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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共18条记录   Androgen Receptor Antagonism by Divalent Ethisterone Conjugates in Castrate-Resistant Prostate Cancer Cells [作者：LEVINE PAUL M; LEE EUGINE; GREENFIELD ALEX; BONNEAU RICHARD; LOGAN SUSAN K; GARABEDIAN MICHAEL J; KIRSHENBAUM KENT,期刊：ACS CHEMICAL BIOLOGY, 页码：1693-1701 , 文章类型： Article，,卷期：2012年7-10] Sustained treatment of prostate cancer with androgen receptor (AR) antagonists can evoke drug resistance, leading to castrate-resistant disease. Elevated activity of the AR is often associated with this highly aggressive... 2C-Methyl-D-erythritol 4-Phosphate Enhances and Sustains Cyclodiphosphate Synthase IspF Activity [作者：BITOK J KIPCHIRCHIR; MEYERS CAREN FREEL,期刊：ACS CHEMICAL BIOLOGY, 页码：1702-1710 , 文章类型： Article，,卷期：2012年7-10] There is significant progress toward understanding catalysis throughout the essential MEP pathway to isoprenoids in human pathogens; however, little is known about pathway regulation. The present study begins by testing ... A Small Molecule That Targets r(CGG)(exp) and Improves Defects in Fragile X-Associated Tremor Ataxia Syndrome [作者：DISNEY MATTHEW D; LIU BIAO; YANG WANGYONG; SELLIER CHANTAL; TUAN TRAN; CHARLETBERGUERAND NICOLAS; CHILDSDISNEY JESSICA L,期刊：ACS CHEMICAL BIOLOGY, 页码：1711-1718 , 文章类型： Article，,卷期：2012年7-10] The development of small molecule chemical probes or therapeutics that target RNA remains a significant challenge despite the great interest in such compounds. The most significant barrier to compound development is defi... Attenuation of Quorum Sensing in the Pathogen Acinetobacter baumannii Using Non-native N-Acyl Homoserine Lactones [作者：STACY DANIELLE M; WELSH MICHAEL A; RATHER PHILIP N; BLACKWELL HELEN E,期刊：ACS CHEMICAL BIOLOGY, 页码：1719-1728 , 文章类型： Article，,卷期：2012年7-10] Many bacterial pathogens use quorum sensing (QS) to control virulence. As a result, the development of methods to intercept QS has attracted significant interest as a potential anti-infective therapy. Acinetobacter bauma... Lectin-Array Blotting: Profiling Protein Glycosylation in Complex Mixtures [作者：ETXEBARRIA JUAN; CALVO JAVIER; MARTINLOMAS MANUEL; REICHARDT NIELSCHRISTIAN,期刊：ACS CHEMICAL BIOLOGY, 页码：1729-1737 , 文章类型： Article，,卷期：2012年7-10] By combining electrophoretic protein separation with lectin-array-based glycan profiling into a single experiment, we have developed a high-throughput method for the rapid analysis of protein glycosylation in biofluids. ... Ondansetron and Granisetron Binding Orientation in the 5-HT3 Receptor Determined by Unnatural Amino Acid Mutagenesis [作者：DUFFY NOAH H; LESTER HENRY A; DOUGHERTY DENNIS A,期刊：ACS CHEMICAL BIOLOGY, 页码：1738-1745 , 文章类型： Article，,卷期：2012年7-10] The serotonin type 3 receptor (5-HT3R) is a ligand-gated ion channel found in the central and peripheral nervous systems. The 5-HT3R is a therapeutic target, and the clinically available drugs ondansetron and granisetron... Selective Penicillin-Binding Protein Imaging Probes Reveal Substructure in Bacterial Cell Division [作者：KOCAOGLU OZDEN; CALVO REBECCA A; SHAM LOKTO; COZY LORALYN M; LANNING BRYAN R; FRANCIS SAMSON; WINKLER MALCOLM E; KEARNS DANIEL B; CARLSON ERIN E,期刊：ACS CHEMICAL BIOLOGY, 页码：1746-1753 , 文章类型： Article，,卷期：2012年7-10] The peptidoglycan cell wall is a common target for antibiotic therapy, but its structure and assembly are only partially understood. Peptidoglycan synthesis requires a suite of penicillin-binding proteins (PBPs), the ind... Design of a Candida albicans Disaccharide Conjugate Vaccine by Reverse Engineering a Protective Monoclonal Antibody [作者：BUNDLE DAVID R; NYCHOLAT CORWIN; COSTELLO CASEY; RENNIE ROBERT; LIPINSKI TOMASZ,期刊：ACS CHEMICAL BIOLOGY, 页码：1754-1763 , 文章类型： Article，,卷期：2012年7-10] A disaccharide-chicken serum albumin conjugate vaccine against Candida albicans infections has been developed by reverse engineering a protective monoclonal antibody, C3.1. The binding site of C3.1 binds short oligosacch... Catalytic Mechanisms and Biocatalytic Applications of Aspartate and Methylaspartate Ammonia Lyases [作者：DE VILLIERS MARIANNE; VEETIL