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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共21条记录   Probing the Ca2+ Switch of the Neuronal Ca2+ Sensor GCAP2 by Time-Resolved Fluorescence Spectroscopy [作者：KOLLMANN HEIKO; BECKER SIMON F; SHIRDEL JAVID; SCHOLTEN ALEXANDER; OSTENDORP ANNA; LIENAU CHRISTOPH; KOCH KARLWILHELM,期刊：ACS CHEMICAL BIOLOGY, 页码：1006-1014 , 文章类型： Article，,卷期：2012年7-6] We report fluorescence lifetime and rotational anisotropy measurements of the fluorescent dye Alexa647 attached to the guanylate cyclase-activating protein 2 (GCAP2), an intracellular myristoylated calcium sensor protein... Ligation of Expressed Protein alpha-Hydrazides via Genetic Incorporation of an alpha-Hydroxy Acid [作者：LI YIMING; YANG MAIYUN; HUANG YICHAO; LI YITONG; CHEN PENG R; LIU LEI,期刊：ACS CHEMICAL BIOLOGY, 页码：1015-1022 , 文章类型： Article，,卷期：2012年7-6] Expressed protein ligation bridges the gap between synthetic peptides and recombinant proteins and thereby significantly increases the size and complexity of chemically synthesized proteins. Although the intein-based exp... Altering the Communication Networks of Multispecies Microbial Systems Using a Diverse Toolbox of AI-2 Analogues [作者：GAMBY SONJA; ROY VARNIKA; GUO MIN; SMITH JACQUELINE A I; WANG JINGXIN; STEWART JESSICA E; WANG XIAO; BENTLEY WILLIAM E; SINTIM HERMAN O,期刊：ACS CHEMICAL BIOLOGY, 页码：1023-1030 , 文章类型： Article，,卷期：2012年7-6] There have been intensive efforts to find small molecule antagonists for bacterial quorum sensing (QS) mediated by the "universal" QS autoinducer, AI-2. Previous work has shown that linear and branched aryl analogues of ... Deciphering Structural Elements of Mucin Glycoprotein Recognition [作者：BORGERT ANDREW; HEIMBURGMOLINARO JAMIE; SONG XUEZHENG; LASANAJAK YI; JU TONGZHONG; LIU MIAN; THOMPSON PAMELA; RAGUPATHI GOVIND; BARANY GEORGE; SMITH DAVID F; CUMMINGS RICHARD D; LIVE DAVID,期刊：ACS CHEMICAL BIOLOGY, 页码：1031-1039 , 文章类型： Article，,卷期：2012年7-6] Mucin glycoproteins present a complex structural landscape arising from the multiplicity of glycosylation patterns afforded by their numerous serine and threonine glycosylation sites, often in clusters, and with variatio... Selective Identification of Hedgehog Pathway Antagonists By Direct Analysis of Smoothened Ciliary Translocation [作者：WANG YU; ARVANITES ANTHONY C; DAVIDOW LANCE; BLANCHARD JOEL; LAM KELVIN; YOO JIN WOO; COY SHANNON; RUBIN LEE L; MCMAHON ANDREW P,期刊：ACS CHEMICAL BIOLOGY, 页码：1040-1048 , 文章类型： Article，,卷期：2012年7-6] Hedgehog (Hh) signaling promotes tumorigenesis. The accumulation of the membrane protein Smoothened (Smo) within the primary cilium (PC) is a key event in Hh signal transduction, and many pharmacological inhibitors ident... Butenolide Inhibits Marine Fouling by Altering the Primary Metabolism of Three Target Organisms [作者：ZHANG YIFAN; ZHANG HUOMING; HE LISHENG; LIU CHANGDONG; XU YING; QIAN PEIYUAN,期刊：ACS CHEMICAL BIOLOGY, 页码：1049-1058 , 文章类型： Article，,卷期：2012年7-6] Butenolide is a very promising antifouling compound that inhibits ship hull fouling by a variety of marine organisms, but its antifouling mechanism was previously unknown. Here we report the first study of butenolide's m... Tyrosine Cross-Linking Reveals Interfacial Dynamics in Adeno-Associated Viral Capsids during Infection [作者：HOROWITZ ERIC D; FINN M G; ASOKAN ARAVIND,期刊：ACS CHEMICAL BIOLOGY, 页码：1059-1066 , 文章类型： Article，,卷期：2012年7-6] Viral capsid dynamics are often observed during infectious events such as cell surface attachment, entry and genome release. Structural analysis of adeno-associated virus (AAV), a helper-dependent parvovirus, revealed a ... Targeting Native Adult Heart Progenitors with Cardiogenic Small Molecules [作者：RUSSELL JAMIE L; GOETSCH SEAN C; AGUILAR HECTOR R; FRANTZ DOUG E; SCHNEIDER JAY W,期刊：ACS CHEMICAL BIOLOGY, 页码：1067-1076 , 文章类型： Article，,卷期：2012年7-6] Targeting native progenitors with small molecule pharmaceuticals that direct cell fate decisions is an attractive approach (3, for regenerative medicine. Here, we show that 3,5-disubstituted isoxazoles (Isx), stem cell-m... Regulated Expression of pH Sensing G Protein-Coupled Receptor-68 Identified