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  • Rac deletion in osteoclasts causes severe osteopetrosis
    [作者:Croke, M; Ross, FP; Korhonen, M; Williams, DA; Zou, W; Teitelbaum, SL,期刊:Journal of cell science, 页码:3811-3821 , 文章类型: Article,,卷期:2011年124-22]
  • Cdc42 mediates bone resorption principally by stimulating osteoclastogenesis. Whether its sister GTPase, Rac, meaningfully impacts upon the osteoclast and, if so, by what means, is unclear. We find that whereas deletion ...
  • Dynamics of CENP-N kinetochore binding during the cell cycle
    [作者:Hellwig, D; Emmerth, S; Ulbricht, T; Doring, V; Hoischen, C; Martin, R; Samora, CP; McAinsh, AD; Carroll, CW; Straight, AF; Meraldi, P; Diekmann, S,期刊:Journal of cell science, 页码:3871-3883 , 文章类型: Article,,卷期:2011年124-22]
  • Accurate chromosome segregation requires the assembly of kinetochores, multiprotein complexes that assemble on the centromere of each sister chromatid. A key step in this process involves binding of the constitutive cent...