VINOD PUTHAN; RAJ HANS; DE VILLIERS JANDRE; POELARENDS GERRIT J,期刊：ACS CHEMICAL BIOLOGY, 页码：1618-1628 , 文章类型： Review，,卷期：2012年7-10] Ammonia lyases catalyze the formation of alpha-beta-unsaturated bonds by the elimination of ammonia from their substrates. This conceptually straightforward reaction has been the emphasis of many studies, with the main f... Detection of Highly Curved Membrane Surfaces Using a Cyclic Peptide Derived from Synaptotagmin-I [作者：SALUDES JONEL P; MORTON LESLIE A; GHOSH NILANJAN; BENINSON LIDA A; CHAPMAN EDWIN R; FLESHNER MONIKA; YIN HANG,期刊：ACS CHEMICAL BIOLOGY, 页码：1629-1635 , 文章类型： Article，,卷期：2012年7-10] The generation of highly curved membranes is essential to cell growth, division, and movement. Recent research in the field is focused to answer questions related to the consequences of changes in the topology of the mem... New Sensors for Quantitative Measurement of Mitochondrial Zn2+ [作者：PARK J GENEVIEVE; QIN YAN; GALATI DOMENICO F; PALMER AMY E,期刊：ACS CHEMICAL BIOLOGY, 页码：1636-1640 , 文章类型： Article，,卷期：2012年7-10] Zinc (Zn2+) homeostasis plays a vital role in cell function, and the dysregulation of intracellular Zn2+ is associated with mitochondria] dysfunction. Few tools exist to quantitatively monitor the buffered, free Zn2+ con... Potentiation of the Kv1 Family K+ Channel by Cortisone Analogues [作者：PAN YAPING; LEVIN ELENA J; QUICK MATTHIAS; ZHOU MING,期刊：ACS CHEMICAL BIOLOGY, 页码：1641-1646 , 文章类型： Article，,卷期：2012年7-10] The Kv1 family voltage-dependent K+ channels are essential for termination of action potentials in neurons and myocytes. These channels form a stable complex with their beta subunits (Kv beta), some of which inhibit chan... Structure-Activity Relationship of a Broad-Spectrum Insect Odorant Receptor Agonist [作者：TAYLOR ROBERT W; ROMAINE IAN M; LIU CHAO; MURTHI POORNIMA; JONES PATRICK L; WATERSON ALEX G; SULIKOWSKI GARY A; ZWIEBEL LAURENCE J,期刊：ACS CHEMICAL BIOLOGY, 页码：1647-1652 , 文章类型： Article，,卷期：2012年7-10] Agonism of insect odorant receptor (OR) cation channels may represent a new strategy for the manipulation of destructive insect olfactory-driven behaviors. We have explored the chemical space around VUAA1, the first in c... Development of a Selective Activity-Based Probe for Adenylating Enzymes: Profiling MbtA Involved in Siderophore Biosynthesis from Mycobacterium tuberculosis [作者：DUCKWORTH BENJAMIN P; WILSON DANIEL J; NELSON KATHRYN M; BOSHOFF HELENA I; BARRY CLIFTON E III; ALDRICH COURTNEY C,期刊：ACS CHEMICAL BIOLOGY, 页码：1653-1658 , 文章类型： Article，,卷期：2012年7-10] MbtA is an adenylating enzyme from Mycobacterium tuberculosis that catalyzes the first step in the biosynthesis of the mycobactins. A bisubstrate inhibitor of MbtA (Sal-AMS) was previously described that displays potent ... A Rapid in Vivo Colorimetric Library Screen for Inhibitors of Microbial Respiration [作者：VALLIERES CINDY; FISHER NICHOLAS; LEMOINE MARC; PAMLARD OLIVIER; BEAUPIERRE SANDRA; GUILLOU CATHERINE; MEUNIER BRIGITTE,期刊：ACS CHEMICAL BIOLOGY, 页码：1659-1665 , 文章类型： Article，,卷期：2012年7-10] A number of fungicides that target the respiratory chain enzymes complexes H and III are used in agriculture. They are active against a large range of phytopathogens. Unfortunately, the evolution of fungicide resistance ... Isolation and Functional Characterization of Peptide Agonists of PTPRJ, a Tyrosine Phosphatase Receptor Endowed with Tumor Suppressor Activity [作者：PADUANO FRANCESCO; ORTUSO FRANCESCO; CAMPIGLIA PIETRO; RASO CINZIA; IACCINO ENRICO; GASPARI MARCO; GAUDIO EUGENIO; MANGONE GRAZIELLA; CAROTENUTO ALFONSO; BILOTTA ANNA; NARCISO DOMENICO; PALMIERI CAMILLO; AGOSTI VALTER; ARTESE ANNA; GOMEZMONTERREY ISABEL; SALA MARINA; CUDA GIOVANNI; IULIANO RODOLFO; PERROTTI NICOLA; SCALA GIUSEPPE; VIGLIETTO GIUSEPPE; ALCARO STEFANO; CROCE CARLO M; NOVELLINO ETTORE; FUSCO ALFREDO; TRAPASSO FRANCESCO,期刊：ACS CHEMICAL BIOLOGY, 页码：1666-1676 , 文章类型： Article，,卷期：2012年7-10] PTPRJ is a receptor-type protein tyrosine phosphatase whose expression is strongly reduced in the majority of investigated cancer cell lines and tumor specimens. PTPRJ negatively interferes with mitogenic signals origina...