- Studies on novel 4 beta-[(4-substituted)-1,2,3-triazol-1-yl] podophyllotoxins as potential anticancer agents
[作者:Bhat, BA; Reddy, PB; Agrawal, SK; Saxena, AK; Kumar, HMS; Qazi, GN,期刊:European Journal of Medicinal Chemistry, 页码:2067-2072 , 文章类型: Article,,卷期:2008年43-10]
A series of 4 beta-[(4-substituted)-1,2,3-triazol-1-yl] podophyllotoxin congeners have been designed and synthesized with significant regioselectivity by employing Cu(I) catalyzed 1,3-dipolar cycloaddition reaction of...
- Condensed bridgehead nitrogen heterocyclic system: Synthesis and pharmacological activities of 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole derivatives of ibuprofen and biphenyl-4-yloxy acetic acid
[作者:Amir, M; Kumar, H; Javed, SA,期刊:European Journal of Medicinal Chemistry, 页码:2056-2066 , 文章类型: Article,,卷期:2008年43-10]
Several 3,6-disubstituted-1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazoles were prepared by condensation of 4-amino-5-substituted-3-mercapto-(4H)-1,2,4-triazoles (3a,b) with various substituted aromatic acids and aryl/alkyl ...
- Synthesis and biological evaluation of amide derivatives of (5,6-dimethoxy-2,3-dihydro-1H-inden-1-yl)acetic acid as anti-inflammatory agents with reduced gastrointestinal ulcerogenecity
[作者:Sharma, M; Ray, SM,期刊:European Journal of Medicinal Chemistry, 页码:2092-2102 , 文章类型: Article,,卷期:2008年43-10]
A variety of amide derivatives of (5,6-dimethoxy-2,3-dihydro-1H-inden-1-yl)acetic acid were synthesized and screened for their analgesic and anti-inflammatory activities. The compounds were found to have longer activi...
- DNA binding and biological studies of some novel water-soluble polymer-copper(II)-phenanthroline complexes
[作者:Kumar, RS; Arunachalam, S; Periasamy, VS; Preethy, CP; Riyasdeen, A; Akbarsha, MA,期刊:European Journal of Medicinal Chemistry, 页码:2082-2091 , 文章类型: Article,,卷期:2008年43-10]
Some novel water-soluble polymer-copper(II)-phenanthroline complex samples, [Cu(phen)(2)(BPEI)]Cl-2 center dot 4H(2)O (phen = 1,10-phenanthroline, BPEI = branched polyethyleneimine), with different degrees of copper c...
- Synthesis and antimicrobial activity of some new heterocycles incorporating antipyrine moiety
[作者:Bondock, S; Rabie, R; Etman, HA; Fadda, AA,期刊:European Journal of Medicinal Chemistry, 页码:2122-2129 , 文章类型: Article,,卷期:2008年43-10]
2-Cyano-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)acetamide (1) was utilized as key intermediate for the synthesis of some new coumarin 2, pyridine 3, pyrrole 4, thiazole 7, pyrido[2',3':3,4][pyrazolo...
- The antioxidant activity of 2-(4(or 2)-hydroxyl-5-chloride-1,3-benzene-di-sulfanimide)-chitosan
[作者:Zhong, ZM; Xing, R; Liu, S; Wang, L; Cai, SB; Li, PC,期刊:European Journal of Medicinal Chemistry, 页码:2171-2177 , 文章类型: Article,,卷期:2008年43-10]
Chitosan (CS) with two different molecular weights was modified by reacting with 4-hydroxyl-5-chloride-1,3-benzene-disulfo-chloride or 2-hydroxyl-5-chloride-1,3-benzene-disulfo-chloride to give new 2-(4(or 2)-hydroxyl...
- Synthesis, characterization and antibacterial activity of cobalt(III) complexes with pyridine-amide ligands
[作者:Mishra, A; Kaushik, NK; Verma, AK; Gupta, R,期刊:European Journal of Medicinal Chemistry, 页码:2189-2196 , 文章类型: Article,,卷期:2008年43-10]
The ligands 2-(N-(X-pyridyl)carbamoyl)pyridine (X = 2, 3 or 4 for HL1-HL3, respectively) and 2,6-bis(N-(Y-pyridyl)carbamoyl)pyridine (Y = 2, 3 or 4 for H2L4-H2L6, respectively) in their mono- and di-deprotonated forms...
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