- Peptides in cancer nanomedicine: Drug carriers, targeting ligands and protease substrates
[作者:Zhang, XX; Eden, HS; Chen, XY,期刊:Journal of controlled release, 页码:2-13 , 文章类型: Review,,卷期:2012年159-1]
- Peptides are attracting increasing attention as therapeutic agents, as the technologies for peptide development and manufacture continue to mature. Concurrently, with booming research in nanotechnology for biomedical app...
- Local drug delivery strategies for cancer treatment: Gels, nanoparticles, polymeric films, rods, and wafers
[作者:Wolinsky, JB; Colson, YL; Grinstaff, MW,期刊:Journal of controlled release, 页码:14-26 , 文章类型: Review,,卷期:2012年159-1]
- Polymer-based drug delivery depots have been investigated over the last several decades as a means to improve upon the lack of tumor targeting and severe systemic morbidities associated with intravenous chemotherapy trea...
- Novel nanocomposite stent coating releasing resveratrol and quercetin reduces neointimal hyperplasia and promotes re-endothelialization
[作者:Kleinedler, JJ; Foley, JD; Orchard, EA; Dugas, TR,期刊:Journal of controlled release, 页码:27-33 , 文章类型: Article,,卷期:2012年159-1]
- Late-term thrombosis associated with drug-eluting stents may be due to the non-selective actions of antimitogenic drugs on endothelial cells, leading to delayed vascular healing after stenting angioplasty. Currently, the...
- Coated microneedle arrays for transcutaneous delivery of live virus vaccines
[作者:Vrdoljak, A; McGrath, MG; Carey, JB; Draper, SJ; Hill, AVS; O'Mahony, C; Crean, AM; Moore, AC,期刊:Journal of controlled release, 页码:34-42 , 文章类型: Article,,卷期:2012年159-1]
- Vaccines are sensitive biologics that require continuous refrigerated storage to maintain their viability. The vast majority of vaccines are also administered using needles and syringes. The need for cold chain storage a...
- Facilitation of transcutaneous drug delivery and vaccine immunization by a safe laser technology
[作者:Chen, XY; Shah, D; Kositratna, G; Manstein, D; Anderson, RR; Wu, MX,期刊:Journal of controlled release, 页码:43-51 , 文章类型: Article,,卷期:2012年159-1]
- Full-surface laser ablation has been shown to efficiently disrupt stratum corneum and facilitate transcutaneous drug delivery, but it is frequently associated with skin damage that hampers its clinic use. We show here th...
- Dissolving polymeric microneedle arrays for electrically assisted transdermal drug delivery
[作者:Garland, MJ; Caffarel-Salvador, E; Migalska, K; Woolfson, AD; Donnelly, RF,期刊:Journal of controlled release, 页码:52-59 , 文章类型: Article,,卷期:2012年159-1]
- It has recently been proposed that the combination of skin barrier impairment using microneedles (MNs) coupled with iontophoresis (ITP) may broaden the range of drugs suitable for transdermal delivery, as well as enablin...
- Predictability of drug release from cochlear implants
[作者:Krenzlin, S; Vincent, C; Munzke, L; Gnansia, D; Siepmann, J; Siepmann, F,期刊:Journal of controlled release, 页码:60-68 , 文章类型: Article,,卷期:2012年159-1]
- A simplified mathematical theory is presented allowing for in silico simulation of the effects of key parameters of miniaturized implants (size and composition) on the resulting drug release kinetics. Such devices offer ...
- Non-glycosylated BMP-2 can induce ectopic bone formation at lower concentrations compared to glycosylated BMP-2
[作者:van de Watering, FCJ; van den Beucken, JJJP; van der Woning, SP; Briest, A; Eek, A; Qureshi, H; Winnubst, L; Boerman, OC; Jansen, JA,期刊:Journal of controlled release, 页码:69-77 , 文章类型: Article,,卷期:2012年159-1]
- Bone morphogenic protein-2 (BMP-2) is a well-known growth factor that can improve the biological performance of bone substitute materials. BMP-2 produced via bacterial expression systems are non-glycosylated (ng) whereas...
