- The Arp2/3 activator WASH regulates alpha 5 beta 1-integrin-mediated invasive migration
[作者:Zech, T; Calaminus, SDJ; Caswell, P; Spence, HJ; Carnell, M; Insall, RH; Norman, J; Machesky, LM,期刊:Journal of cell science, 页码:3753-3759 , 文章类型: Article,,卷期:2011年124-22]
- The actin cytoskeleton provides scaffolding and physical force to effect fundamental processes such as motility, cytokinesis and vesicle trafficking. The Arp2/3 complex nucleates actin structures and contributes to endoc...
- MLCK regulates Schwann cell cytoskeletal organization, differentiation and myelination
[作者:Leitman, EM; Tewari, A; Horn, M; Urbanski, M; Damanakis, E; Einheber, S; Salzer, JL; de Lanerolle, P; Melendez-Vasquez, CV,期刊:Journal of cell science, 页码:3784-3796 , 文章类型: Article,,卷期:2011年124-22]
- Signaling through cyclic AMP (cAMP) has been implicated in the regulation of Schwann cell (SC) proliferation and differentiation. In quiescent SCs, elevation of cAMP promotes the expression of proteins associated with my...
- Rac deletion in osteoclasts causes severe osteopetrosis
[作者:Croke, M; Ross, FP; Korhonen, M; Williams, DA; Zou, W; Teitelbaum, SL,期刊:Journal of cell science, 页码:3811-3821 , 文章类型: Article,,卷期:2011年124-22]
- Cdc42 mediates bone resorption principally by stimulating osteoclastogenesis. Whether its sister GTPase, Rac, meaningfully impacts upon the osteoclast and, if so, by what means, is unclear. We find that whereas deletion ...
- A coiled-coil- and C2-domain-containing protein is required for FAZ assembly and cell morphology in Trypanosoma brucei
[作者:Zhou, Q; Liu, BH; Sun, Y; He, CY,期刊:Journal of cell science, 页码:3848-3858 , 文章类型: Article,,卷期:2011年124-22]
- Trypanosoma brucei, a flagellated protozoan parasite causing human sleeping sickness, relies on a subpellicular microtubule array for maintenance of cell morphology. The flagellum is attached to the cell body through a p...
- Dynamics of CENP-N kinetochore binding during the cell cycle
[作者:Hellwig, D; Emmerth, S; Ulbricht, T; Doring, V; Hoischen, C; Martin, R; Samora, CP; McAinsh, AD; Carroll, CW; Straight, AF; Meraldi, P; Diekmann, S,期刊:Journal of cell science, 页码:3871-3883 , 文章类型: Article,,卷期:2011年124-22]
- Accurate chromosome segregation requires the assembly of kinetochores, multiprotein complexes that assemble on the centromere of each sister chromatid. A key step in this process involves binding of the constitutive cent...
- Spindle positioning in human cells relies on proper centriole formation and on the microcephaly proteins CPAP and STIL
[作者:Kitagawa, D; Kohlmaier, G; Keller, D; Strnad, P; Balestra, FR; Fluckiger, I; Gonczy, P,期刊:Journal of cell science, 页码:3884-3893 , 文章类型: Article,,卷期:2011年124-22]
- Patients with MCPH (autosomal recessive primary microcephaly) exhibit impaired brain development, presumably due to the compromised function of neuronal progenitors. Seven MCPH loci have been identified, including one th...
- A role for seipin in lipid droplet dynamics and inheritance in yeast
[作者:Wolinski, H; Kolb, D; Hermann, S; Koning, RI; Kohlwein, SD,期刊:Journal of cell science, 页码:3894-3904 , 文章类型: Article,,卷期:2011年124-22]
- Malfunctions of processes involved in cellular lipid storage and mobilization induce the pathogenesis of prevalent human diseases such as obesity, type 2 diabetes and atherosclerosis. Lipid droplets are the main lipid st...
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