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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共17条记录   The Ubiquity of Iron [作者：FREY PERRY A; REED GEORGE H,期刊：ACS CHEMICAL BIOLOGY, 页码：1477-1481 , 文章类型： Article，,卷期：2012年7-9] The importance of iron in living systems can be traced to the many complexes within which it is found, to its chemical mobility in undergoing oxidation-reduction reactions, and to the abundance of iron in Earth's crust. ... Quantitative Synthesis of Genetically Encoded Glycopeptide Libraries Displayed on M13 Phage [作者：NG SIMON; JAFARI MOHAMMAD R; MATOCHKO WADIM L; DERDA RATMIR,期刊：ACS CHEMICAL BIOLOGY, 页码：1482-1487 , 文章类型： Article，,卷期：2012年7-9] Phage display is a powerful technology that enables the discovery of peptide ligands for many targets. Chemical modification of phage libraries have allowed the identification of ligands with properties not encountered i... Discovery of gamma-Secretase Modulators with a Novel Activity Profile by Text-Based Virtual Screening [作者：ZETTL HEIKO; NESS JULIA; HAEHNKE VOLKER; BEHER DIRK; JUMPERTZ THORSTEN; SARIC ARMAN; BAUMANN KARLHEINZ; PIETRZIK CLAUS U; BULIC BRUNO; SCHNEIDER GISBERT; WEGGEN SASCHA,期刊：ACS CHEMICAL BIOLOGY, 页码：1488-1495 , 文章类型： Article，,卷期：2012年7-9] We present an integrated approach to identify and optimize a novel class of gamma-secretase modulators (GSMs) with a unique pharmacological profile. Our strategy included (i) virtual screening through application of a re... Identification of Small-Molecule Antagonists of the Pseudomonas aeruginosa Transcriptional Regulator PqsR: Biophysically Guided Hit Discovery and Optimization [作者：KLEIN TOBIAS; HENN CLAUDIA; DE JONG JOHANNES C; ZIMMER CHRISTINA; KIRSCH BENJAMIN; MAURER CHRISTINE K; PISTORIUS DOMINIK; MUELLER ROLF; STEINBACH ANKE; HARTMANN ROLF W,期刊：ACS CHEMICAL BIOLOGY, 页码：1496-1501 , 文章类型： Article，,卷期：2012年7-9] The Gram-negative pathogen Pseudomonas aeruginosa produces an intercellular alkyl quinolone signaling molecule, the Pseudomonas quinolone signal. The pqs quorum sensing communication system that is characteristic for P. ... The Natural Product Cucurbitacin E Inhibits Depolymerization of Actin Filaments [作者：SOERENSEN PIA M; IACOB ROXANA E; FRITZSCHE MARCO; ENGEN JOHN R; BRIEHER WILLIAM M; CHARRAS GUILLAUME; EGGERT ULRIKE S,期刊：ACS CHEMICAL BIOLOGY, 页码：1502-1508 , 文章类型： Article，,卷期：2012年7-9] Although small molecule actin modulators have been widely used as research tools, only one cell-permeable small molecule inhibitor of actin depolymerization (jasplakinolide) is commercially available. We report that the ... Sialidase Specificity Determined by Chemoselective Modification of Complex Sialylated Glycans [作者：PARKER RANDY B; MCCOMBS JANET E; KOHLER JENNIFER J,期刊：ACS CHEMICAL BIOLOGY, 页码：1509-1514 , 文章类型： Article，,卷期：2012年7-9] Sialidases hydrolytically remove sialic acids from sialylated glycoproteins and glycolipids. Sialidases are widely distributed in nature and sialidase-mediated desialylation is implicated in normal and pathological proce... Identification of a Selective ROR gamma Ligand That Suppresses T(H)17 Cells and Stimulates T Regulatory Cells [作者：SOLT LAURA A; KUMAR NARESH; HE YUANJUN; KAMENECKA THEODORE M; GRIFFIN PATRICK R; BURRIS THOMAS P,期刊：ACS CHEMICAL BIOLOGY, 页码：1515-1519 , 文章类型： Article，,卷期：2012年7-9] Nuclear receptors (NRs) are ligand-regulated transcription factors, many of which are validated targets for clinical purposes. The retinoic acid receptor-related orphan nuclear receptors alpha and gamma t (ROR alpha and ... Inhibiting GPI Anchor Biosynthesis in Fungi Stresses the Endoplasmic Reticulum and Enhances Immunogenicity [作者：MCLELLAN CATHERINE A; WHITESELL LUKE; KING OLIVER D; LANCASTER ALEX K; MAZITSCHEK RALPH; LINDQUIST SUSAN,期刊：ACS CHEMICAL BIOLOGY, 页码：1520-1528 , 文章类型： Article，,卷期：2012年7-9] In fungi, the anchoring of proteins to the plasma membrane via their covalent attachment to glycosylphosphatidylinositol (GPI) is essential and thus provides a valuable point of attack for the development of antifungal t... Biosynthesis of the Class III Lantipeptide Catenulipeptin [作者：WANG HUAN; VAN DER DONK WILFRED A,期刊：ACS CHEMICAL BIOLOGY, 页码：1529-1535 , 文章类型： Article，,卷期：2012年7-9] Lantipeptides are ribosomally synthesized and posttranslationally modified peptides containing lanthionine and/or labionin structures. In this study, a novel class III lantipeptide termed catenulipeptin was discovered fr... Extreme Entropy-Enthalpy Compensation in a Drug-Resistant Variant of HIV-1 Protease [作者：KING NANCY M; PRABUJEYABALAN MOSES; BANDARANAYAKE RAJINTHA M; NALAM MADHAVI N L; NALIVAIKA ELLEN A; OEZEN AYSEGUL; HALILOGLU TURKAN; YILMAZ NESE KURT; SCHIFFER CELIA A,期刊：ACS CHEMICAL BIOLOGY, 页码：1536-1546 , 文章类型： Article，,卷期：2012年7-9] The development of HIV-1 protease inhibitors has been the historic paradigm of rational structure-based drug design, where structural and thermodynamic analyses have assisted in the discovery of novel inhibitors. While t... A Forward Chemical Screen Identifies Antibiotic Adjuvants in Escherichia coli [作者：TAYLOR PATRICIA L; ROSSI LAURA; DE PASCALE GIANFRANCO; WRIGHT GERARD D,期刊：ACS CHEMICAL BIOLOGY, 页码：1547-1555 , 文章类型： Article，,卷期：2012年7-9] Multi-drug-resistant infections caused by Gram-negative pathogens are rapidly increasing, highlighting the need for new chemotherapies. Unlike Gram-positive bacteria, where many different chemical classes of antibiotics ... Pharmacological Tuning of Heat Shock Protein 70 Modulates Polyglutamine Toxicity and Aggregation [作者：CHAFEKAR SIDHARTHA M; WISEN SUSANNE; THOMPSON ANDREA D; ECHEVERRIA ANALISA; WALTER GLADIS M; EVANS CHRISTOPHER G; MAKLEY LEAH N; GESTWICKI JASON E; DUENNWALD MARTIN L,期刊：ACS CHEMICAL BIOLOGY, 页码：1556-1564 , 文章类型： Article，,卷期：2012年7-9] Nine neurodegenerative disorders are caused by the abnormal expansion of polyglutamine (polyQ) regions within distinct proteins. Genetic and biochemical evidence has documented that the molecular chaperone, heat shock pr... Biosynthesis of Albomycin delta(2) Provides a Template for Assembling Siderophore and Aminoacyl-tRNA Synthetase Inhibitor Conjugates [作者：ZENG YU; KULKARNI ADITYA; YANG ZHAOYONG; PATIL PREETI B; ZHOU WEI; CHI XIULING; VAN LANEN STEVEN; CHEN SHAWN,期刊：ACS CHEMICAL BIOLOGY, 页码：1565-1575 , 文章类型： Article，,卷期：2012年7-9] "Trojan horse" antibiotic albomycins are peptidyl nucleosides consisting of a highly modified 4'-thiofuranosyl cytosine moiety and a ferrichrome siderophore that are linked by a peptide bond via a serine residue. While t... Temporal and Fluoride Control of Secondary Metabolism Regulates Cellular Organofluorine Biosynthesis [作者：WALKER MARK C; WEN MIAO; WEEKS AMY M; CHANG MICHELLE C Y,期刊：ACS CHEMICAL BIOLOGY, 页码：1576-1585 , 文章类型： Article，,卷期：2012年7-9] Elucidating mechanisms of natural organofluorine biosynthesis is essential for a basic understanding of fluorine biochemistry in living systems as well as for expanding biological methods for fluorine incorporation into ... Tiny Molecular Beacons: LNA/2 '-O-methyl RNA Chimeric Probes for Imaging Dynamic mRNA Processes in Living Cells [作者：CATRINA IRINA E; MARRAS SALVATORE A E; BRATU DIANA P,期刊：ACS CHEMICAL BIOLOGY, 页码：1586-1595 , 文章类型： Article，,卷期：2012年7-9] New approaches for imaging dynamic processes involving RNAs in living cells are continuously being developed and optimized. The use of molecular beacons synthesized from 2'-O-methylribonucleotides (which are resistant to... Revisiting the Role of Glycosylation in the Structure of Human IgG Fc [作者：BORROK M JACK; JUNG SANG TAEK; KANG TAE HYUN; MONZINGO ARTHUR F; GEORGIOU GEORGE,期刊：ACS CHEMICAL BIOLOGY, 页码：1596-1602 , 文章类型： Article，,卷期：2012年7-9] Binding of the Fc domain of Immunoglobulin G (IgG) to Fc gamma receptors on leukocytes can initiate a series of signaling events resulting in antibody-dependent cell-mediated cytotoxicity (ADCC) and other important immun...