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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共21条记录   Functional Detection of Proteins by Caged Aptamers [作者：PINTO ALESSANDRO; LENNARZ SABINE; RODRIGUESCORREIA ALEXANDRE; HECKEL ALEXANDER; OSULLIVAN CIARA K; MAYER GUENTER,期刊：ACS CHEMICAL BIOLOGY, 页码：359-365 , 文章类型： Article，,卷期：2012年7-2] While many diagnostic assay platforms enable the measurement of analytes with high sensitivity, most of them result in a disruption of the analyte's native structure and, thus, in loss of function. Consequently, the anal... Inhibition of Hematopoietic Protein Tyrosine Phosphatase Augments and Prolongs ERK1/2 and p38 Activation [作者：SERGIENKO EDUARD; XU JIAN; LIU WALLACE H; DAHL RUSSELL; CRITTON DAVID A; SU YING; BROWN BROCK T; CHAN XOCHELLA; YANG LI; BOBKOVA EKATERINA V; VASILE STEFAN; YUAN HONGBIN; RASCON JUSTIN; COLAYCO SHARON; SIDIQUE SHYAMA; COSFORD NICHOLAS D P; CHUNG THOMAS D Y; MUSTELIN TOMAS; PAGE REBECCA; LOMBROSO PAUL J; TAUTZ LUTZ,期刊：ACS CHEMICAL BIOLOGY, 页码：366-376 , 文章类型： Article，,卷期：2012年7-2] The hematopoietic protein tyrosine phosphatase (HePTP) is implicated in the development of blood cancers through its ability to negatively regulate the mitogen-activated protein kinases (MAPKs) ERK1/2 and p38. Small-mole... Characterization of Molecular Interactions between ACP and Halogenase Domains in the Curacin A Polyketide Synthase [作者：BUSCHE ALENA; GOTTSTEIN DANIEL; HEIN CHRISTOPHER; RIPIN NINA; PADER IRINA; TUFAR PETER; EISMAN ELI B; GU LIANGCAI; WALSH CHRISTOPHER T; SHERMAN DAVID H; LOEHR FRANK; GUENTERT PETER; DOETSCH VOLKER,期刊：ACS CHEMICAL BIOLOGY, 页码：377-385 , 文章类型： Article，,卷期：2012年7-2] Polyketide synthases (PKSs) and non-ribosomal peptide synthetases (NRPSs) are large multidomain proteins present in microorganisms that produce bioactive compounds. Curacin A is such a bioactive compound with potent anti... Effects of Ethanol on Conformational Changes of Akt Studied by Chemical Cross-Linking, Mass Spectrometry, and O-18 Labeling [作者：HUANG BILL X; KIM HEEYONG,期刊：ACS CHEMICAL BIOLOGY, 页码：386-393 , 文章类型： Article，,卷期：2012年7-2] Although PI3K/Akt signaling that regulates neuronal survival has been implicated in the deleterious effects of ethanol on the central nervous system, underlying molecular mechanisms have not been fully elucidated. Akt-me... Agouti-Related Protein Segments Outside of the Receptor Binding Core Are Required for Enhanced Short- and Long-term Feeding Stimulation [作者：MADONNA MICHAEL E; SCHURDAK JENNIFER; YANG YINGKUI; BENOIT STEPHEN; MILLHAUSER GLENN L,期刊：ACS CHEMICAL BIOLOGY, 页码：394-401 , 文章类型： Article，,卷期：2012年7-2] The agouti-related protein (AgRP) plays a central role in energy balance by reducing signaling through the hypothalamic melanocortin receptors (McRs) 3 and 4, in turn stimulating feeding and decreasing energy expenditure... Small Molecule Inhibition of RISC Loading [作者：TAN GRACE S; CHIU CHUNHAO; GARCHOW BARRY G; METZLER DAVID; DIAMOND SCOTT L; KIRIAKIDOU MARIANTHI,期刊：ACS CHEMICAL BIOLOGY, 页码：402-409 , 文章类型： Article，,卷期：2012年7-2] Argonaute proteins are the core components of the microRNP/RISC. The biogenesis and function of microRNAs and endo- and exo- siRNAs are regulated by Ago2, an Argonaute protein with RNA binding and nuclease activities. Cu... Chemical Form Matters: Differential Accumulation of Mercury Following Inorganic and Organic Mercury Exposures in Zebrafish Larvae [作者：KORBAS MALGORZATA; MACDONALD TRACY C; PICKERING INGRID J; GEORGE GRAHAM N; KRONE PATRICK H,期刊：ACS CHEMICAL BIOLOGY, 页码：410-419 , 文章类型： Article，,卷期：2012年7-2] Mercury, one of the most toxic elements, exists in various chemical forms each with different toxicities and health implications. Some