through Chemical Biology Defines a New Drug Target for Ischemic Heart Disease [作者：RUSSELL JAMIE L; GOETSCH SEAN C; AGUILAR HECTOR R; COE HELEN; LUO XIANG; LIU NING; VAN ROOIJ EVA; FRANTZ DOUG E; SCHNEIDER JAY W,期刊：ACS CHEMICAL BIOLOGY, 页码：1077-1083 , 文章类型： Article，,卷期：2012年7-6] Chemical biology promises discovery of new and unexpected mechanistic pathways, protein functions and disease targets. Here, we probed the mechanism-of-action and protein targets of 3,5-disubstituted isoxazoles (Isx), ca... A Synthetic Peptide Mimic of lambda-Cro shows Sequence-Specific Binding in Vitro and in Vivo [作者：MAZUMDER ABHISHEK; MAITI ATANU; ROY KOUSHIK; ROY SIDDHARTHA,期刊：ACS CHEMICAL BIOLOGY, 页码：1084-1094 , 文章类型： Article，,卷期：2012年7-6] Development of small synthetic transcription factors is important for future cellular engineering and therapeutics. This article describes the chemical synthesis of alpha-amino-isobutyric acid (Aib) substituted, conforma... A Competitive Nucleotide Binding Inhibitor: In Vitro Characterization of Rab7 GTPase Inhibition [作者：AGOLA JACOB O; HONG LIN; SURVILADZE ZURAB; URSU OLEG; WALLER ANNA; STROUSE J JACOB; SIMPSON DENISE S; SCHROEDER CHAD E; OPREA TUDOR I; GOLDEN JENNIFER E; AUBE JEFFREY; BURANDA TIONE; SKLAR LARRY A; WANDINGERNESS ANGELA,期刊：ACS CHEMICAL BIOLOGY, 页码：1095-1108 , 文章类型： Article，,卷期：2012年7-6] Mapping the functionality of GTPases through small molecule inhibitors represents an underexplored area in large part due to the lack of suitable compounds. Here we report on the small chemical molecule 2-(benzoylcarbamo... Spectroscopic, Molecular Modeling, and NMR-Spectroscopic Investigation of the Binding Mode of the Natural Alkaloids Berberine and Sanguinarine to Human Telomeric G-Quadruplex DNA [作者：BESSI IRENE; BAZZICALUPI CARLA; RICHTER CHRISTIAN; JONKER HENDRIK R A; SAXENA KRISHNA; SISSI CLAUDIA; CHIOCCIOLI MATTEO; BIANCO SARA; BILIA ANNA RITA; SCHWALBE HARALD; GRATTERI PAOLA,期刊：ACS CHEMICAL BIOLOGY, 页码：1109-1119 , 文章类型： Article，,卷期：2012年7-6] G-quadruplex structures can be formed at the single-stranded overhang of telomeric DNA, and ligands able to stabilize this structure have recently been identified as potential anticancer drugs. Among the potential G-quad... Mechanism and Rates of Exchange of L7/L12 between Ribosomes and the Effects of Binding EF-G [作者：DEROO STEPHANIE; HYUNG SUKJOON; MARCOUX JULIEN; GORDIYENKO YULIYA; KORIPELLA RAVI KIRAN; SANYAL SUPARNA; ROBINSON CAROL V,期刊：ACS CHEMICAL BIOLOGY, 页码：1120-1127 , 文章类型： Article，,卷期：2012年7-6] The ribosomal stalk complex binds and recruits translation factors to the ribosome during protein biosynthesis. In Escherichia coli the stalk is composed of protein L10 and four copies of L7/L12. Despite the crucial role... Protein Lysine Acylation and Cysteine Succination by Intermediates of Energy Metabolism [作者：LIN HENING; SU XIAOYANG; HE BIN,期刊：ACS CHEMICAL BIOLOGY, 页码：947-960 , 文章类型： Review，,卷期：2012年7-6] In the past few years., several new protein post-translational modifications that use intermediates in metabolism have been discovered. These include various acyl lysine modifications (formylation, propionylation, butyry... A Novel Ascaroside Controls the Parasitic Life Cycle of the Entomopathogenic Nematode Heterorhabditis bacteriophora [作者：NOGUEZ JAIME H; CONNER ELIZABETH S; ZHOU YUE; CICHE TODD A; RAGAINS JUSTIN R; BUTCHER REBECCA A,期刊：ACS CHEMICAL BIOLOGY, 页码：961-966 , 文章类型： Article，,卷期：2012年7-6] Entomopathogenic nematodes survive in the soil as stress-resistant infective juveniles that seek out and infect insect hosts. Upon sensing internal host cues, the infective juveniles regurgitate bacterial pathogens from ... Genetically Encoded Photo-cross-linkers Map the Binding Site of an Allosteric Drug on a G Protein-Coupled Receptor [作者：GRUNBECK AMY; HUBER THOMAS; ABROL RAVINDER; TRZASKOWSKI BARTOSZ; GODDARD WILLIAM A III; SAKMAR THOMAS P,期刊：ACS CHEMICAL BIOLOGY, 页码：967-972 , 文章类型： Article，,卷期：2012年7-6] G protein-coupled receptors (GPCRs) are dynamic membrane proteins that bind extracellular molecules to transduce signals. Although GPCRs represent the largest class of therapeutic targets, only a small percentage of thei...