- Controlled release formulations of IL-2, TGF-beta 1 and rapamycin for the induction of regulatory T cells
[作者:Jhunjhunwala, S; Balmert, SC; Raimondi, G; Dons, E; Nichols, EE; Thomson, AW; Little, SR,期刊:Journal of controlled release, 页码:78-84 , 文章类型: Article,,卷期:2012年159-1]
- The absence of regulatory T cells (Treg) is a hallmark for a wide variety of disorders such as autoimmunity, dermatitis, periodontitis and even transplant rejection. A potential treatment option for these disorders is to...
- Implantable pneumatically actuated microsystem for renal pressure-mediated transfection in mice
[作者:Shimizu, K; Kawakami, S; Hayashi, K; Mori, Y; Hashida, M; Konishi, S,期刊:Journal of controlled release, 页码:85-91 , 文章类型: Article,,卷期:2012年159-1]
- In vivo transfection is an important technique used in biological research and drug therapy development. Previously, we developed a renal pressure-mediated transfection method performed by pressing a kidney after an intr...
- Controlled shielding and deshielding of gene delivery polyplexes using hydroxyethyl starch (HES) and alpha-amylase
[作者:Noga, M; Edinger, D; Rodl, W; Wagner, E; Winter, G; Besheer, A,期刊:Journal of controlled release, 页码:92-103 , 文章类型: Article,,卷期:2012年159-1]
- The non-viral delivery of nucleic acids faces many extracellular and intracellular hurdles on the way from injection site to the site of action. Among these, aggregation in the blood stream and rapid elimination by the m...
- Transfecting the hard-to-transfect lymphoma/leukemia cells using a simple cationic polymer nanocomplex
[作者:Zhao, NX; Qi, JJ; Zeng, ZH; Parekh, P; Chang, CC; Tung, CH; Zu, YL,期刊:Journal of controlled release, 页码:104-110 , 文章类型: Article,,卷期:2012年159-1]
- Although the development of gene delivery systems via non-viral-mediated methods is advancing rapidly, it remains a challenge to deliver plasmids into hard-to-transfect cells, such as lymphoma/leukemia cells. To develop ...
- NIR-light triggered delivery of macromolecules into the cytosol
[作者:Carregal-Romero, S; Ochs, M; Rivera-Gil, P; Ganas, C; Pavlov, AM; Sukhorukov, GB; Parak, WJ,期刊:Journal of controlled release, 页码:120-127 , 文章类型: Article,,卷期:2012年159-1]
- Light-responsive microcapsules constructed by layer-by-layer self-assembly are used as microcarriers to deliver different macromolecules inside cells. The microcapsules carry the macromolecules as cargo in their cavity, ...
- Mucociliary clearance of micro- and nanoparticles is independent of size, shape and charge-an ex vivo and in silico approach
[作者:Kirch, J; Guenther, M; Doshi, N; Schaefer, UF; Schneider, M; Mitragotri, S; Lehr, CM,期刊:Journal of controlled release, 页码:128-134 , 文章类型: Article,,卷期:2012年159-1]
- The fate of inhaled particles after deposition onto the pulmonary mucosa is far from being solved, in particular with respect to mucociliary clearance and mucus penetration. Due to the fact that these phenomena govern pu...
- PEGylated cationic liposomes robustly augment vaccine-induced immune responses: Role of lymphatic trafficking and biodistribution
[作者:Zhuang, Y; Ma, YF; Wang, C; Hai, L; Yan, C; Zhang, YJ; Liu, FZ; Cai, LT,期刊:Journal of controlled release, 页码:135-142 , 文章类型: Article,,卷期:2012年159-1]
- Lymph nodes (LNs) are peripheral lymphoid organs essential for vaccine-induced immune responses. Although cationic liposomes have been documented as a novel adjuvant and vaccine delivery system, whether enhancing LN targ...
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