methylated mercury forms, one of which exists in fish and other seafood products, pos... Chemistry and Biology of the Copper Chelator Methanobactin [作者：KENNEY GRACE E; ROSENZWEIG AMY C,期刊：ACS CHEMICAL BIOLOGY, 页码：A-I , 文章类型： Review，,卷期：2012年7-2] Methanotrophic bacteria, organisms that oxidize. methane, produce a small copper chelating molecule called methanobactin (Mb). Mb binds Cu(I) with high affinity and is hypothesized to mediate copper acquisition from the ... Har Gobind Khorana (1922-2011): Chemical Biology Pioneer [作者：SAKMAR THOMAS P,期刊：ACS CHEMICAL BIOLOGY, 页码：250-251 , 文章类型： Editorial Material，,卷期：2012年7-2] Introducing the Parvome: Bioactive Compounds in the Microbial World [作者：DAVIES JULIAN; RYAN KATHERINE S,期刊：ACS CHEMICAL BIOLOGY, 页码：252-259 , 文章类型： Review，,卷期：2012年7-2] We describe and discuss the features and functions of the "parvome", the "-ome" of the chemical world, consisting of the small molecules produced by living organisms. Here, we focus specifically on the world of microbial... Targeting the Assembly of Bacterial Cell Division Protein FtsZ with Small Molecules [作者：SCHAFFNERBARBERO CLAUDIA; MARTINFONTECHA MAR; CHACON PABLO; ANDREU JOSE M,期刊：ACS CHEMICAL BIOLOGY, 页码：268-276 , 文章类型： Review，,卷期：2012年7-2] FtsZ is the key protein of bacterial cell division and an emergent target for new antibiotics. It is a filament-forming GTPase and a structural homologue of eukaryotic tubulin. A number of FtsZ-interacting compounds have... Winning the Arms Race by Improving Drug Discovery against Mutating Targets [作者：ANDERSON AMY C,期刊：ACS CHEMICAL BIOLOGY, 页码：277-287 , 文章类型： Review，,卷期：2012年7-2] Enzymes are often excellent drug targets. Yet drug pressure on an enzyme target often fosters the rise of cells with resistance-conferring mutations, some of which may compromise fitness and others that compensate to res... A Caged, Localizable Rhodamine Derivative for Superresolution Microscopy [作者：BANALA SAMBASHIVA; MAUREL DAMIEN; MANLEY SULIANA; JOHNSSON KAI,期刊：ACS CHEMICAL BIOLOGY, 页码：288-292 , 文章类型： Article，,卷期：2012年7-2] A caged rhodamine 110 derivative for the specific labeling of SNAP-tag fusion proteins is introduced. The caged rhodamine 110 derivative permits the labeling of cell surface proteins in living cells and of intracellular ... Thermodynamic Evidence for Negative Charge Stabilization by a Catalytic Metal Ion within an RNA Active Site [作者：SENGUPTA RAGHUVIR N; HERSCHLAG DANIEL; PICCIRILLI JOSEPH A,期刊：ACS CHEMICAL BIOLOGY, 页码：293-298 , 文章类型： Article，,卷期：2012年7-2] Protein and RNA enzymes that catalyze phosphoryl transfer reactions frequently contain active site metal ions that interact with the nucleophile and leaving group. Mechanistic models generally hinge upon the assumption t... Diversity of Archaeosine Synthesis in Crenarchaeota [作者：PHILLIPS GABRIELA; SWAIRJO MANAL A; GASTON KIRK W; BAILLY MARC; LIMBACH PATRICK A; IWATAREUYL DIRK; DE CRECYLAGARD VALERIE,期刊：ACS CHEMICAL BIOLOGY, 页码：299-304 , 文章类型： Article，,卷期：2012年7-2] Archaeosine (G(+)) is found at position 15 of many archaeal tRNAs. In Euryarchaeota, the G(+) precursor, 7-cyano-7-deazaguanine (preQ(0)), is inserted into tRNA by tRNA-guanine transglycosylase (arcTGT) before conversion... Iron-Sulfur Cluster Engineering Provides Insight into the Evolution of Substrate Specificity among Sulfonucleotide Reductases [作者：BHAVE DEVAYANI P; HONG JIYOUNG A; KELLER REBECCA L; KREBS CARSTEN; CARROLL KATE S,期刊：ACS CHEMICAL BIOLOGY, 页码：305-314 , 文章类型： Article，,卷期：2012年7-2] Assimilatory sulfate reduction supplies prototrophic organisms with reduced sulfur that is required for the biosynthesis of all sulfur-containing metabolites, including cysteine and methionine. The reduction of sulfate r...