment-based drug discovery (FBDD) has proven a powerful method to develop novel drugs with excellent oral bioavailability against challenging pharmaceutical targets such as protein-protein interaction targets. Very re...