- MMP9 cleavage of the beta 4 integrin ectodomain leads to recurrent epithelial erosions in mice
[作者:Pal-Ghosh, S; Blanco, T; Tadvalkar, G; Pajoohesh-Ganji, A; Parthasarathy, A; Zieske, JD; Stepp, MA,期刊:Journal of cell science, 页码:2666-2675 , 文章类型: Article,,卷期:2011年124-15]
- Integrin alpha 6 beta 4 is an integral membrane protein within hemidesmosomes and it mediates adhesion of epithelial cells to their underlying basement membrane. During wound healing, disassembly of hemidesmosomes must o...
- Phospholipase C zeta binding to PtdIns(4,5)P-2 requires the XY-linker region
[作者:Nomikos, M; Elgmati, K; Theodoridou, M; Calver, BL; Nounesis, G; Swann, K; Lai, FA,期刊:Journal of cell science, 页码:2582-2590 , 文章类型: Article,,卷期:2011年124-15]
- Phospholipase C-zeta (PLC zeta) is a strong candidate for the mammalian sperm-derived factor that triggers the Ca2+ oscillations required for egg activation at fertilization. PLC zeta lacks a PH domain, which targets PLC...
- Cumulated Ca2+ spike duration underlies Ca2+ oscillation frequency-regulated NF kappa B transcriptional activity
[作者:Zhu, LP; Song, SS; Pi, YB; Yu, Y; She, WB; Ye, H; Su, Y; Hu, QH,期刊:Journal of cell science, 页码:2591-2601 , 文章类型: Article,,卷期:2011年124-15]
- [Ca2+](i) oscillations drive downstream events, like transcription, in a frequency-dependent manner. Why [Ca2+](i) oscillation frequency regulates transcription has not been clearly revealed. A variation in [Ca2+](i) osc...
- Notch gain of function in mouse periocular mesenchyme downregulates FoxL2 and impairs eyelid levator muscle formation, leading to congenital blepharophimosis
[作者:Zhang, YJ; Kao, WWY; Pelosi, E; Schlessinger, D; Liu, CY,期刊:Journal of cell science, 页码:2561-2572 , 文章类型: Article,,卷期:2011年124-15]
- Notch signaling is pivotal for the morphogenesis and homeostasis of many tissues. We found that aberrant Notch activation in mouse neural-crest-derived periocular mesenchymal cells (POMCs), which contribute to the format...
- Myosin-1C associates with microtubules and stabilizes the mitotic spindle during cell division
[作者:Rump, A; Scholz, T; Thiel, C; Hartmann, FK; Uta, P; Hinrichs, MH; Taft, MH; Tsiavaliaris, G,期刊:Journal of cell science, 页码:2521-2528 , 文章类型: Article,,卷期:2011年124-15]
- The mitotic spindle in eukaryotic cells is composed of a bipolar array of microtubules (MTs) and associated proteins that are required during mitosis for the correct partitioning of the two sets of chromosomes to the dau...
- Protein 4.1R regulates cell migration and IQGAP1 recruitment to the leading edge
[作者:Ruiz-Saenz, A; Kremer, L; Alonso, MA; Millan, J; Correas, I,期刊:Journal of cell science, 页码:2529-2538 , 文章类型: Article,,卷期:2011年124-15]
- In red blood cells, multifunctional protein 4.1R stabilizes the spectrin-actin network and anchors it to the plasma membrane. To contribute to the characterization of functional roles of 4.1R in nonerythroid cells, we ha...
- Fluorescent proteins at a glance (vol 124, pg 157, 2011)
[作者:Kremers, GJ; Gilbert, SG; Cranfill, PJ; Davidson, MW; Piston, DW,期刊:Journal of cell science, 页码:2676-2676 , 文章类型: Correction,,卷期:2011年124-15]
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- EB1 and EB3 promote cilia biogenesis by several centrosome-related mechanisms
[作者:Schroder, JM; Larsen, J; Komarova, Y; Akhmanova, A; Thorsteinsson, RI; Grigoriev, I; Manguso, R; Christensen, ST; Pedersen, SF; Geimer, S; Pedersen, LB,期刊:Journal of cell science, 页码:2539-2551 , 文章类型: Article,,卷期:2011年124-15]
- The microtubule (MT) plus-end-tracking protein EB1 is required for assembly of primary cilia in mouse fibroblasts, but the mechanisms involved and the roles of the related proteins EB2 and EB3 in ciliogenesis are unknown...
- Microtubule remodelling is required for the front-rear polarity switch during contact inhibition of locomotion
[作者:Kadir, S; Astin, JW; Tahtamouni, L; Martin, P; Nobes, CD,期刊:Journal of cell science, 页码:2642-2653 , 文章类型: Article,,卷期:2011年124-15]
- When migrating mesenchymal cells collide, they exhibit a 'contact inhibition of locomotion' response that results in reversal of their front-rear polarity by extension of a new leading edge, which enables their migration...
- A novel role for neural cell adhesion molecule in modulating insulin signaling and adipocyte differentiation of mouse mesenchymal stem cells
[作者:Yang, HJ; Xia, YY; Wang, L; Liu, R; Goh, KJ; Ju, PJ; Feng, ZW,期刊:Journal of cell science, 页码:2552-2560 , 文章类型: Article,,卷期:2011年124-15]
- Neural cell adhesion molecule (NCAM) has recently been found on adult stem cells, but its biological significance remains largely unknown. In this study, we used bone-marrow-derived mesenchymal stem cells (MSCs) from wil...
- Banf1 is required to maintain the self-renewal of both mouse and human embryonic stem cells
[作者:Cox, JL; Mallanna, SK; Ormsbee, BD; Desler, M; Wiebe, MS; Rizzino, A,期刊:Journal of cell science, 页码:2654-2665 , 文章类型: Article,,卷期:2011年124-15]
- Self-renewal is a complex biological process necessary for maintaining the pluripotency of embryonic stem cells (ESCs). Recent studies have used global proteomic techniques to identify proteins that associate with the ma...
- The E3 ubiquitin ligase specificity subunit ASB2 alpha targets filamins for proteasomal degradation by interacting with the filamin actin-binding domain
[作者:Razinia, Z; Baldassarre, M; Bouaouina, M; Lamsoul, I; Lutz, PG; Calderwood, DA,期刊:Journal of cell science, 页码:2631-2641 , 文章类型: Article,,卷期:2011年124-15]
- Filamins are an important family of actin-binding and crosslinking proteins that mediate remodeling of the actin cytoskeleton and maintain extracellular matrix connections by anchoring transmembrane proteins to actin fil...
- The gap junction protein Cx43 regulates B-lymphocyte spreading and adhesion
[作者:Machtaler, S; Dang-Lawson, M; Choi, K; Jang, C; Naus, CC; Matsuuchi, L,期刊:Journal of cell science, 页码:2611-2621 , 文章类型: Article,,卷期:2011年124-15]
- The gap junction protein connexin43 (Cx43) is widely expressed in mammalian cells and forms intercellular channels for the transfer of small molecules between adjacent cells, as well as hemichannels that mediate bidirect...
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